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Cell Communication4.ppt123457899987523412
- 1. CELL COMMUNICATION Chapter 11 (p.206-225)
- 2. Figure 11.2 Exchange of mating factors Receptor factor a factor Yeast cell, mating type a Yeast cell, mating type Mating New a/ cell 1 2 3 a a a/
- 3. Individual rod-shaped cells Spore-forming structure (fruiting body) Aggregation in progress Fruiting bodies 1 2 3 0.5 mm 2.5 mm Figure 11.3
- 4. Figure 11.4 Plasma membranes Gap junctions between animal cells Plasmodesmata between plant cells (a) Cell junctions (b) Cell-cell recognition
- 5. Figure 11.5a Local signaling Target cell Secreting cell Secretory vesicle Local regulator diffuses through extracellular fluid. (a) Paracrine signaling (b) Synaptic signaling Electrical signal along nerve cell triggers release of neurotransmitter. Neurotransmitter diffuses across synapse. Target cell is stimulated.
- 6. Figure 11.5b Long-distance signaling Endocrine cell Blood vessel Hormone travels in bloodstream. Target cell specifically binds hormone. (c) Endocrine (hormonal) signaling
- 8. Figure 11.7d 2 1 3 Gate closed Ions Plasma membrane Gate open Cellular response Gate closed
- 9. Figure 11.7b G protein-coupled receptor 2 1 3 4 Plasma membrane G protein (inactive) CYTOPLASM Enzyme Activated receptor Signaling molecule Inactive enzyme Activated enzyme Cellular response GDP GTP GDP GTP GTP P i GDP GDP
- 10. Figure 11.7c Signaling molecule (ligand) 2 1 3 4 Ligand-binding site Tyrosines CYTOPLASM Receptor tyrosine kinase proteins (inactive monomers) Signaling molecule Dimer Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr P P P P P P P P P P P P Activated relay proteins Cellular response 1 Cellular response 2 Inactive relay proteins 6 ATP 6 ADP
- 12. Inactive protein kinase 1 Active protein kinase 1 Active protein kinase 2 Active protein kinase 3 Inactive protein kinase 2 Inactive protein kinase 3 ATP ADP ATP ADP ATP ADP PP PP PP P P P P i P i P i Figure 11.10
- 13. Figure 11.11 Adenylyl cyclase Phosphodiesterase AMP H2O ATP P i P cAMP
- 14. Figure 11.12 G protein G protein-coupled receptor Protein kinase A GTP ATP cAMP
- 15. Wild type (with shmoos) Fus3 formin G protein-coupled receptor Formin 2 1 3 4 5 P P P P Formin Formin Fus3 Fus3 Fus3 GDP GTP Microfilament Actin subunit RESULTS CONCLUSION Figure 11.17
- 16. Figure 11.21 Mitochondrion Ced-4 Ced-3 (a) No death signal Active Ced-4 Active Ced-3 Other proteases Nucleases (b) Death signal
- 17. Figure 11.22 Interdigital tissue Cells undergoing apoptosis Space between digits 1 mm