Brain Simulator

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The document outlines a project to develop a brain simulator. It discusses brain networks, the theory of neuronal group selection, and a case study on Alzheimer's disease. The goal of the brain simulator is to simulate brain models in order to develop new forms of web intelligence by understanding human intelligence and brain informatics. It proposes ideas for modeling the brain at the macro, meso, and micro levels.

Project – Brain Simulator May 1st, 2010 Speaker : Tony Tseng Advisor : Hsing Mei Web Computing Laboratory Computer Science and Information Engineering Department Fu Jen Catholic University

Outline Introduction Brain Network The Theory of Neuronal Group Selection Case Study - Alzheimer's disease Ideas of Brain Simulator Conclusion and Future Work 2 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

Introduction Web Intelligence Understand Human Intelligence Brain Informatics Simulate Brain Models for new Web Intelligence Step One Brain Simulator 3 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

Brain Network Thalamo-cortical motif Polysynaptic loop structure Diffuse ascending projections 4 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

Thalamo-cortical motif Thalamocortical radiations Directions Thalamus – Cortex Cortex – Cortex Cortex – Thalamus Reentrant mapping Small World Network 5 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

Diffuse ascending projections Value System Neurotransmitters 6 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

The Theory of Neuronal Group Selection Developmental Selection The formation during brain development Neurons fire together wire together 7 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

The Theory of Neuronal Group Selection Experiential Selection Synaptic selection Refining brain maps into internal representations 8 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

The Theory of Neuronal Group Selection Reentrant Mapping This is the process of neuronal integration The thalamo-cortical system 9 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

Case Study - Alzheimer's disease The most common form of dementia Affect 1 in 85 people globally by 2050 Causes Tangles Plaques The neurotransmitter acetylcholine 10 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from AHAF

Case Study - Alzheimer's disease Comparison of a normal aged brain (left) and an Alzheimer's patient's brain (right) 11 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from wikipedia

Case Study - Alzheimer's disease The acetylcholine pathway 12 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from thebrain

Ideas of Brain Simulator 13 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

Ideas of Brain Simulator Macro (Global) Dynamic Core Spatial Temporal Integration of Brian Maps Mesco (Intermediate) Neural Migration Degeneracy Micro (Local) Neurogenesis Synaptogenesis / Synaptic Prunning Myelination 14 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

Ideas of Brain Simulator Analysis of Brain Simulator Simulate Brain Models for new Web Intelligence 15 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

Conclusion and Future Work Brain Network TNGS Ideas of Brain Simulator Future Work Polysynaptic loop structure Results of AD related experiments Modeling our brain simulator Brain-Oriented SLS 16 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

17 ~END~ THANK YOU 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

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Brain Simulator

1. Project – Brain Simulator May 1st, 2010 Speaker : Tony Tseng Advisor : Hsing Mei Web Computing Laboratory Computer Science and Information Engineering Department Fu Jen Catholic University

2. Outline Introduction Brain Network The Theory of Neuronal Group Selection Case Study - Alzheimer's disease Ideas of Brain Simulator Conclusion and Future Work 2 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

3. Introduction Web Intelligence Understand Human Intelligence Brain Informatics Simulate Brain Models for new Web Intelligence Step One Brain Simulator 3 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

4. Brain Network Thalamo-cortical motif Polysynaptic loop structure Diffuse ascending projections 4 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

5. Thalamo-cortical motif Thalamocortical radiations Directions Thalamus – Cortex Cortex – Cortex Cortex – Thalamus Reentrant mapping Small World Network 5 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

6. Diffuse ascending projections Value System Neurotransmitters 6 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

7. The Theory of Neuronal Group Selection Developmental Selection The formation during brain development Neurons fire together wire together 7 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

8. The Theory of Neuronal Group Selection Experiential Selection Synaptic selection Refining brain maps into internal representations 8 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

9. The Theory of Neuronal Group Selection Reentrant Mapping This is the process of neuronal integration The thalamo-cortical system 9 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from Edelman & Tononi, 2000

10. Case Study - Alzheimer's disease The most common form of dementia Affect 1 in 85 people globally by 2050 Causes Tangles Plaques The neurotransmitter acetylcholine 10 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from AHAF

11. Case Study - Alzheimer's disease Comparison of a normal aged brain (left) and an Alzheimer's patient's brain (right) 11 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from wikipedia

12. Case Study - Alzheimer's disease The acetylcholine pathway 12 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net from thebrain

13. Ideas of Brain Simulator 13 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

14. Ideas of Brain Simulator Macro (Global) Dynamic Core Spatial Temporal Integration of Brian Maps Mesco (Intermediate) Neural Migration Degeneracy Micro (Local) Neurogenesis Synaptogenesis / Synaptic Prunning Myelination 14 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

15. Ideas of Brain Simulator Analysis of Brain Simulator Simulate Brain Models for new Web Intelligence 15 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

16. Conclusion and Future Work Brain Network TNGS Ideas of Brain Simulator Future Work Polysynaptic loop structure Results of AD related experiments Modeling our brain simulator Brain-Oriented SLS 16 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

17. 17 ~END~ THANK YOU 08:29 WECO Lab, CSIE Dept., FJU http://www.weco.net

Brain Simulator

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