Oral Mucositis (OM) is a severely debilitating condition that occurs secondary to radiotherapy and chemotherapy in cancer patients. It is important to maintain oral cleansing, reduce the risk of oral infections, and promote oral comfort. Oral care has been suggested to play a role in oral mucositis progression. The evidence on which agents can help was scarce so far. For the first time, we have two network meta-analyses (published in 2020) that have compared various oral care solutions and ranked them based on their beneficial role in preventing or reducing the severity of oral mucositis. Benzydamine mouthwash along with traditional curcumin & honey can prevent or reduce the severity of oral mucositis. This evidence can be utilized for a wider range of applications in dentistry – even in non-cancer patients.
Benzydamine anti-inflammatory, anesthetic mouthwash: all evidence - ICPA Heal...ICPA Care
High-quality evidence and international guidelines recommend the use of Benzydamine hydrochloride mouthwash as an anti-inflammatory agent in highly inflammatory conditions, such as oral mucositis resulting from cancer therapy.
Use of chlorhexidine mouthwash to crush the covid 19 pandemicICPA Care
Along with safe distancing, proper use of masks, hand sanitization, and eye wear, chlorhexidine can reduce virus transmission effectively, safeguard the doctors and clinics, offices and households from indoor transmission. It can also help hospitalized patients to reduce their oropharyngeal viral load effectively.
The study says that chlorhexidine is a simple and safe addition to current COVID‐19 prevention guidelines and may significantly reduce disease spread.
Short-term improvement of clinical parameters and microbial diversity in peri...M ALTAMIMI
Indocyanine green-mediated photodynamic therapy is effective against chronic periodontitis. Here, we evaluated the efficiency of indocyanine green-based adjunctive antimicrobial photodynamic therapy in non- surgical treatment of chronic periodontitis patients
Benzydamine anti-inflammatory, anesthetic mouthwash: all evidence - ICPA Heal...ICPA Care
High-quality evidence and international guidelines recommend the use of Benzydamine hydrochloride mouthwash as an anti-inflammatory agent in highly inflammatory conditions, such as oral mucositis resulting from cancer therapy.
Use of chlorhexidine mouthwash to crush the covid 19 pandemicICPA Care
Along with safe distancing, proper use of masks, hand sanitization, and eye wear, chlorhexidine can reduce virus transmission effectively, safeguard the doctors and clinics, offices and households from indoor transmission. It can also help hospitalized patients to reduce their oropharyngeal viral load effectively.
The study says that chlorhexidine is a simple and safe addition to current COVID‐19 prevention guidelines and may significantly reduce disease spread.
Short-term improvement of clinical parameters and microbial diversity in peri...M ALTAMIMI
Indocyanine green-mediated photodynamic therapy is effective against chronic periodontitis. Here, we evaluated the efficiency of indocyanine green-based adjunctive antimicrobial photodynamic therapy in non- surgical treatment of chronic periodontitis patients
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
The role of fluoride and chlorhexidine in the prevention of dental cariesDeepa jinan
a detailed description of the role of fluoride and chlorhexidine in the prevention of dental caries, including mehanism of action, modes/ routes of administration, dose recommendations, comparisons.
We in Chinthamani Laser Dental Clinic & Implant Centre ,cover every speciality and subspeciality in dentistry so that all kind of your dental problems can be treated efficiently and effectively.
Contact us:
Chinthamani Laser Dental Clinic & Implant Centre
1/464,Mount Poonamallee High Road,
Iyyapanthangal,
Chennai-56
Phone no.044-43800059 , 92 83 786776
Email:
chinthamanidental@gmail.com,
dr_mrgvl@gmail.com
Website:
www.chinthamanilaserdentalclinic.com
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
The role of fluoride and chlorhexidine in the prevention of dental cariesDeepa jinan
a detailed description of the role of fluoride and chlorhexidine in the prevention of dental caries, including mehanism of action, modes/ routes of administration, dose recommendations, comparisons.
We in Chinthamani Laser Dental Clinic & Implant Centre ,cover every speciality and subspeciality in dentistry so that all kind of your dental problems can be treated efficiently and effectively.
Contact us:
Chinthamani Laser Dental Clinic & Implant Centre
1/464,Mount Poonamallee High Road,
Iyyapanthangal,
Chennai-56
Phone no.044-43800059 , 92 83 786776
Email:
chinthamanidental@gmail.com,
dr_mrgvl@gmail.com
Website:
www.chinthamanilaserdentalclinic.com
Minimum intervention dentistry is a concept based on a better understanding of the caries process and development of the carious process and the development of new diagnostic technologies and adhesives, bioactive restorative materials.
