CARBOXYMETHYLCELLULOSE PPT.pptx

1. RITU SHRESTHA
ASST.PHARMACIST
National Neuro Centre (NNC)
Moderator
Mr. Pabitra Thapa
CARBOXYMETHYCELLOSE

2. GROUP:
Ophthalmic Lubricant
Brand available in Nepal:
Rrefresh tear drop, lubricant eye drop,
optive drop,

3. Carboxymethycellulose
 Carboxymethylcellulose, an eye lubricant known as artificial tears
 It works similarly to natural tears and provides temporary relief from
burning and discomfort due to the eye's dryness by maintaining proper
lubrication of the eyes and acting as a protectant against further
irritation.

4. Mechanism of action
 binds to the surface of corneal epithelial cells via its glucopyranose
subunits binding to glucose receptors GLUT-1
 The residence time of carboxymethylcellulose bound to corneal cells is
approximately 2 hours as indicated by a short-term binding assay
 Binding to the matrix proteins stimulated corneal epithelial cell
attachment, migration, and re-epithelialization of corneal wounds

5. Indication
Symptomstic relief of burning
Irritation and discomfort
Dryness
Exposure to wind or sun

6. Side Effect
Irritation in eye
Continued eye redness
Pain in eye
Blurred vision
Redness of eye

7. How to use Refresh Tears Drops
Wash hands first.
 To avoid contamination, be careful not to touch the dropper or top of
the ointment tube or let it touch our eye.
Always replace the cap tightly after each use.
Tilt head back, look up, and pull down the lower eyelid to make a
pouch.

9. How to use Refresh Tears Drops
For drops place the dropper directly over the eye and squeeze out 1 or
2 drops as needed.
 Look down and gently close your eye for 1 or 2 minutes.
Place one finger at the corner of the eye near the nose and apply
gentle pressure.
 This will prevent the medication from draining away from the eye.

11. THANK YOU
Acknowledgement
-National Neuro Centre Family