This document outlines 12 brain rules for optimizing brain function and memory based on Dr. John Medina's research. The rules discuss how exercise, sleep, stress, senses and exploration can impact brain health and memory. Repeated exposure to information through practice and repetition over time is essential for memory consolidation. While multitasking is a myth, stimulating different senses can aid recall. Understanding individual brain differences and providing a safe learning environment also supports development.