Management of Radiation Toxicity in H & Ndrmadhup1
Management of Radiation Toxicities in head and neck cancer. Radiation is the most important mode of treatment for head and neck cancer patients. It causes both acute and late side effects. Oral mucositis an early or acute reaction which is the limiting factor in all patients. Its management guidelines has been given by MASCC and been updated time to time. Counselling is very important. General oral care and dental prophylaxis is very important before starting the treatment. High end planning in the form of IMRT may help in reducing the OM. Delineation of oral mucosa during RT may help. Use of Glutamine, Honey is also recommended. Benzydamine gargle to be used. Chlorhexidine gargles are not recommended. Proper control of Pain and infection is of para mount importance. Radiation dermatitis is also an acute side effects and its management involves general skin care, washing, topical steroids and some cream based upon aloe vera. Xerostomia is also a late complication which can be addressed by dysphagia optimized IMRT technique which has shown positive results in randomized trial. Symptomatic patient may be asked to use water frequently as well as some artificial saliva preparation in day today life. Dysphagia is another late side effect can be managed by dietary counselling. Other late side effects include Trismus, sub cutaneous fibrosis of neck and late stages lymphedema. It management includes prevention and treatment by pentoxyphylline and vitamin E.
Repeated exercises after radiotherapy is must.
Candidiasis is a fungal infection caused by yeasts from the genus Candida. It is commonly called oral candidiasis or thrush when it affects the mouth. It is one of the common side effects associated with the long term use of steroid inhalers. Nebulizing therapy with corticosteroids is widely accepted treatment approach for patients with acute exacerbations of Chronic Obstructive Pulmonary Disease. The other side effects of steroid inhalers include hoarseness of voice and dysphonia, which are usually ignorable. We report this case of 74 year old male patient who was on metered dosage inhaler and nebulizer therapy with corticosteroid and presented with oral candidiasis. If oral thrush develops, treatment with oral fluconazole or nystatin mouth wash is beneficial. Proper patient education by the clinical pharmacist to the patient regarding safe and effective usage of inhalers and nebulizers especially corticosteroids can minimize these drug related problems.
Treatment of oral submucous fibrosis can be done by using various natural remedies and plant extracts. The article describes some of these therapies for the treatment of OSMF
A Modality in the Diagnosis and Treatment of Oral Candidiasisasclepiuspdfs
Candidiasis as an infection spread all over the oral cavity finds the appropriate conditions to show the clinical appearance, mainly in patients with reduced immune status. For the purpose of facilitating the case diagnosis of case studies, supported also in literature, the study aims at the application of blue methylene as an indicator of Candida colonies in various areas of oral cavity mucosa. Identification with blue methylene is a simple procedure that reduces the microbiological stages of planting and testing the candidate’s candidacy, shortening the timing of diagnosis, and performing this procedure at the dental chair. Based on the literature, though few, in number, the references indicate Lugol’s application, the 2% iodine solution as a candidate for treatment of candidiasis previously detected with blue methylene in the patients involved in the studies referred to in the literature. Iodine delivery in patients is progressively carried out, ranging from 1 drop to day, 2.5 mg, to a maximum of 5 drops/day, 12.5 mg, proportionally divided by day. Patients involved declare for lack of iodine allergies, and during subtype in this therapy, were kept under control for systemic sensations previously unpublished but based on literature, as sleeping disturbances, worries in the nutritional constituents of the individual diet, or any other concern.
The Importance of Community Nursing Care.pdfAD Healthcare
NDIS and Community 24/7 Nursing Care is a specific type of support that may be provided under the NDIS for individuals with complex medical needs who require ongoing nursing care in a community setting, such as their home or a supported accommodation facility.
International Cancer Survivors Day is celebrated during June, placing the spotlight not only on cancer survivors, but also their caregivers.
CANSA has compiled a list of tips and guidelines of support:
https://cansa.org.za/who-cares-for-cancer-patients-caregivers/
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
Empowering ACOs: Leveraging Quality Management Tools for MIPS and BeyondHealth Catalyst
Join us as we delve into the crucial realm of quality reporting for MSSP (Medicare Shared Savings Program) Accountable Care Organizations (ACOs).
In this session, we will explore how a robust quality management solution can empower your organization to meet regulatory requirements and improve processes for MIPS reporting and internal quality programs. Learn how our MeasureAble application enables compliance and fosters continuous improvement.
