OK Compounding in Skiatook, Oklahoma produces a transdermal gel to treat migraine headaches as an alternative to oral medications. The gel delivers medications like sumatriptan, ketamine, and gabapentin through the skin to avoid digestive issues and directly target pain, working by suspending drugs in a gel that helps penetrate the skin. Transdermal delivery provides relief for many migraine patients who have problems with oral drugs.

2.  Based in Skiatook, Oklahoma, OK Compounding
provides non-oral treatments for a variety of medical
conditions. OK Compounding, led by Dr. Gary Lee
and Christopher Parks, produces a transdermal gel
that treats migraine headaches.
One of the most debilitating chronic or reoccurring
illnesses, migraines cause severe head pain as well as
nausea, dizziness, and sensitivity to stimuli. Although
oral treatments tend to be the most common
intervention for this condition, the Agency for
Healthcare Research and Quality has determined
that non-oral agents can also provide relief when
given as treatments for acute migraine.

3.  This offers hope to the many patients
who experience digestive distress when
given oral medications, or for whom oral
medication may cause liver problems or
lack effectiveness due to first-pass
elimination.

4.  Transdermal delivery, by contrast, bypasses
the digestive system and targets the area
where the patient experiences pain. The
process works by suspending the
medication in an enhanced pluronic
lecithin organogel (PLO gel) that assists the
drug in penetrating the skin. For migraine
patients, transdermally delivered drugs may
include sumatriptan, ketamine,
gabapentin, odansetron, and fluribopfren.
These compounds work together to address
blood vessel dilation, inflammation, and
neuropathic pain.