Introduction to cognitive enhancers (nootropics) and their role in brain aging. The presentation limits itself in over-the-counter 'nootropics' and aims at providing the tools to safely approach these supplements.

1. Brain Bonanza
1.3. Nootropics
© 2019 Eric Serejski
eric@serejski.com

2. David Petrucci
Jeff Lessans
Luke Markey
Eric Serejski
WHO
Sean Moore
2

3. A word of gratitude
The Experts
Hugh Gordon Eric Johnson
Frederic County
Association of Realtors
Audio-Video Group
Johnson Tien
Social Media Koi Agency
And all of you making this possible.
3

4. 4
Disclaimers
This presentation was created for informational purposes only. The content is not intended to be
a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of
your physician or other qualified health provider with any questions you may have regarding a
medical condition. Never disregard professional medical advice or delay in seeking it because of
something you have read on this Website.
All graphics not created by me are, to the best of my knowledge, public domain and used for sole
purpose of education. Should one not fall in the public domain category, or should proper credit
be missing, please notify me so that the issue can be corrected immediately.

5. Find us at:
https://www.brainbonanza.org/
5

6. Brain Health
6

7. From where to where?

8. Brain - Community
Eating
Supplements
Temperature
Breathing
Diet
Serotonin
Interacting
Nootropics
Microbiome
A good diet
Aging
Medications
B12, D, Mg
Da Vinci
Pairing
Correct deficiencies Smart supplementation
Definition
Functions
Sources
8

9. WHO
New WHO Guidelines recommend
specific interventions
for reducing the risk of cognitive decline and dementia
May 14, 2019
Healthy dietary pattern (e.g. the Mediterranean diet)
https://www.who.int/ageing/
9

10. What are Nootropics?
Substances that improve brain function
Νοῦς τρέπειν
10

11. Discovery
Giurgea. 1973. University of Leuven
Pharmacology of integrative activity of the brain.
Attempt at nootropic concept in
psychopharmacology
Piracetam is a relatively simple compound chemically related to GABA:
GABA
Piracetam
H2N – CH2 – (CH2) 2 – COOH →
CH2 – COH – CH2
N
O
11

12. Corneliu Giurgea
Ilya Prigogine
“The main character of any living system is openness.”
“Man is not going to wait passively for millions of years
before evolution offers him a better brain.”
12

13. “Synonyms”
• Nootropics
• Neuro-enhancers
• Cognitive enhancers
• Cognitive boosters
• Memory enhancers
• Smart drugs
13

14. Functions
• Improve focus and concentration
• Improve motivation
• Improve memory
• Improve mood
• Improve cognition
14

15. Original Definition
• Enhances memory and the ability to learn
• Assists brain function under disruptive conditions
such as lack of oxygen and electroconvulsive shock
• Protects the brain from chemical and physical toxins
like anticholinergic drugs and barbiturates
• Increases natural cognitive processes
• Must be non-toxic to humans, nor stimulate or
depress the brain
15

16. Action
• Increased brain oxygenation
• Modulation of neurochemicals
– Neurotransmitters
– Enzymes
– Hormones
16

17. Acetylcholine
17

18. Central Nervous System
18

19. Autonomic Nervous System
19

20. Nootropics US Trend
6 Bn by 2024
CAGR of 4.2%.
CAGR of 15.7%.
20

21. Google Search Trends
Nootropics
Cognitive enhancers
Baby boomers
2004
20182010
2016
21

22. Natural Sources
Simple versus Stack
Western healing paradigm
Chinese healing paradigm
Ayurvedic healing paradigm
22

23. 23

24. Ginkgo (Ginkgo biloba)Bacopa (Bacopa monnieri)
Lion’s Mane Mushroom
(Hericium erinaceus)
American ginseng
(Panax quinquefolius)
24

25. Simple - Herbal
Name Effect Action
Ginkgo (Ginkgo biloba) Memory, ADHD,
anxiety, and depression
Improves blood flow to the
brain, anti-inflammatory,
antioxidant
Bacopa (Bacopa monnieri) Memory, learning, and
concentration
Neurotransmitter regulator
American ginseng (Panax
quinquefolius)
Memory (short-term),
reaction times
Antioxidant,
neuroprotective, cognitive
enhancer
Lion’s Mane Mushroom
(Hericium erinaceus)
Antidepressant
properties
Neuroprotective, anti-
inflammatory
25

26. Simple – Non-Herbal
Name Effect Action
L-Theanine Memory, learning, and
concentration
Increases levels of
serotonin, dopamine, and
GABA., alters brainwave
patterns
Tryptophan See previous presentation
Vit. B12 See previous presentation
Vit. D See previous presentation
26

27. A word of caution
• Unknown interactions
• Potential side-effects
Many of the herbal components have anti-platelet aggregation properties
27

28. Happy Brain Chemicals
Dopamine
Oxytocin
AcetylcholineSerotonin
Endorphin
28

29. Where?
Company Site Type
Nootropicsexpert nootropicsexpert.com Information
Mindlabpro mindlabpro.com Stack formulation
Performance Lab performancelab.com Stack formulation
29

30. From the individual to the group
• Cognitive enhancement
• Moral enhancement
• Empathy enhancement
• Altruistic enhancement
30

31. References
https://brainbonanza.org
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