3. Getting an Inside Look: Given Imaging’s Camera Pilla
Gavriel Iddan was an electro-optical engineer at Israel’s Rafael Armament Development
Authority, the Israeli authority for development of weapons and military technology. One of Iddan’s
projects was to develop the “eye” of a guided missile, which leads the missile to its target. In 1981,
Iddan traveled to Boston on sabbatical to work for a company that produced X-ray tubes and
ultrasonic probes. While there, he befriended a gastroenterologist (a physician who focuses on
digestive diseases) named Eitan Scapa. During long conversations in which each would discuss his
respective field, Scapa taught Iddan about the technologies used to view the interior lining of the
digestive system. Scapa pointed out that the existing technologies had a number of significant
limitations, particularly with respect to viewing the small intestine.b The small intestine is the locale
of a number of serious disorders. In the United States alone, approximately 19 million people suffer
from disorders in the small intestine (including bleeding, Crohn’s disease, celiac disease, chronic
diarrhea, irritable bowel syndrome, and small bowel cancer)
4. • Furthermore, the nature of the small intestine makes it a difficult place to diagnose
and treat such disorders. The small intestine (or “small bowel”) is about 5 to 6 meters
long in a typical person and is full of twists and turns. X-rays do not enable the
physician to view the lining of the intestine, and endoscopes (small cameras attached
to long, thin, flexible poles) can reach only the first third of the small intestine and
can be quite uncomfortable for the patient. The remaining option, surgery, is very
invasive and can be impractical if the physician does not know which part of the
small intestine is affected. Scapa thus urged Iddan to try to come up with a better way
to view the small intestine, but at that time Iddan had no idea how to do it. Ten years
later, Iddan visited the United States again, and his old friend Scapa again inquired
whether there was a technological solution that would provide a better solution for
viewing the small intestine. By this time, very small image sensors— charge-coupled
devices (CCDs)—had been developed in the quest to build small video cameras.
Iddan wondered if perhaps it would be possible to create a very small missile-like
device that could travel through the intestine without a lifeline leading to the outside
of the body. Like the missiles Iddan developed at Rafael, this device would have a
camera “eye.” If the device were designed well, the body’s natural peristaltic action
would propel the camera through the length of the intestine.
5. • A View to the Future . . .
• Colonoscopy was the largest category of the endoscopy market—in the United States
alone, 14 million patients undergo colonoscopy a year, and it was believed that even
more people would undergo screening if screening were more comfortable. Given
thus had the potential of growing market. As of 2015, the U.S. approval for the
Pillcam COLON was limited to “patients who had undergone incomplete
colonoscopies,” citing some results that indicated that the pictures from the camera
pill were less clear than traditional colonoscopy. Many in the industry, however,
suspected that the camera pill would eventually supplant all traditional colonoscopy.
In February of 2014, Dublin-based medical device maker Covidien had acquired
Given Imaging for roughly $860 millioni, and then in early 2015, medical equipment
giant Medtronic acquired Covidien for $49.9 billion.j Given would now have access
to much greater capital resources and larger (and more geographically distributed)
salesforces—if it could continue to get its Pillcams approved for more applications
and in more countries, it was positioned to transform the market for gastrointestinal
endoscopy.
6. OVERVIEW
Innovation can arise from many different sources. It can originate with individuals, as in the familiar image of
the lone inventor or users who design solutions for their own needs. Innovation can also come from the
research efforts of universities, government laboratories and incubators, or private nonprofit organizations. One
primary engine of innovation is firms. Firms are well suited to innovation activities because they typically have
greater resources than individuals and a management system to marshal those resources toward a collective
purpose. Firms also face strong incentives to develop differentiating new products and services, which may
give them an advantage over nonprofit or government-funded entities. An even more important source of
innovation, however, does not arise from any one of these sources, but rather the linkages between them.
Networks of innovators that leverage knowledge and other resources from multiple sources are one of the most
powerful agents of technological advance.1 We can thus think of sources of innovation as composing a
complex system wherein any particular innovation may emerge primarily from one or more components of the
system or the linkages between them (see Figure 2.1).
In the sections that follow, we will first consider the role of creativity as the underlying process for
the generation of novel and useful ideas. We will then consider how creativity is transformed into innovative
outcomes by the separate components of the innovation system (individuals, firms, etc.), and through the
linkages between different components (firms’ relationships with their customers, technology transfer from
universities to firms, etc.).
