Aydin Reagent Bioconjugation Intro
•Download as PPTX, PDF•
2 likes•540 views
1. Aydin Reagents are new 'click chemistry' reagents that use di-aldehyde conjugation for amine bioconjugation. 2. The di-aldehyde conjugation is fast, stable, efficient, and can occur under aqueous and physiological conditions without the need for a catalyst. 3. The di-aldehyde group can react with amine, hydrazine, and oxyamine groups to conjugate to a wide range of molecules like fluorophores, drugs, proteins and nanoparticles.
Report
Share
Report
Share
Recommended
Ch.10.elements, compounds and mixtures
The document discusses elements, compounds, and mixtures. It defines a pure substance as having definite chemical and physical properties. Elements are pure substances that cannot be broken down further, while compounds are pure substances made of two or more elements chemically bonded together. Mixtures are combinations of pure substances that are not chemically bonded and can be separated physically. It then provides examples to distinguish between elements, compounds, and mixtures.
Matter part 1 types 2013
There are three main ways to classify matter: elements, compounds, and mixtures. Elements are substances that cannot be broken down further, examples include anything on the periodic table. Compounds are substances made of two or more elements bonded together in a fixed ratio, such as NaCl or CO2. Mixtures are combinations of elements or compounds that can be combined in any ratio, and can be either homogeneous, where the composition is uniform throughout, or heterogeneous, where the composition varies. Common examples of each are provided.
Atom economy - "Green Chemistry Project"
This document discusses the concept of atom economy, which is a measure of efficiency in chemical reactions. It is defined as the ratio of the total weight of atoms in the products to the total weight of atoms in the reactants. A higher atom economy means more of the reactants are incorporated into the desired products and less is wasted. The document provides an example reaction and calculations to show how atom economy is determined. It explains that both yield and atom economy should be considered when designing green chemical processes in order to minimize waste.
Chapter 9.3 : Limiting Reactants and Percent Yield
This document discusses limiting reactants, theoretical yield, actual yield, and percent yield in chemical reactions. It defines limiting reactant as the reactant that limits the amounts of other reactants that can combine and the amount of product that can form. It provides examples of how to use before-during-after charts to determine the limiting and excess reactants. It also demonstrates how to calculate theoretical yield, actual yield, and percent yield, and provides a sample problem calculating percent yield.
Atom Economy - Comenius Project
Green chemistry aims to reduce waste and hazardous substances in chemical processes. One principle of green chemistry is maximizing atom economy, which refers to the conversion efficiency of a chemical process in terms of how many atoms from the starting materials end up in the final products, with no wasted atoms. Atom economy can be calculated and improved to make chemical processes more sustainable and reduce waste.
Amalgam vs composites
This document compares the two most commonly used restorative dental materials: amalgam and composites. Amalgam is a metallic material that is a mixture of silver alloy and mercury. It has high compressive strength, excellent wear resistance, and is economical. However, it is non-aesthetic and can corrode. Composites are highly cross-linked polymeric materials that are bonded to tooth structure. They offer aesthetic restorations and conserve tooth structure, but have drawbacks like polymerization shrinkage, increased time to cure, and difficulty finishing and polishing. The document discusses the compositions, applications, advantages, and disadvantages of both amalgam and composites to provide a thorough comparison of these important restorative materials.
Methoxy group
The document discusses methoxy groups, which consist of a methyl group bound to oxygen. It provides examples of methoxy compounds like dimethyl ether and anisole. It then describes Zeisel's method for estimating the number of methoxy groups in a compound, which involves reaction with hydroiodic acid to liberate the methoxy group as methyl iodide, which precipitates as silver iodide upon reaction with silver nitrate. The amount of silver iodide precipitate corresponds to the number of methoxy groups present. It also briefly discusses the preparation of ethers through dehydration of alcohols and the Williamson ether synthesis reaction.
Lecture 12.3- Limiting Reagents and Percent Yield
The document discusses key concepts in chemistry including:
1) Limiting reagents and how the amount of one reactant determines how much product can be formed in a reaction.
2) Theoretical yield refers to the maximum product that can form based on stoichiometry while actual yield is what is obtained in the lab.
3) Percent yield compares the actual yield to the theoretical yield and indicates the reaction's efficiency. It is never higher than 100%.
Recommended
Ch.10.elements, compounds and mixtures
The document discusses elements, compounds, and mixtures. It defines a pure substance as having definite chemical and physical properties. Elements are pure substances that cannot be broken down further, while compounds are pure substances made of two or more elements chemically bonded together. Mixtures are combinations of pure substances that are not chemically bonded and can be separated physically. It then provides examples to distinguish between elements, compounds, and mixtures.
