This document discusses what makes Boston's start-up scene special, including its intellectual capital from top universities and research institutions, access to advisors, angel investors, accelerators, and venture capital funds, and presence of successful companies in industries like life sciences, energy, mobile technology, and more. It highlights Boston's leadership in metrics like patents and NIH funding per capita and notes the dense concentration of innovators and start-ups in clusters like Kendall Square and the emerging innovation district in Allston.