7. CREATIVITY
Innovation begins with the generation of new ideas. The
ability to generate new and useful ideas is termed
creativity. Creativity is defined as the ability to produce
work that is useful and novel. Novel work must be different
from work that has been previously produced and
surprising in that it is not simply the next logical step in a
series
of known solutions.2 The degree to which a product is
novel is a function both of how different it is from prior work
(e.g., a minor deviation versus a major leap) and of the
audience’s prior experiences.3 A product could be novel to
the person who made it, but known to most everyone else.
In this case, we would call it reinvention. A product could
be novel to its immediate audience, yet be well known
somewhere else in the world. The most creative works are
novel at the individual producer level, the local audience
level, and the broader societal level.4
8. .
As the previous sections indicate, there is a growing recognition of the importance of collaborative
research and development networks for successful innovation.40 Such collaborations include (but are not
limited to) joint ventures, licensing and secondsourcing agreements, research associations, government-
sponsored joint research programs, value-added networks for technical and scientific interchange, and
informal networks.41 Collaborative research is especially important in high-technology sectors, where it is
unlikely that a single individual or organization will possess all of the resources and capabilities necessary
to develop and implement a significant innovation.42 As firms forge collaborative relationships, they
weave a network of paths between them that can act as conduits for information and other resources. By
providing member firms access to a wider range of information (and other resources) than individual firms
possess, interfirm networks can enable firms to achieve much more than they could achieve individually.43
Thus, interfirm networks are an important engine of innovation. Furthermore, the structure of the network
is likely to influence the flow of information and other resources through the network. For example, in a
dense network where there are many potential paths for information to travel between any pair of firms,
information diffusion should be fairly rapid and widespread.
9. Figure 2.6 provides pictures of the worldwide technology alliance network in
1995 and in 2000.44 The mid-1990s saw record peaks in alliance activity as
firms scrambled to respond to rapid change in information technologies. This
resulted in a very large and dense web of connected firms. The network shown
here connects 3,856 organizations, predominantly from North America, Japan,
and Europe. However, there was a subsequent decline in alliance activity
toward the end of the decade that caused the web to diminish in size and
splinter apart into two large components and many small components. The
large component on the left is primarily made up of organizations in the
chemical and medical industries. The large component on the right is primarily
made up of organizations in electronics-based industries. If the size
and density of the collaboration network influences the amount of information
available to organizations that are connected via the network, then the
difference between the network shown for 1995 and the network shown for
2000 could have resulted in a substantial change in the amount of information
that was transmitted between firms. (The strategic implications for a firm’s
position within the network are discussed in
Chapter Eight.)
10. 1. Creativity is the underlying process for innovation. Creativity enables individuals and
organizations to generate new and useful ideas. Creativity is considered a function of intellectual
abilities, knowledge, thinking styles, personality traits, intrinsic motivation, and environment.
2. Innovation sometimes originates with individual inventors. The most prolific
inventors tend to be trained in multiple fields, be highly curious, question previously made
assumptions, and view all knowledge as unified. The most wellknown inventors tend to have both
inventive and entrepreneurial traits.
3. Innovation can also originate with users who create solutions to their own needs. The rise of the
snowboarding industry provides a rich example.
4. Firms’ research and development is considered a primary driver of innovation. In the United
States, firms spend significantly more on R&D than government institutions spend on R&D, and
firms consider their in-house R&D their most important source of innovation.
5. Firms often collaborate with a number of external organizations (or individuals) in their
innovation activities. Firms are most likely to collaborate with customers, suppliers, and
universities, though they also may collaborate with competitors, producers of complements,
government laboratories, nonprofit organizations, and other research institutions.
6. Many universities have a research mission, and in recent years universities have become more
active in setting up technology transfer activities to directly commercialize the inventions of
faculty. Universities also contribute to innovation through the publication of research findings.
11. 7. Government also plays an active role in conducting research and development
(in its own laboratories), funding the R&D of other organizations, and creating
institutions to foster collaboration networks and to nurture start-ups (e.g.,
science parks and incubators). In some countries, government-funded research
and development exceeds that of industry-funded research.
8. Private nonprofit organizations (such as research institutes and nonprofit
hospitals) are another source of innovation. These organizations both perform
their own R&D and fund R&D conducted by others.
9. Probably the most significant source of innovation does not come from
individual organizations or people, but from the collaborative networks that
leverage resources and capabilities across multiple organizations or individuals.
Collaborative networks are particularly important in high-technology sectors.
10. Collaboration is often facilitated by geographical proximity, which can lead
to regional technology clusters.
11. Technology spillovers are positive externality benefits of R&D, such as
when the knowledge acquired through R&D spreads to other organizations.