Matter part 1 types 2013
There are three main ways to classify matter: elements, compounds, and mixtures. Elements are substances that cannot be broken down further, examples include anything on the periodic table. Compounds are substances made of two or more elements bonded together in a fixed ratio, such as NaCl or CO2. Mixtures are combinations of elements or compounds that can be combined in any ratio, and can be either homogeneous, where the composition is uniform throughout, or heterogeneous, where the composition varies. Common examples of each are provided.
Atom economy - "Green Chemistry Project"
This document discusses the concept of atom economy, which is a measure of efficiency in chemical reactions. It is defined as the ratio of the total weight of atoms in the products to the total weight of atoms in the reactants. A higher atom economy means more of the reactants are incorporated into the desired products and less is wasted. The document provides an example reaction and calculations to show how atom economy is determined. It explains that both yield and atom economy should be considered when designing green chemical processes in order to minimize waste.
Chapter 9.3 : Limiting Reactants and Percent Yield
This document discusses limiting reactants, theoretical yield, actual yield, and percent yield in chemical reactions. It defines limiting reactant as the reactant that limits the amounts of other reactants that can combine and the amount of product that can form. It provides examples of how to use before-during-after charts to determine the limiting and excess reactants. It also demonstrates how to calculate theoretical yield, actual yield, and percent yield, and provides a sample problem calculating percent yield.
Atom Economy - Comenius Project
Green chemistry aims to reduce waste and hazardous substances in chemical processes. One principle of green chemistry is maximizing atom economy, which refers to the conversion efficiency of a chemical process in terms of how many atoms from the starting materials end up in the final products, with no wasted atoms. Atom economy can be calculated and improved to make chemical processes more sustainable and reduce waste.
Amalgam vs composites
This document compares the two most commonly used restorative dental materials: amalgam and composites. Amalgam is a metallic material that is a mixture of silver alloy and mercury. It has high compressive strength, excellent wear resistance, and is economical. However, it is non-aesthetic and can corrode. Composites are highly cross-linked polymeric materials that are bonded to tooth structure. They offer aesthetic restorations and conserve tooth structure, but have drawbacks like polymerization shrinkage, increased time to cure, and difficulty finishing and polishing. The document discusses the compositions, applications, advantages, and disadvantages of both amalgam and composites to provide a thorough comparison of these important restorative materials.
Methoxy group
The document discusses methoxy groups, which consist of a methyl group bound to oxygen. It provides examples of methoxy compounds like dimethyl ether and anisole. It then describes Zeisel's method for estimating the number of methoxy groups in a compound, which involves reaction with hydroiodic acid to liberate the methoxy group as methyl iodide, which precipitates as silver iodide upon reaction with silver nitrate. The amount of silver iodide precipitate corresponds to the number of methoxy groups present. It also briefly discusses the preparation of ethers through dehydration of alcohols and the Williamson ether synthesis reaction.
Lecture 12.3- Limiting Reagents and Percent Yield
The document discusses key concepts in chemistry including:
1) Limiting reagents and how the amount of one reactant determines how much product can be formed in a reaction.
2) Theoretical yield refers to the maximum product that can form based on stoichiometry while actual yield is what is obtained in the lab.
3) Percent yield compares the actual yield to the theoretical yield and indicates the reaction's efficiency. It is never higher than 100%.
atom economy
green chemistry : is the design of chemical products and process that reduce the eliminate the use and generation of hazardous substances
atom economy : the maximum amount of all raw material end up into desired products and a minimum amount of waste product is produced. the mass of product that we want as a% of the mass of all products
examples :
importance :
type of reactions
t
Chapter12 Section01 Edit
The document discusses balanced chemical equations and stoichiometry. It explains that balanced chemical equations can be used to determine the quantities of reactants and products involved in a chemical reaction, just like a recipe specifies quantities for ingredients and food made. Chemists use stoichiometry and balanced equations to calculate how much reactant is needed or product will be formed. Mass and atoms are conserved in every chemical reaction according to the principle of mass conservation.
chemistry calculations percent yield and atom economy
Percentage yield is a number between 0-100 that indicates how successful a chemical reaction was at producing the desired product. It is calculated by taking the mass of product actually produced and dividing it by the theoretical mass expected based on the limiting reactant.
Atom economy is also a number between 0-100 that indicates how efficiently a reaction uses reactants to produce the desired product. It is calculated by taking the mass of the desired product and dividing it by the total mass of all products.
Factors like incomplete reactions, losses during workup, and impure products can decrease the percentage yield of a reaction.
