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Bezwada Biomedical LLC

    Corporate Overview
            &
   Technology Platforms


     Rao S. Bezwada
Company Overview

                                                • Over 20 US and
                                                  European Patents
                                  Innovation      filed
                                    driven
                                   company      • 0ver 20 presentations
                                                  in international
                                                  conferences



                                        Develops
               Bezwada                 Absorbable     • Over 250 new
                                       Monomers         monomers developed
            Biomedical LLC                and
                                        Polymers




                                    R&D         • Lab Scale
                                 locations in
                                                • Pilot Scale
                                  US A and
                                    India       • Analytical facilities




For more information, please visit us at
    www.bezwadabiomedical.com
Our Facilities

• 15000 square feet state of the art facility in India
• 6000 square feet corporate R&D facility in New Jersey, USA


  Our lab facility in India           Our lab facility in USA
Our Facilities




Total: 25 employees
• 3 PhD
• 6 Masters
• 8 BS level
Our US Facilities
Bezwada Biomedical Associates in India
Bezwada Biomedical Associates in India
Our Capabilities




Pilot Plant Facilities
• 10 Gallons to 50 Gallons
Production Units:
• 55 gallons to 500 gallons
Our Analytical Capabilities: US and India
                  Our analytical capabilities include:
                   UV-Visible Spectroscopy
                   Infrared Spectroscopy
                   GC
                   HPLC
                   TLC
                   Karl Fischer
                   Differential Scanning Calorimetry
                   Solution Viscometry
                   Gel Permeation Chromatography
Expansion of Bezwada Biomedical facilities in India
Expansion of Bezwada Biomedical facilities in India
Absorbable Technology Platforms


                       Absorbable
                      Polyurethanes




    Functionalized                    Functionalized
     Amino acids                         Drugs




                     Absorbable
                     Technology
                      Platforms


    Functionalized                    Anti-microbial
      Phenolics




                       NO releasing
                         Drugs
Technology Platforms: Attributes and Applications

                             • Key Attributes
                               • Derived from hydrolytically degradable isocyanates
                               • Tunable physical, mechanical properties and hydrolytic degradation profile
Absorbable Polyurethanes       • Releases safe and biocompatible molecules upon degradation
                             • Applications
                               • Tissue Adhesive and Sealants, Wound healing, Tissue Engineering, Coatings, Drug delivery


                             • Key Attributes
                               • Derived from drugs and safe and biocompatible molecules
Absorbable Polymers from       • Tunable hydrolytic degradation profile
                               • Releases drug molecule as such along with safe and biocompatible molecules upon degradation
  Functionalized Drugs       • Applications
                               • Controlled drug delivery, Pain management, Wound healing


                             • Key Attributes
                               • Based on functionalized Triclosan
                               • Controllable release of Triclosan molecules along with safe and biocompatible molecules
     Anti-Microbial          • Applications
                               • Anti-microbial coatings
                               • Anti-microbial formulation


                             • Key Attributes
                               • Drug molecules and NO releasing moiety attached via hydrolytically degradable linker
                               • Controllable release profiles
   NO releasing Drugs        • Applications
                               • Treatment of Glaucoma, Osteoarthritis, Cardio-metabolic and inflammatory disorders
                               • NO releasing coatings


                             • Key Attributes
                               • Derived from natural phenolic molecules such as flavonoids, chalcones and coumarins
Absorbable Polymers from       • Incorporates beneficial attributes of natural molecules in the polymer backbone
                               • Tunable hydrolytic degradation profiles
 Functionalized Phenolics    • Applications
                               • Drug delivery, cosmetics, radiation stable medical devices, anti-microbial coatings


                             • Key Attributes
                               • Derived from amino acids functionalized with safe and biocompatible molecules
Absorbable Polymers from       • Tunable physical, mechanical properties and hydrolytic degradation profile
                               • Releases safe and biocompatible molecules upon degradation
Functionalized Amino Acids   • Applications
                               • Drug Delivery, Stent and Stent Coatings, Scaffolds
Advantages of our Technology over Prior Art



• Controlled degradation profiles
• Tunable physical and mechanical properties
• Derived from safe and biocompatible molecules
• Degradation products safe and biocompatible
• Bioactive molecule remains unaffected
• Enhance Bioavailability of Drugs
• Increased circulation time of drug
Benefits to customer

• Access to world class facilities for synthesis,
characterization, scale-up and processing of both
generic and novel absorbable polymers for medical
applications.

• Molecular-design-to-manufacturing of high-purity
monomers and polymers for biomedical applications.

