DESCRIBES THE BIOLOGICAL ACTIVITIES OF RESVERATROl

1. OUTLINES
• INTRODUCTION
• BIOLOGICALACTIVITIES OF
RESVERATROL
• REVESRATROLAND
GASTROINTESTINAL CANCER
– MECHANISM OF ACTION
• ROLE IN DIFFERENT GI CANCER
• CONCLUSION

2.  Belongs to a class of polyphenolic compounds called stilbenes
 Some types of plants produce Resveratrol and other stilbenes in response to:
stress, injury, fungal infection, and ultraviolet (UV) radiation (Bastianetto et al., 2015)
 It is a fat soluble compound that occurs in a trans and a cis configuration
 Both cis and trans resveratrol also occur as glucosides (bound to a glucose molecule)
 Resveratrol-3-O-beta-glucoside is also called piceid
RESVERATROL: General information

3.  Resveratrol possesses a wide range of biological properties, among them
antioxidant, cardioprotective, neuroprotective, anti-inflammatory and
anticancer activities (Orallo et al., 2006).
Biological Activities of Resveratrol
RESVERATROL AND
GASTROINTESTINAL CANCER
 Resveratrol is becoming recognized as an anti-cancer drug; it has powerful
anti-cancer activity in various cancer cells and organs (Park et al., 2017).

4. The main mechanisms of action are:
 inducing apoptosis and autophagy
 regulating TGF-signaling pathways to limit epithelial cell growth
 inhibiting cell invasion, migration, and angiogenesis
 improving DNA repair (to repair mitochondria and DNA);
 modulating NLRP (Nod-like receptor protein), NF-kB, and Toll-like receptor
(TLR) signaling pathways to modulate the secretion of various cytokines; (Filosa
et al., 2018).
Resveratrol Mechanism of action

5.  Moreover, resveratrol can inhibit urease synthesis by H. pylori, thus reducing the pH of the GI
mucosal niche, contributing to the elimination of H. pylori bacteria.
 Furthermore, it is well known that resveratrol can regulate the bacterial protein synthesis of
several virulence factors (e.g. CagA) that promote H. pylori-induced gastric cancer
Resveratrol Mechanism of action

6.  Resveratrol anti-cancer activity via the aforementioned mechanisms prevents colorectal
cancer, esophageal cancer, pancreatic cancer, gastric cancer, oral cancer, biliary tract
cancer, and hepatocellular cancer
 It has also been shown that resveratrol’s anti-proliferative activity involves the stimulation
of apoptosis within cancer cells, a probable mechanism for chemotherapeutic agents to
destroy cancerous cells (Kim et al., 2019).
Resveratrol and GI cancer

7.  Little is known about the absorption and clearance of resveratrol, the identities of its
metabolic products, or its effects on the liver
 The research on resveratrol has focused on its short-term effects and has been
dominated by in vitro studies on non-human models
 Its role as a potentiator of breast carcinomas may significantly limit its use, even for its
proven benefits
 Its main dietary source is red wine, which is not only extremely variable, but possibly
harmful to be recommending increased intakes of red wine to the population at this
point
CONCLUSION

8. Bastianetto, S., Ménard, C., & Quirion, R. (2015). Neuroprotective action of resveratrol. Biochimica et Biophysica Acta
(BBA)-Molecular Basis of Disease, 1852(6), 1195-1201.
Filosa, S., Di Meo, F., & Crispi, S. (2018). Polyphenols-gut microbiota interplay and brain neuromodulation. Neural
regeneration research, 13(12), 2055.
Kim, D. U., Kwak, B., & Kim, S. W. (2019). Phosphodiesterase 4B is an effective therapeutic target in colorectal
cancer. Biochemical and biophysical research communications, 508(3), 825-831.
Orallo, F. (2006). Comparative studies of the antioxidant effects of cis-and trans-resveratrol. Current medicinal
chemistry, 13(1), 87-98.
Park, E. J., & Pezzuto, J. M. (2015). The pharmacology of resveratrol in animals and humans. Biochimica et Biophysica
Acta (BBA)-Molecular Basis of Disease, 1852(6), 1071-1113.
Park, S., Lim, J., Kim, J. R., & Cho, S. (2017). Inhibitory effects of resveratrol on hepatitis B virus X protein-induced
hepatocellular carcinoma. Journal of veterinary science, 18(4), 419-429.
REFERENCES

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