Improving the Synthesis of Lidocaine_2014_Odneal_Aills_Jeffery
The document describes efforts to optimize the synthesis of the drug lidocaine. Researchers improved the yield of a precursor from 50-66% to over 90% by determining the optimal concentration using lab arrays. They then sought to eliminate the use of the carcinogen toluene as a solvent and minimize reaction time in producing lidocaine from the precursor. Testing various solvents, temperatures, and heating methods, they achieved a 90% yield of lidocaine from the precursor in just 10 minutes using a microwave instead of the traditional 90 minutes with toluene.
Limiting reactants
This document provides examples of how to calculate the limiting reactant and maximum product formed in chemical reactions. It demonstrates calculating moles of each reactant, comparing reactant ratios to determine the limiting reactant, and using mole ratios to calculate maximum product. An alternative method is proposed to systematically solve these types of problems.
Class 8 the language of chemistry-5
Chemical equations must be balanced to obey the law of conservation of mass. This law states that matter is neither created nor destroyed in a chemical reaction, only transformed. To balance an equation, one counts the number of atoms of each element on both sides of the reaction. If the numbers are not equal, coefficients are placed in front of formulas to balance the atoms. For example, the equation H2 + Cl2 → HCl is balanced by adding a coefficient of 2 in front of HCl to make the chlorine atoms equal on both sides of the reaction. Balancing chemical equations ensures the law of conservation of mass is followed.
OrganoLinx Aydin Reagent Bioconjugation Introduction
OrganoLinx Aydin Reagent Bioconjugation Introduction
Dr. Frank Sullivan - Early diagnosis of lung cancer
The document discusses early diagnosis of lung cancer through potential screening programs utilizing low-dose CT scans and blood-based biomarkers. It describes:
1) Current poor outcomes of lung cancer diagnosed at late stages and potential for improved survival if detected earlier. A case study is presented of a patient whose cancer was found too late.
2) Ongoing research into using low-dose CT screening and blood-based biomarkers individually and together to detect lung cancer at earlier stages. Early results from a large Scottish trial combining CT and biomarkers show promising increases in operable cancers detected.
3) Key information needs and roles of primary care physicians in potential future organized lung cancer screening programs, as identified through focus groups in Ontario.
Brentuximab vedotin .Reem Ibrahim
Brentuximab vedotin is an antibody-drug conjugate used to treat Hodgkin lymphoma and systemic anaplastic large cell lymphoma. It consists of the monoclonal antibody cAC10 linked to the microtubule inhibitor MMAE. When the antibody binds to CD30 proteins on lymphoma cells, the complex is internalized and MMAE is released, disrupting the microtubule network and causing cell death. Brentuximab vedotin allows targeted delivery of the cytotoxic agent to minimize side effects compared to conventional chemotherapy. Common side effects include neuropathy, nausea, fatigue, and low blood cell counts.
Lecture 10
This document discusses phase II drug metabolism and prodrugs. Phase II metabolism involves conjugation reactions that attach groups to drugs or metabolites, making them more water soluble and able to be excreted. Common conjugation reactions are acylation, sulfation, and conjugation with amino acids, glucuronic acid, glutathione, and mercapturic acid. Prodrugs are inactive compounds that are metabolized in the body to active drugs. They can increase solubility, improve taste, reduce toxicity, and target drug delivery. Prodrugs are classified as bioprecursors, which are converted to the active drug through metabolism, or carriers, which link an active drug to a species to modify its properties.
Applications of click chemistry in drug discovery
his article focus mainly on click chemistry mechanisms and its applications, click chemistry is an easy way to generate substances quickly and reliably by joining small units together, with this ease of use mechanism, click chemistry as found its applications in various technologies especially in drug discovery ,medicinal chemistry, enzyme activity, chemistry natural products, material science, polymers, nanotechnology and bioconjugation
Organic Compounds
The document discusses the four main types of organic compounds: lipids, proteins, carbohydrates, and nucleic acids. It defines each type, their compositions, functions, and examples. Lipids are made up of carbon, hydrogen, and oxygen and include fats, oils, and waxes. They store and release energy. Proteins contain carbon, hydrogen, oxygen, and nitrogen, and perform essential functions in the body like structure, movement, and immunity. Carbohydrates provide energy and are made of carbon, hydrogen, and oxygen in monosaccharides, disaccharides and polysaccharides like glucose, starch and cellulose. Nucleic acids contain carbon, hydrogen, oxygen, nitrogen and phosphorus and include DNA and RNA
ppt of Bacterial genetic system
This document summarizes three mechanisms of genetic transfer in bacteria: transformation, conjugation, and transduction. Transformation involves the uptake of naked DNA by a bacterial cell. Conjugation is the transfer of genetic material between bacteria via cell-to-cell contact through a pilus. Transduction is the process by which bacteriophage viruses transmit DNA between bacteria. These three mechanisms allow for genetic recombination and diversity in bacterial populations.
