Case Based Early Breast Cancer- Role of Radiotherapy
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This document presents a case report of a 43-year-old woman diagnosed with early-stage breast cancer who underwent breast-conserving surgery and chemotherapy followed by radiotherapy. She received intensity-modulated radiation therapy to her left breast in 21 fractions over 4 weeks, with an additional electron boost to ensure adequate dose to the tumor bed. The report discusses the treatment approach in the context of evidence-based guidelines for post-lumpectomy radiotherapy in early-stage breast cancer and factors influencing the decision for radiotherapy after breast-conserving surgery.
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LANDMARK CHEMOTHERAPY AND RADIATION TRIALS IN GASTRIC CANCER.pptx
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This document summarizes several landmark trials investigating chemotherapy and radiation therapy approaches for gastric cancer. Key points include:
- Perioperative chemotherapy is now standard for resectable stage II-IV gastric cancer based on trials like MAGIC and FLOT4 showing improved survival.
- FLOT4 established docetaxel-based chemotherapy as the preferred perioperative regimen.
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10 settles pelvic floor disorders
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Urinary bladder collects urine from the kidney which is then passed through the urethra. Cancer is abnormal growth of cells leading to tumour in urinary bladder. Bladder Cancer is diagnosed with cystoscopy and biopsy . Treatment of Bladder cancer is done as per stage. It includes Radical Cystectomy, Plevic Lymphadenectomy, Ileal conduit, Neobladder as surgical options.
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- 1. RADIOTHERAPY IN EARLY BREAST CANCER :CASE REPORT & DISCUSSION Dr Puneet Seth M.D (Radiation Oncology) Consultant Radiation Oncologist
- 2. EBO = EVIDENCE BASED ONCOLOGY Organization/ Management RADIATION ONCOLOGY SURGICAL ONCOLOGY MEDICAL ONCOLOGY
- 3. CASE REPORT # EBC • Mrs K.K 43 year old normotensive nondiabetic premenopausal lady • P2G2A0, Family history Present (Maternal), Breast Feeding done. • History of lump over the Lt UOQ Breast(Oct 2016). • Clinical Exam: 1.5 cm mass over Left UOQ Breast No palpable LN B/L Axilla & SCF, Rt. Breast-N
- 4. Work-Up • Work-up done at Bombay Hospital, Mumbai under Dr. Prakash Patil (Surg. Onco) • Sono-Mammogram(26.10.2016)BIRAD-5 Hypoechoic irregular mass Lt Breast 8 x 9 mm, 2’ O clock • CXR- N, USG- N, ECG-N, Blood- N • Viral (HIV, Hep B& C): Non-Reactive • FNAC Lt breast (27.10.2016): Ductal carcinoma. • CBC (27.10.2016): Hb 12.5 gm,TLC 11900,Plat Count- Normal, Sr. Creatinine 0.8. • Bone scan (28.10.2016): No e/o skeletal mets.
- 5. Histopathology (HPR) • HPR: Invasive Ductal Carcinoma Grade III Lt Breast • Modified RB Score (3+3+3=9),EIC not seen, PNI/LVI Negative, Skin free, All Axillary LN Neg (0/27). • pT1c N0 M0 [Stage I-A] • Tumor size 1.2 x 0.9 x 0.7 cm, • Margin free • Superior 2.8 cm , Inferior 3.2 cm, Medial 2cm, Lateral 4 cm, Anterior (Skin) 1.2 cm, Post 1.2 cm, • ER/PR/HER-2neu Negative.
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- 12. Image Guided Radiotherapy CBCT
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- 14. LT.LUNG V20< 20%, HEART Mean < 8 Gy
- 15. • Heart: QUANTEC guidelines Mean < 26 (<15% pericarditis) V30 < 46% (<15% pericarditis) Breast Cancer:V25 heart < 10% (<1% risk cadiac mortality @15 years)
- 16. 6 MeV ELECTRON BOOST
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- 24. 3DCRT: CW PORTAL & SCF + AXILLA
- 27. Weighting the Factors Influencing the Decision for PMRT in N1 Disease:
- 28. THANK YOU...TEAM ALEXIS RADIOTHERAPY