This case involves a 27-year-old female patient presenting with acne vulgaris for 5-6 years. On examination, red maculopapular eruptions, nodules and pustules were observed on her face, forehead, shoulders and back. The patient experienced anxiety, fear, despair and disturbed sleep due to itching. Previous allopathic treatment provided temporary relief. Based on her mental and physical symptoms, including aggravation from sour foods and milk, Psorinum 200 was prescribed in a single dose along with placebo pills. The patient showed marked improvement in her acne and mental state over subsequent follow-ups with increased potencies of Psorinum and placebo maintenance treatment.