Targeted drug delivery systems By Vishnu Datta M
Introduction
Advantages and disadvantages
Basic biological process and events in Targeted delivery
Organic or Inorganic?
The document identifies various molecules and determines whether they are organic or inorganic. It considers molecules like water, carbon dioxide, sodium carbonate, ethane, glucose, ribose, amino acids, glycerol, fatty acids, dipeptides, and triglycerides to be organic; and molecules like oxygen, sodium hydrogencarbonate, potassium hydrogencarbonate to be inorganic based on the presence or absence of carbon in their structure.
Targeted drug delivery system
This document discusses targeted drug delivery systems. It defines targeted drug delivery as selectively delivering medication to its site of action to increase concentration in tissues of interest while reducing it in other tissues, improving efficacy and reducing side effects. The document outlines various strategies for targeted delivery including passive, active, ligand-mediated and physical targeting. It also describes several types of targeted delivery systems including liposomes, dendrimers, nanotubes, nanoshells and others. The goal is to achieve the desired pharmacological response at selected sites with minimal side effects.
ORGANIC CHEMISTRY FOR CLASS XI CBSE
This document provides an overview of organic chemistry. It discusses the structures of organic compounds including Lewis structures, condensed structures, and bond line representations. It also describes three-dimensional representations using wedges and dashes. The document classifies organic compounds as acyclic, alicyclic, or aromatic. It discusses IUPAC nomenclature rules for naming organic compounds including hydrocarbons, functional groups, and isomers. Finally, it briefly touches on reaction mechanisms and bond cleavage in organic reactions.
Organic Compounds
The document discusses organic compounds and their properties. It defines organic compounds as those containing carbon and highlights that carbon can bond with many other elements. It also distinguishes between organic and inorganic compounds, monomer and polymers, and provides examples of element, compounds and mixtures. The document encourages reflecting on what was learned about organic compounds using a KWL chart.
Mechanics:- Simple and Compound Pendulum
a compound pendulum is a physical system with a more complex structure than a simple pendulum, incorporating its mass distribution and dimensions into its oscillatory motion around a fixed axis. Understanding its dynamics involves principles of rotational mechanics and the interplay between gravitational potential energy and kinetic energy. Compound pendulums are used in various scientific and engineering applications, such as seismology for measuring earthquakes, in clocks to maintain accurate timekeeping, and in mechanical systems to study oscillatory motion dynamics.
Signatures of wave erosion in Titan’s coasts
The shorelines of Titan’s hydrocarbon seas trace flooded erosional landforms such as river valleys; however, it isunclear whether coastal erosion has subsequently altered these shorelines. Spacecraft observations and theo-retical models suggest that wind may cause waves to form on Titan’s seas, potentially driving coastal erosion,but the observational evidence of waves is indirect, and the processes affecting shoreline evolution on Titanremain unknown. No widely accepted framework exists for using shoreline morphology to quantitatively dis-cern coastal erosion mechanisms, even on Earth, where the dominant mechanisms are known. We combinelandscape evolution models with measurements of shoreline shape on Earth to characterize how differentcoastal erosion mechanisms affect shoreline morphology. Applying this framework to Titan, we find that theshorelines of Titan’s seas are most consistent with flooded landscapes that subsequently have been eroded bywaves, rather than a uniform erosional process or no coastal erosion, particularly if wave growth saturates atfetch lengths of tens of kilometers.
More Related Content
What's hot
atom economy
green chemistry : is the design of chemical products and process that reduce the eliminate the use and generation of hazardous substances
atom economy : the maximum amount of all raw material end up into desired products and a minimum amount of waste product is produced. the mass of product that we want as a% of the mass of all products
examples :
importance :
type of reactions
t
Chapter12 Section01 Edit
The document discusses balanced chemical equations and stoichiometry. It explains that balanced chemical equations can be used to determine the quantities of reactants and products involved in a chemical reaction, just like a recipe specifies quantities for ingredients and food made. Chemists use stoichiometry and balanced equations to calculate how much reactant is needed or product will be formed. Mass and atoms are conserved in every chemical reaction according to the principle of mass conservation.
chemistry calculations percent yield and atom economy
Percentage yield is a number between 0-100 that indicates how successful a chemical reaction was at producing the desired product. It is calculated by taking the mass of product actually produced and dividing it by the theoretical mass expected based on the limiting reactant.