COVID-19 PCR tests remain a critical component of safe and responsible travel in 2024. They ensure compliance with international travel regulations, help detect and control the spread of new variants, protect vulnerable populations, and provide peace of mind. As we continue to navigate the complexities of global travel during the pandemic, PCR testing stands as a key measure to keep everyone safe and healthy. Whether you are planning a business trip, a family vacation, or an international adventure, incorporating PCR testing into your travel plans is a prudent and necessary step. Visit us at https://www.globaltravelclinics.com/
Trauma Outpatient Center is a comprehensive facility dedicated to addressing mental health challenges and providing medication-assisted treatment. We offer a diverse range of services aimed at assisting individuals in overcoming addiction, mental health disorders, and related obstacles. Our team consists of seasoned professionals who are both experienced and compassionate, committed to delivering the highest standard of care to our clients. By utilizing evidence-based treatment methods, we strive to help our clients achieve their goals and lead healthier, more fulfilling lives.
Our mission is to provide a safe and supportive environment where our clients can receive the highest quality of care. We are dedicated to assisting our clients in reaching their objectives and improving their overall well-being. We prioritize our clients' needs and individualize treatment plans to ensure they receive tailored care. Our approach is rooted in evidence-based practices proven effective in treating addiction and mental health disorders.
ICH Guidelines for Pharmacovigilance.pdfNEHA GUPTA
The "ICH Guidelines for Pharmacovigilance" PDF provides a comprehensive overview of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines related to pharmacovigilance. These guidelines aim to ensure that drugs are safe and effective for patients by monitoring and assessing adverse effects, ensuring proper reporting systems, and improving risk management practices. The document is essential for professionals in the pharmaceutical industry, regulatory authorities, and healthcare providers, offering detailed procedures and standards for pharmacovigilance activities to enhance drug safety and protect public health.
Cold Sores: Causes, Treatments, and Prevention Strategies | The Lifesciences ...The Lifesciences Magazine
Cold Sores, medically known as herpes labialis, are caused by the herpes simplex virus (HSV). HSV-1 is primarily responsible for cold sores, although HSV-2 can also contribute in some cases.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
Benzydamine mouthwash, curcumin and honey prevent and reduce oral mucositis severity converted
1. Benzydamine Mouthwash, Curcumin And Honey
Prevent/ Reduce Oral Mucositis Severity
Oral Mucositis (OM) is a severely debilitating condition that occurs
secondary to radiotherapy and chemotherapy in cancer patients. It is
important to maintain oral cleansing, reduce the risk of oral infections, and
promote oral comfort. Oral care has been suggested to play a role in oral
mucositis progression. The evidence on which agents can help was scarce
so far. For the first time, we have two network meta-analyses (published in
2020) that have compared various oral care solutions and ranked them
based on their beneficial role in preventing or reducing the severity of oral
mucositis. Benzydamine mouthwash along with traditional curcumin & honey
can prevent or reduce the severity of oral mucositis. This evidence can be
utilized for a wider range of applications in dentistry – even in non-cancer
patients.
What is Mucositis?
Mucositis applies to the consequences secondary to cancer therapy –
chemotherapy and/ or radiation therapy; specifically, the mucosal damage
occurring in the oral cavity; pharyngeal, laryngeal, oesophagal regions; and
other gastrointestinal tract areas. It occurs in about 20% to 40% of patients
undergoing conventional chemotherapy and almost all patients who receive
head and neck radiation therapy (H&NRT).
2. What is OM?
OM is a severely disabling and commonly seen early chemotherapy and
radiotherapy effect. OM can trigger an inability to tolerate food or fluids, which
leads to malnutrition, dehydration, and weight loss.
How do we classify OM based on severity?
Depending on the severity, OM is grouped as
1. Tolerable mucositis (grade 1 and 2)
2. Intolerable mucositis (grade 3 or higher).
What are the consequences of intolerable mucositis?
Intolerable OM (grade 3 or higher) deserves more attention as large painful
ulcers characterize it. Pain leads to reduced food intake or nutritional
deficiencies. Also, mucositis induced dysphagia further reduces patients’
nutritional intake, leading to malnutrition and secondary bacterial and fungal
infections. As a result, the condition worsens, resulting in systemic symptoms
such as fatigue, anorexia and depression.
Drugs in OM:
Various drugs have been used to prevent and treat OM, but none have
achieved a satisfactory level.
Oral care and mouthwashes to prevent/ reduce the severity of OM:
Recently, oral care has been suggested to play a role in OM progression.
Different oral care solutions, such as chlorhexidine, benzydamine, sucralfate,
povidone-iodine, and honey, have been found to prevent mucositis or reduce
its severity.