• Access to new and generic high-purity absorbable
polymers with physical and mechanical properties
tuned to meet challenging customer specifications.
Our Brochures and Catalogs
What can we offer




 Access to
   Our        Custom     Contract      Due
Technology   Synthesis   Research   Diligence
Bezwada Biomedical Corporate Overview

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Bezwada Biomedical Corporate Overview

  • 1. Bezwada Biomedical LLC Corporate Overview & Technology Platforms Rao S. Bezwada
  • 2. Company Overview • Over 20 US and European Patents Innovation filed driven company • 0ver 20 presentations in international conferences Develops Bezwada Absorbable • Over 250 new Monomers monomers developed Biomedical LLC and Polymers R&D • Lab Scale locations in • Pilot Scale US A and India • Analytical facilities For more information, please visit us at www.bezwadabiomedical.com
  • 3. Our Facilities • 15000 square feet state of the art facility in India • 6000 square feet corporate R&D facility in New Jersey, USA Our lab facility in India Our lab facility in USA
  • 4. Our Facilities Total: 25 employees • 3 PhD • 6 Masters • 8 BS level
  • 8. Our Capabilities Pilot Plant Facilities • 10 Gallons to 50 Gallons Production Units: • 55 gallons to 500 gallons
  • 9. Our Analytical Capabilities: US and India Our analytical capabilities include:  UV-Visible Spectroscopy  Infrared Spectroscopy  GC  HPLC  TLC  Karl Fischer  Differential Scanning Calorimetry  Solution Viscometry  Gel Permeation Chromatography
  • 10. Expansion of Bezwada Biomedical facilities in India
  • 11. Expansion of Bezwada Biomedical facilities in India
  • 12. Absorbable Technology Platforms Absorbable Polyurethanes Functionalized Functionalized Amino acids Drugs Absorbable Technology Platforms Functionalized Anti-microbial Phenolics NO releasing Drugs
  • 13. Technology Platforms: Attributes and Applications • Key Attributes • Derived from hydrolytically degradable isocyanates • Tunable physical, mechanical properties and hydrolytic degradation profile Absorbable Polyurethanes • Releases safe and biocompatible molecules upon degradation • Applications • Tissue Adhesive and Sealants, Wound healing, Tissue Engineering, Coatings, Drug delivery • Key Attributes • Derived from drugs and safe and biocompatible molecules Absorbable Polymers from • Tunable hydrolytic degradation profile • Releases drug molecule as such along with safe and biocompatible molecules upon degradation Functionalized Drugs • Applications • Controlled drug delivery, Pain management, Wound healing • Key Attributes • Based on functionalized Triclosan • Controllable release of Triclosan molecules along with safe and biocompatible molecules Anti-Microbial • Applications • Anti-microbial coatings • Anti-microbial formulation • Key Attributes • Drug molecules and NO releasing moiety attached via hydrolytically degradable linker • Controllable release profiles NO releasing Drugs • Applications • Treatment of Glaucoma, Osteoarthritis, Cardio-metabolic and inflammatory disorders • NO releasing coatings • Key Attributes • Derived from natural phenolic molecules such as flavonoids, chalcones and coumarins Absorbable Polymers from • Incorporates beneficial attributes of natural molecules in the polymer backbone • Tunable hydrolytic degradation profiles Functionalized Phenolics • Applications • Drug delivery, cosmetics, radiation stable medical devices, anti-microbial coatings • Key Attributes • Derived from amino acids functionalized with safe and biocompatible molecules Absorbable Polymers from • Tunable physical, mechanical properties and hydrolytic degradation profile • Releases safe and biocompatible molecules upon degradation Functionalized Amino Acids • Applications • Drug Delivery, Stent and Stent Coatings, Scaffolds
  • 14. Advantages of our Technology over Prior Art • Controlled degradation profiles • Tunable physical and mechanical properties • Derived from safe and biocompatible molecules • Degradation products safe and biocompatible • Bioactive molecule remains unaffected • Enhance Bioavailability of Drugs • Increased circulation time of drug
  • 15. Benefits to customer • Access to world class facilities for synthesis, characterization, scale-up and processing of both generic and novel absorbable polymers for medical applications. • Molecular-design-to-manufacturing of high-purity monomers and polymers for biomedical applications. • Access to new and generic high-purity absorbable polymers with physical and mechanical properties tuned to meet challenging customer specifications.
  • 16. Our Brochures and Catalogs
  • 17. What can we offer Access to Our Custom Contract Due Technology Synthesis Research Diligence