Atom economy is also a number between 0-100 that indicates how efficiently a reaction uses reactants to produce the desired product. It is calculated by taking the mass of the desired product and dividing it by the total mass of all products.
Factors like incomplete reactions, losses during workup, and impure products can decrease the percentage yield of a reaction.
Improving the Synthesis of Lidocaine_2014_Odneal_Aills_Jeffery
The document describes efforts to optimize the synthesis of the drug lidocaine. Researchers improved the yield of a precursor from 50-66% to over 90% by determining the optimal concentration using lab arrays. They then sought to eliminate the use of the carcinogen toluene as a solvent and minimize reaction time in producing lidocaine from the precursor. Testing various solvents, temperatures, and heating methods, they achieved a 90% yield of lidocaine from the precursor in just 10 minutes using a microwave instead of the traditional 90 minutes with toluene.
Limiting reactants
This document provides examples of how to calculate the limiting reactant and maximum product formed in chemical reactions. It demonstrates calculating moles of each reactant, comparing reactant ratios to determine the limiting reactant, and using mole ratios to calculate maximum product. An alternative method is proposed to systematically solve these types of problems.
Class 8 the language of chemistry-5
Chemical equations must be balanced to obey the law of conservation of mass. This law states that matter is neither created nor destroyed in a chemical reaction, only transformed. To balance an equation, one counts the number of atoms of each element on both sides of the reaction. If the numbers are not equal, coefficients are placed in front of formulas to balance the atoms. For example, the equation H2 + Cl2 → HCl is balanced by adding a coefficient of 2 in front of HCl to make the chlorine atoms equal on both sides of the reaction. Balancing chemical equations ensures the law of conservation of mass is followed.
What's hot (6)
chemistry calculations percent yield and atom economy
chemistry calculations percent yield and atom economy
Improving the Synthesis of Lidocaine_2014_Odneal_Aills_Jeffery
Improving the Synthesis of Lidocaine_2014_Odneal_Aills_Jeffery
Viewers also liked
OrganoLinx Aydin Reagent Bioconjugation Introduction
OrganoLinx Aydin Reagent Bioconjugation Introduction
Dr. Frank Sullivan - Early diagnosis of lung cancer
The document discusses early diagnosis of lung cancer through potential screening programs utilizing low-dose CT scans and blood-based biomarkers. It describes:
1) Current poor outcomes of lung cancer diagnosed at late stages and potential for improved survival if detected earlier. A case study is presented of a patient whose cancer was found too late.
2) Ongoing research into using low-dose CT screening and blood-based biomarkers individually and together to detect lung cancer at earlier stages. Early results from a large Scottish trial combining CT and biomarkers show promising increases in operable cancers detected.
3) Key information needs and roles of primary care physicians in potential future organized lung cancer screening programs, as identified through focus groups in Ontario.
Brentuximab vedotin .Reem Ibrahim
Brentuximab vedotin is an antibody-drug conjugate used to treat Hodgkin lymphoma and systemic anaplastic large cell lymphoma. It consists of the monoclonal antibody cAC10 linked to the microtubule inhibitor MMAE. When the antibody binds to CD30 proteins on lymphoma cells, the complex is internalized and MMAE is released, disrupting the microtubule network and causing cell death. Brentuximab vedotin allows targeted delivery of the cytotoxic agent to minimize side effects compared to conventional chemotherapy. Common side effects include neuropathy, nausea, fatigue, and low blood cell counts.
Lecture 10
This document discusses phase II drug metabolism and prodrugs. Phase II metabolism involves conjugation reactions that attach groups to drugs or metabolites, making them more water soluble and able to be excreted. Common conjugation reactions are acylation, sulfation, and conjugation with amino acids, glucuronic acid, glutathione, and mercapturic acid. Prodrugs are inactive compounds that are metabolized in the body to active drugs. They can increase solubility, improve taste, reduce toxicity, and target drug delivery. Prodrugs are classified as bioprecursors, which are converted to the active drug through metabolism, or carriers, which link an active drug to a species to modify its properties.
