The document contains information about planets in the solar system presented through various infographics. It provides details about the planets Mercury, Venus, Earth, Mars, Jupiter, and Saturn. Key facts included are that Mercury is the closest planet to the sun and smallest planet, Earth is the third planet from the sun, Mars is cold despite being red, Jupiter is a gas giant and the largest planet, and Saturn is composed of hydrogen and helium. The document presents this information through multiple infographics with images and short descriptions of each planet.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
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2. Brain Infographics
Planet Mercury is the
closest object to the Sun
Mercury
Mars
Despite being red,
Mars is a cold place
Jupiter
Jupiter is a gas giant
and the biggest planet
Saturn
Saturn is composed of
hydrogen and helium
Earth
Earth is the third planet
from the Sun
Neptune
Neptune is the farthest
planet from the Sun
3. Brain Infographics
01
02
04
03
Mercury is the closest planet to the
Sun and the smallest one
Despite being red, Planet Mars is a
very cold place full of iron oxide dust
Planet Jupiter is a gas giant and the
biggest object in the Solar System
Saturn is the ringed planet. It is
composed of hydrogen and helium
4. Brain Infographics
Planet Jupiter is a gas giant and the
biggest object in the Solar System
Saturn is the ringed planet. It is
composed of hydrogen and helium
Despite being red, Planet Mars is a
very cold place full of iron oxide dust
5. Brain Infographics
Mercury is the
closest planet to
the Sun and the
smallest one
Jupiter is a gas
giant and the
biggest object in
the Solar System
It is the ringed planet.
It is composed of
hydrogen and helium
Despite being red,
Planet Mars is a
very cold place
Saturn
Mercury
Mars
Jupiter
6. Brain Infographics
Saturn
Saturn is composed of
hydrogen and helium
Earth
Earth is the third planet
from the Sun
Neptune
Neptune is the farthest
planet from the Sun
Mercury is the closest
object to the Sun
Mercury
01 02
03 04
7. Brain Infographics
Saturn
Saturn is composed of
hydrogen and helium
03
Earth
Earth is the third planet
from the Sun
01
Neptune
Neptune is the farthest
planet from the Sun
02
Planet Mercury is the
closest object to the Sun
Mercury
04
Mars
Despite being red,
Mars is a cold place
05
Jupiter
Jupiter is a gas giant
and the biggest planet
06
8. Brain Infographics
Saturn
Saturn is composed of
hydrogen and helium
03
Earth
Earth is the third planet
from the Sun
01
Neptune
Neptune is the farthest
planet from the Sun
02
Planet Mercury is the
closest object to the Sun
Mercury
04
Mars
Despite being red,
Mars is a cold place
05
Jupiter
Jupiter is a gas giant
and the biggest planet
06
9. Brain Infographics
Earth
Earth is the third
planet from the Sun
It’s the farthest
planet from the Sun
Mars
Despite being red,
Mars is a cold place
It’s the closest
object to the Sun
Mercury Neptune
10. Brain Infographics
Earth
Earth is the third
planet from the Sun
01
It’s the farthest
planet from the Sun
02
Mars
Despite being red,
Mars is a cold place
03
It’s the closest
object to the Sun
Mercury
04
Neptune
11. Brain Infographics
Saturn
Saturn is composed of
hydrogen and helium
Earth
Earth is the third planet
from the Sun
Neptune
Neptune is the farthest
planet from the Sun
Planet Mercury is the
closest object to the Sun
Mercury
Mars
Despite being red,
Mars is a cold place
12. Brain Infographics
Earth
Earth is the third
planet from the Sun
Neptune
It’s the farthest
planet from the Sun
Mars
Despite being red,
Mars is a cold place
It’s the closest
object to the Sun
Mercury
13. Brain Infographics
01 02 03 04
Neptune Mercury
Earth Mars
Earth is the third
planet from the Sun
It’s the farthest
planet from the Sun
Despite being red,
Mars is a cold place
It’s the closest
object to the Sun
14. Brain Infographics
Neptune Mercury
Earth Mars
Earth is the third
planet from the Sun
It’s the farthest
planet from the Sun
Despite being red,
Mars is a cold place
It’s the closest
object to the Sun
15. Brain Infographics
Earth
Earth is the
third planet
from the Sun
Neptune
It’s the
farthest planet
from the Sun
Mars
Despite being
red, Mars is a
cold place
Mercury is the
closest object
to the Sun
Mercury
16. Brain Infographics
Mercury is the
closest planet to
the Sun and the
smallest one
Jupiter is a gas
giant and the
biggest object in
the Solar System
It is the ringed planet.