Mouthwashes can maintain a clean oral environment and reduce the number of
bacteria in the oral cavity, thus reducing the risk of infection due to mucosal
damage, preventing OM in cancer patients.
Mouthwashes are economical and easy to use and are readily accepted by
patients. Plenty of research has happened regarding the use of mouthwashes
to prevent OM. However, we have two problems. First, we have a wide variety
of mouthwashes. Second, most studies focus on comparing mouthwash and
placebo; thus, there is a lack of direct comparison between different
mouthwashes, which means that it is difficult to provide evidence to guide
clinical practice.
3. Evidence on oral care solutions:
Systematic reviews and meta-analyses till the year 2020 that examined the
effects of the various oral care solutions on OM could only give out limited
evidence because classical meta-analysis methods did not allow comparisons
of multiple products.
In 2020, Bayesian network meta-analysis, a method combining all available
direct and indirect evidence on the relative treatment effects, enabling a
unified analysis of all randomized controlled trials was carried out for the first
time.
Bayesian network analysis (2020):
The study used appropriate statistical methods to merge direct and indirect
comparisons and sort different mouthwashes quantitatively to obtain the
optimal protocol.
The advanced methodology provided the basis for selecting the right
mouthwash to prevent intolerable OM development. The four most likely
efficacious interventions are chamomile, honey, curcumin, and benzydamine
mouthwashes.
Conclusion: According to the analysis of rank probabilities, chamomile,
honey, curcumin, and benzydamine mouthwashes are the most beneficial in
preventing intolerable OM.
Commonly available mouthwash benzydamine hydrochloride is a nonsteroidal
drug with proven topical anti-inflammatory, analgesic, anaesthetic, and
antimicrobial activities. Benzydamine reduces radiation-induced toxicity by
suppressing selected pro-inflammatory cytokine production – one of the
significant OM mechanisms.
International guidelines and recommendations:
International guidelines in this regard were published in 2004 and then
updated in 2007 and 2014. The MASCC/ISOO clinical practise guidelines
(2014) recommend that benzydamine mouthwash be used to prevent OM in
patients with cancer (level I evidence) – this is in agreement with the latest
Bayesian network analysis (2020).
What is a ‘level I’ evidence?
Level I consists of evidence that has more than one randomized controlled
trials without any significant flaws.
4. Relevance to dental practice:
Benzydamine mouthwash has been in use for many years. Now, the literature
gives the much needed evidence-based confidence to the practitioners that if
benzydamine can reduce the severity and provide comfort in a condition as
severe as OM from cancer therapy, it can undoubtedly provide comfort in less
severe, day-to-day cases of mucosal erythema, burning and discomfort while
having food and fluids.
1. Any mucosal burning, pain or discomfort.
2. Trauma from orthodontic braces, oral surgery appliances where the
patient can not apply the local anaesthetic gel, topical steroid gel etc.
3. Ulcers over a wide area inside the mouth
4. Hot food/ beverage or allergic reaction to a food ingredient leading to
burning and discomfort that urgently needs relief.
Curcumin and Honey:
Another network meta-analysis, also published in 2020, ranked curcumin,
honey and benzydamine as the top three interventions to prevent OM or
reduce its severity. Hence, in both the latest meta-analyses, two things have
become clear. A commonly available mouthwash like benzydamine and
homecare with curcumin and honey can benefit OM patients greatly in
improving their quality of life.
References:
1. Yu YY, Deng JL, Jin XR, Zhang ZZ, Zhang XH, Zhou X. Effects of nine
oral care solutions on the prevention of oral mucositis: A network meta-
analysis of randomized controlled trials. Medicine. 2020;99:16(e19661).
2. Zhang, X., Sun, D., Qin, N., Liu, M., Zhang, J., & Li, X. (2020).
Comparative prevention potential of 10 mouthwashes on intolerable oral
mucositis in cancer patients: A Bayesian network analysis. Oral
Oncology, 107, 104751. doi:10.1016/j.oraloncology.2020.104751
3. Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire
DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, Raber-Durlacher JE,
Sonis ST, Elad S; Mucositis Guidelines Leadership Group of the
Multinational Association of Supportive Care in Cancer and International
Society of Oral Oncology (MASCC/ISOO). MASCC/ISOO clinical practice
guidelines for the management of mucositis secondary to cancer
therapy. Cancer. 2014 May 15;120(10):1453-61. doi:
10.1002/cncr.28592. Epub 2014 Feb 25. Erratum in: Cancer. 2015 Apr
15;121(8):1339. PMID: 24615748; PMCID: PMC4164022.
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