Applications of click chemistry in drug discovery
his article focus mainly on click chemistry mechanisms and its applications, click chemistry is an easy way to generate substances quickly and reliably by joining small units together, with this ease of use mechanism, click chemistry as found its applications in various technologies especially in drug discovery ,medicinal chemistry, enzyme activity, chemistry natural products, material science, polymers, nanotechnology and bioconjugation
Organic Compounds
The document discusses the four main types of organic compounds: lipids, proteins, carbohydrates, and nucleic acids. It defines each type, their compositions, functions, and examples. Lipids are made up of carbon, hydrogen, and oxygen and include fats, oils, and waxes. They store and release energy. Proteins contain carbon, hydrogen, oxygen, and nitrogen, and perform essential functions in the body like structure, movement, and immunity. Carbohydrates provide energy and are made of carbon, hydrogen, and oxygen in monosaccharides, disaccharides and polysaccharides like glucose, starch and cellulose. Nucleic acids contain carbon, hydrogen, oxygen, nitrogen and phosphorus and include DNA and RNA
ppt of Bacterial genetic system
This document summarizes three mechanisms of genetic transfer in bacteria: transformation, conjugation, and transduction. Transformation involves the uptake of naked DNA by a bacterial cell. Conjugation is the transfer of genetic material between bacteria via cell-to-cell contact through a pilus. Transduction is the process by which bacteriophage viruses transmit DNA between bacteria. These three mechanisms allow for genetic recombination and diversity in bacterial populations.
Targeted drug delivery systems By Vishnu Datta M
Introduction
Advantages and disadvantages
Basic biological process and events in Targeted delivery
Organic or Inorganic?
The document identifies various molecules and determines whether they are organic or inorganic. It considers molecules like water, carbon dioxide, sodium carbonate, ethane, glucose, ribose, amino acids, glycerol, fatty acids, dipeptides, and triglycerides to be organic; and molecules like oxygen, sodium hydrogencarbonate, potassium hydrogencarbonate to be inorganic based on the presence or absence of carbon in their structure.
Targeted drug delivery system
This document discusses targeted drug delivery systems. It defines targeted drug delivery as selectively delivering medication to its site of action to increase concentration in tissues of interest while reducing it in other tissues, improving efficacy and reducing side effects. The document outlines various strategies for targeted delivery including passive, active, ligand-mediated and physical targeting. It also describes several types of targeted delivery systems including liposomes, dendrimers, nanotubes, nanoshells and others. The goal is to achieve the desired pharmacological response at selected sites with minimal side effects.
ORGANIC CHEMISTRY FOR CLASS XI CBSE
This document provides an overview of organic chemistry. It discusses the structures of organic compounds including Lewis structures, condensed structures, and bond line representations. It also describes three-dimensional representations using wedges and dashes. The document classifies organic compounds as acyclic, alicyclic, or aromatic. It discusses IUPAC nomenclature rules for naming organic compounds including hydrocarbons, functional groups, and isomers. Finally, it briefly touches on reaction mechanisms and bond cleavage in organic reactions.
Organic Compounds
The document discusses organic compounds and their properties. It defines organic compounds as those containing carbon and highlights that carbon can bond with many other elements. It also distinguishes between organic and inorganic compounds, monomer and polymers, and provides examples of element, compounds and mixtures. The document encourages reflecting on what was learned about organic compounds using a KWL chart.
Viewers also liked (14)
OrganoLinx Aydin Reagent Bioconjugation Introduction
OrganoLinx Aydin Reagent Bioconjugation Introduction
Dr. Frank Sullivan - Early diagnosis of lung cancer
Dr. Frank Sullivan - Early diagnosis of lung cancer
Recently uploaded
Mechanics:- Simple and Compound Pendulum
a compound pendulum is a physical system with a more complex structure than a simple pendulum, incorporating its mass distribution and dimensions into its oscillatory motion around a fixed axis. Understanding its dynamics involves principles of rotational mechanics and the interplay between gravitational potential energy and kinetic energy. Compound pendulums are used in various scientific and engineering applications, such as seismology for measuring earthquakes, in clocks to maintain accurate timekeeping, and in mechanical systems to study oscillatory motion dynamics.
Signatures of wave erosion in Titan’s coasts
The shorelines of Titan’s hydrocarbon seas trace flooded erosional landforms such as river valleys; however, it isunclear whether coastal erosion has subsequently altered these shorelines. Spacecraft observations and theo-retical models suggest that wind may cause waves to form on Titan’s seas, potentially driving coastal erosion,but the observational evidence of waves is indirect, and the processes affecting shoreline evolution on Titanremain unknown. No widely accepted framework exists for using shoreline morphology to quantitatively dis-cern coastal erosion mechanisms, even on Earth, where the dominant mechanisms are known. We combinelandscape evolution models with measurements of shoreline shape on Earth to characterize how differentcoastal erosion mechanisms affect shoreline morphology. Applying this framework to Titan, we find that theshorelines of Titan’s seas are most consistent with flooded landscapes that subsequently have been eroded bywaves, rather than a uniform erosional process or no coastal erosion, particularly if wave growth saturates atfetch lengths of tens of kilometers.
Reaching the age of Adolescence- Class 8
This is a presentation on understanding the age of adolescence.
