The Big 5 refers to 5 large and dangerous African animals: the lion, leopard, rhinoceros, elephant, and Cape buffalo. These animals were designated as the Big 5 by big game hunters due to the difficulty and danger involved in hunting them. The Lion is the largest cat, the leopard is a spotted cat known for its strength, the rhinoceros has thick armor-like skin, the elephant is the largest land animal, and the Cape buffalo travels in herds and has large, dangerous horns.