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Autism Ontario provides detailed information, services and supports to children and youth with autism. This and many more such organizations are working to increase the awareness about the autism in the society.
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It is necessary for people to manage their HVAC (Heating ,Ventilation and Air-Conditioning) system to get the best performance. The Programmable Thermostats installed in the systems to regulate the in-house temperatures so you don`t have to rely on Air-Conditioners and heaters. It is one of the best ways to save dollars on HVAC.
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There are many possible symptoms of Asperger's syndrome, children with asperger's symptoms generally have difficulty interacting with others and often are awkward in social situations. These typically appears first in childhood.
Physiotherapy can help you strengthen your bones, as well as your muscles. It can prevent bone thinning, reduce falls and help you manage chronic back pain. When you see a physiotherapist, they will assess your problem, give you advice and give you physical treatment.
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Nowadays, dental problems are the part of peoples life. There are some common dental problems that can be very detrimental, so we have to be cautious enough to learn and interpret ways to prevent them. Brushing your teeth twice a day, daily flossing and going for regular dental check-ups are some preventive steps.
It is important for everyone to be aware of home invasions. You need to be aware of your neighborhood activities. Home invasions in Edmonton have been increasing and so have their violence. You all need to prevent and stop a breaking and entering crime from happening to you.
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There are number of hot tub spa companies available in Edmonton, Alberta, Canada. Their hot tub spas are proudly handcrafted in Canada to be superior in craftsmanship, energy efficiency, engineering and safety. You can choose them for an amazing bathing experience.
It is necessary for people to manage their HVAC (Heating ,Ventilation and Air-Conditioning) system to get the best performance. The Programmable Thermostats installed in the systems to regulate the in-house temperatures so you don`t have to rely on Air-Conditioners and heaters. It is one of the best ways to save dollars on HVAC.
Autism News is the most comprehensive source for news coverage about autism spectrum disorder. Autism news portals are available that help you know about advancements in the medical field and what developments are being made by experts.
There are a number of benefits of using A-frame sign as they are the most useful advertisement tools for your business or event. The important benefit of advertising with it that it allows for flexibility in the message being sent out..
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Install your sump pump by the professionalbrackdod25
Sump pumps are very useful for homes as it remove water build-up from basements. You must ensure that you get your sump pump installed by the professional because there are specific dangers pertaining to the placement and installation of these devices.
The page headings play the most important role for a webpage in the website. It helps search engines to understand the content you offer. It is the important part of your website’s SEO. It also helps visitors to understand your webpage content.
If you are looking for best granite countertops, granite countertops Edmonton offer a variety of designs in different types of stones such as granite, marble and quartz for home and kitchen.
There are many possible symptoms of Asperger's syndrome, children with asperger's symptoms generally have difficulty interacting with others and often are awkward in social situations. These typically appears first in childhood.
Physiotherapy can help you strengthen your bones, as well as your muscles. It can prevent bone thinning, reduce falls and help you manage chronic back pain. When you see a physiotherapist, they will assess your problem, give you advice and give you physical treatment.
There are many dental clinics available in Edmonton, Calgary that provides the service of dental crowns or dental caps. The dental caps are important as they are protecting a weak tooth from decay, the installation of a dental bridge, covering a large filling, and more.
Fire Resistant Jacket provides best fire protection and allowing you to work effectively. There are different types of fire resistant jacket specifically designed for the trade and other labour intensive tasks.
There are lots of updates and changes occurring in search engine algorithm in the year 2014. There are lots of things that SEO professionals need to consider and learn from these changes. For more details, please visit http://rapidboostmarketing.com/things-2014-taught-us-about-seo/
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Power sources and appliances also need to be treated with care, as they can be dangerous when not used correctly. There are many electricity safety tips can be useful to stay safe within the home. You need to turn off electrical items when they are not in use. You need to look after your cables and wires and do not mix water and electricity. To keep your children safe and free from accidents caused by electricity, it is important to take proper safety measures at home.
Nowadays, dental problems are the part of peoples life. There are some common dental problems that can be very detrimental, so we have to be cautious enough to learn and interpret ways to prevent them. Brushing your teeth twice a day, daily flossing and going for regular dental check-ups are some preventive steps.
It is important for everyone to be aware of home invasions. You need to be aware of your neighborhood activities. Home invasions in Edmonton have been increasing and so have their violence. You all need to prevent and stop a breaking and entering crime from happening to you.
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Physical Therapy Can Treat Causes of Dizzinesspatboone
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Senior physiotherapy Calgary can help get the life of older people back on track. Trained physiotherapists, help older people in improving their strength, balance, coordination, flexibility and pain levels. These factors further contribute towards helping aged adults to maintain their health, well-being, functional ability and independence.
Get the Best Treatment From Physiotherapy Edmontonpatboone
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.