Methods of grain storage Structures in India.pdf
•Post-harvestlossesaccountforabout10%oftotalfoodgrainsduetounscientificstorage,insects,rodents,micro-organismsetc.,
•Totalfoodgrainproductioninindiais311milliontonnesandstorageis145mt.InIndia,annualstoragelosseshavebeenestimated14mtworthofRs.7,000croreinwhichinsectsaloneaccountfornearlyRs.1,300crores.
•InIndiaoutofthetotalproduction,about30%ismarketablesurplus
•Remaining70%isretainedandstoredbyfarmersforconsumption,seed,feed.Hence,growerneedstoragefacilitytoholdaportionofproducetosellwhenthemarketingpriceisfavourable
•TradersandCo-operativesatmarketcentresneedstoragestructurestoholdgrainswhenthetransportfacilityisinadequate
BIRDS DIVERSITY OF SOOTEA BISWANATH ASSAM.ppt.pptx
Ahota Beel, nestled in Sootea Biswanath Assam , is celebrated for its extraordinary diversity of bird species. This wetland sanctuary supports a myriad of avian residents and migrants alike. Visitors can admire the elegant flights of migratory species such as the Northern Pintail and Eurasian Wigeon, alongside resident birds including the Asian Openbill and Pheasant-tailed Jacana. With its tranquil scenery and varied habitats, Ahota Beel offers a perfect haven for birdwatchers to appreciate and study the vibrant birdlife that thrives in this natural refuge.
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
Physics Investigatory Project on transformers. Class 12th
Physics investigatory project on transformers with required details for 12thes. with index, theory, types of transformers (with relevant images), procedure, sources of error, aim n apparatus along with bibliography🗃️📜. Please try to add your own imagination rather than just copy paste... Hope you all guys friends n juniors' like it. peace out✌🏻✌🏻
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
I am the PhD scholar of FND department, Assam down town University
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
Undergrad Physics - BSc Physics
一比一原版美国佩斯大学毕业证如何办理
原版一模一样【微信：741003700 】【美国佩斯大学毕业证成绩单】【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
【主营项目】
一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
办理美国佩斯大学毕业证【微信：741003700 】外观非常简单，由纸质材料制成，上面印有校徽、校名、毕业生姓名、专业等信息。
办理美国佩斯大学毕业证【微信：741003700 】格式相对统一，各专业都有相应的模板。通常包括以下部分：
校徽：象征着学校的荣誉和传承。
校名:学校英文全称
授予学位：本部分将注明获得的具体学位名称。
毕业生姓名：这是最重要的信息之一，标志着该证书是由特定人员获得的。
颁发日期：这是毕业正式生效的时间，也代表着毕业生学业的结束。
其他信息：根据不同的专业和学位，可能会有一些特定的信息或章节。
办理美国佩斯大学毕业证【微信：741003700 】价值很高，需要妥善保管。一般来说，应放置在安全、干燥、防潮的地方，避免长时间暴露在阳光下。如需使用，最好使用复印件而不是原件，以免丢失。
综上所述，办理美国佩斯大学毕业证【微信：741003700 】是证明身份和学历的高价值文件。外观简单庄重，格式统一，包括重要的个人信息和发布日期。对持有人来说，妥善保管是非常重要的。
Post translation modification by Suyash Garg
overview of PTM helps to the students who wants to clear their basics about it.
Rodents, Birds and locust_Pests of crops.pdf
Mole rat or Lesser bandicoot rat, Bandicotabengalensis
•Head -round and broad muzzle
•Tail -shorter than head, body
•Prefers damp areas
•Burrows with scooped soil before entrance
•Potential rat, one pair can produce more than 800 offspringsin one year
JAMES WEBB STUDY THE MASSIVE BLACK HOLE SEEDS
The pathway(s) to seeding the massive black holes (MBHs) that exist at the heart of galaxies in the present and distant Universe remains an unsolved problem. Here we categorise, describe and quantitatively discuss the formation pathways of both light and heavy seeds. We emphasise that the most recent computational models suggest that rather than a bimodal-like mass spectrum between light and heavy seeds with light at one end and heavy at the other that instead a continuum exists. Light seeds being more ubiquitous and the heavier seeds becoming less and less abundant due the rarer environmental conditions required for their formation. We therefore examine the different mechanisms that give rise to different seed mass spectrums. We show how and why the mechanisms that produce the heaviest seeds are also among the rarest events in the Universe and are hence extremely unlikely to be the seeds for the vast majority of the MBH population. We quantify, within the limits of the current large uncertainties in the seeding processes, the expected number densities of the seed mass spectrum. We argue that light seeds must be at least 103 to 105 times more numerous than heavy seeds to explain the MBH population as a whole. Based on our current understanding of the seed population this makes heavy seeds (Mseed > 103 M⊙) a significantly more likely pathway given that heavy seeds have an abundance pattern than is close to and likely in excess of 10−4 compared to light seeds. Finally, we examine the current state-of-the-art in numerical calculations and recent observations and plot a path forward for near-future advances in both domains.