It is composed of
hydrogen and helium
Despite being red,
Planet Mars is a
very cold place
Saturn Mercury
Mars Jupiter
17. Brain Infographics
01
02
03
04
Saturn is composed of
hydrogen and helium
Earth is the third planet
from the Sun
Neptune is the farthest
planet from the Sun
Planet Mercury is the
closest object to the Sun
18. Brain Infographics
02
04
01
03
Earth
Earth is the third
planet from the Sun
It’s the farthest
planet from the Sun
Mars
Despite being red,
Mars is a cold place
It’s the closest
object to the Sun
Mercury Neptune
19. Brain Infographics
Mercury is the
closest planet to
the Sun and the
smallest one
Jupiter is a gas
giant and the
biggest object in
the Solar System
It is the ringed planet.
It is composed of
hydrogen and helium
Despite being red,
Planet Mars is a
very cold place
Saturn Mercury
Mars Jupiter
20. Brain Infographics
It’s the farthest
planet from the Sun
Mars
Despite being red,
Mars is a cold place
It’s the closest
object to the Sun
Mercury Neptune
21. Saturn
Saturn is composed of
hydrogen and helium
Earth
Earth is the third planet
from the Sun
Neptune
Neptune is the farthest
planet from the Sun
Planet Mercury is the
closest object to the Sun
Mercury
Mars
Despite being red,
Mars is a cold place
Jupiter
Jupiter is a gas giant
and the biggest planet
Brain Infographics
02
04
06
01
03
05
22. Brain Infographics
Saturn
It’s composed of
hydrogen and
helium
Earth
Earth is the third
planet from the
Sun
Neptune
Neptune is the
farthest planet
from the Sun
Planet Mercury is
the closest object
to the Sun
Mercury Mars
Despite being red,
But Mars is a cold
place
Jupiter
Jupiter is a gas
giant and the
biggest planet
23. Brain Infographics
Saturn
Saturn is composed of
hydrogen and helium
Earth
Earth is the third planet
from the Sun
Neptune
Neptune is the farthest
planet from the Sun
Planet Mercury is the
closest object to the Sun
Mercury
Mars
Despite being red,
Mars is a cold place
Jupiter
Jupiter is a gas giant
and the biggest planet
24. Brain Infographics
Earth
Earth is the
third planet
from the Sun
Neptune
It’s the
farthest planet
from the Sun
Mars
Despite being
red, Mars is a
cold place
Mercury is the
closest object
to the Sun
Mercury
25. 03
01
02
04
Brain Infographics
Earth is the third
planet from the Sun
Venus has a
beautiful name
Despite being red,
Mars is a cold place
Mercury is a small
planet
26. Brain Infographics
Mercury is the
closest planet to
the Sun and the
smallest one
Jupiter is a gas
giant and the
biggest object in
the Solar System
Saturn is the ringed
planet. It is composed
of hydrogen and
helium
Despite being red,
Planet Mars is a
very cold place
Saturn Mercury
Mars Jupiter
50% 90%
25% 75%
27. Brain Infographics
Earth
Earth is the third
planet from the Sun
It’s the farthest
planet from the Sun
Mars
Despite being red,
Mars is a cold place
It’s the closest
object to the Sun
Mercury Neptune
28. Brain Infographics
Saturn
It’s composed
of hydrogen
and helium
Earth
Earth is the
third planet
from the Sun
Neptune
Neptune is the
farthest planet
from the Sun
Mercury is the
closest object
to the Sun
Mercury
Mars
Despite being
red, Mars is a
cold place
29. Brain Infographics
Saturn
Saturn is composed of
hydrogen and helium
Earth
Earth is the third planet
from the Sun
Neptune
Neptune is the farthest
planet from the Sun
Planet Mercury is the
closest object to the Sun
Mercury
Mars
Despite being red,
Mars is a cold place
Jupiter
Jupiter is a gas giant
and the biggest planet
03
01 02
04 05 06
30. Brain Infographics
01 02
03 04
Planet Mercury is the
closest object to the Sun
Mercury
Mars
Despite being red,
Mars is a cold place
Earth
Earth is the third planet
from the Sun
Neptune
Neptune is the farthest
planet from the Sun
31. Brain Infographics
Mars
Jupiter
Saturn
03
01
02
Despite being red, Planet Mars is a
very cold place full of iron oxide dust
Planet Jupiter is a gas giant and the
biggest object in the Solar System
Saturn is the ringed planet. It is
composed of hydrogen and helium
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