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
ABSTRACT
The J'BaFofi, or "Giant Spider," is a mainly legendary arachnid by reportedly inhabiting the dense rain forests of
the Congo. As despite numerous anecdotal accounts and cultural references, the scientific validation remains more elusive.
My study aims to proper evaluate the existence of the J'BaFofi through the analysis of historical reports,indigenous
testimonies and modern exploration efforts.
Mites,Slug,Snail_Infesting agricultural crops.pdf
Order : Trombidiformes (Acarina) Class : Arachnida
Mites normally feed on the undersurface of the leaves but the symptoms are more easily seen on the uppersurface.
Tetranychids produce blotching (Spots) on the leaf-surface.
Tarsonemids and Eriophyids produce distortion (twist), puckering (Folds) or stunting (Short) of leaves.
Eriophyids produce distinct galls or blisters (fluid-filled sac in the outer layer)
Recently uploaded (20)
BIRDS DIVERSITY OF SOOTEA BISWANATH ASSAM.ppt.pptx
BIRDS DIVERSITY OF SOOTEA BISWANATH ASSAM.ppt.pptx
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
Delhi Call Girls ✓WhatsApp 9999965857 🔝Top Class Call Girl Service Available
Physics Investigatory Project on transformers. Class 12th
Physics Investigatory Project on transformers. Class 12th
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
Synopsis presentation VDR gene polymorphism and anemia (2).pptx
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
22PH503 - Astronomy and Astrophysics - Unit 2 - Spectral Classification of Stars
acanthocytes_causes_etiology_clinical sognificance-future.pptx
acanthocytes_causes_etiology_clinical sognificance-future.pptx
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
Evaluation and Identification of J'BaFofi the Giant Spider of Congo and Moke...
Aydin Reagent Bioconjugation Intro
- 1. Aydin Reagents: New Amine Conjugation – ‘Click’ chemistry Reagents Huisgen 3+2 Conjugation with Cu(I) Activated Acid Conjugation (for amine conjugation) New Di-Aldehyde Conjugation for Amines (Aydin Reagents) For amines, hydrazines and oxyamine based conjugation + Cu (I) + + Aydin Reagent Conjugate
- 2. NH2 amine Di-aldehyde (Aydin Reagent) Conjugate Aydin ‘Click’ Chemistry Stable Fast Efficient Aqueous Conditions Physiological Conditions Irreversible No Side Products + H2O New ‘Click’ Chemistry - Conjugation to amine (-NH2) containing molecules (Aliphatic Di-Aldehyde System) = Fluorophore, Ligand, Drug, Small molecule, Protein, Antibody, Lipid Carbohydrate, Nucelic Acids, Peptide, Antibody, Dye, Radiolabel, Spin label, Redox molecule, Isotope label, PET label, Nanoparticle, Polymer, Macrocycle, Metal-complex, MOF, etc…
- 3. NH2 NH-NH2 ONH2 amine oxyamine hydrazine Aydin Reagent Conjugate ‘Click’ Chemistry Conjugation Aydin Reagents are versatile - can react with 3 different groups (amine, hydrazine and oxyamine)
- 4. New ‘Click’ Chemistry (Summary) 1. Fast - within seconds to minutes in aqueous conditions 2. Stable - conjugation product is stable, irreversible 3. H2O is the side product – easy purification, no activation or leaving group 4. Does not require a catalyst 5. Superior to Huisgen 3 +2 click chemistry, which requires Cu(I) catalyst 6. Di-aldehyde coupling can be performed at room temperature in aqueous or organic solvent 7. New IP for di-aldehyde conjugation 8. Di-aldehyde can react with amine, hydrazine and oxyamine groups. one conjugation group that can react with 3 different chemistries. Easy to incorporate with existing bioconjugation molecules that contain amine, hydrazine or oxyamine groups. 9. Similar to NHS ester conjugation (succinimidyl activation of acids) to react with amines. However di-aldehyde does not require activation and does not have a side product requiring further purification. 10. Di-aldehyde fluorophores and Di-aldehyde reagents would be new suite of bio-conjugation tools. The di-aldehyde can also be used for non-biological applications (polymers, nanoparticles, etc..)