An autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. There are more than 80 types of autoimmune disorders.
It is a pathological state arising from an abnormal immune response of the body to substances and tissues that are normally present in the body.
The document provides an overview of strategic outsourcing issues from the perspective of global sourcing. It discusses trends in the marketplace, defining information technology outsourcing (ITO) and business process outsourcing (BPO). ITO and BPO are examined in more detail, including current perspectives and examples of each. Offshoring is presented as a major form of outsourcing transaction. Sourcing strategy and the sourcing spectrum are briefly outlined.
The document discusses developing customer focus. It outlines that customers are vital to any organization's success and their expectations include having questions answered, problems solved, and ideas shared in a timely manner. The goals for meeting customer expectations are to treat them well, satisfy their needs, and make them feel valued. Customers expect high quality, fair priced, clean, and safe products and services. Building good customer relationships and maintaining customer loyalty are also discussed.
Prashant Kumar is seeking a job in a progressive firm as a team player to achieve corporate goals and become a successful technical lead. He has strong communication and leadership skills as well as the ability to adapt quickly to new situations. His academic qualifications include a 79.3% in 10th grade from New Delhi Public School and a 64.8% in 12th grade from R.B.S College. He is currently pursuing a B.Tech degree from UCER Gr. Noida UP with a 60% score until the 5th semester. He was awarded Fresher Student of the year in 2012-13 and Best Attendance in 2013-14. His extracurricular activities include coordinating Electromania
The document discusses the data challenges faced by FOX Audience Network (FAN) in analyzing and utilizing their massive data stores. FAN captures 3-5 billion ad serving events daily and updates 30-50 million user profiles, training over 2,000 models weekly against terabytes of data. The data varies dramatically between their Hadoop and Greenplum systems - user data is sparse, unstructured, and unreliable while advertiser data is dense, verified business data. The tasks also differ, with user data requiring parsing and limited passes while advertiser data supports hundreds of tables, joins, views and reporting. FAN is working to improve communication between the systems using Hive and a message bus to better share all data.
The document analyzes key growth factors for the Indian real estate sector in 2014. It notes that real estate in India has been underperforming but is relying on foreign direct investment for growth. Rising household income, urbanization, economic growth, policy support, and other factors are driving increased demand for residential and commercial real estate. Foreign investment in Indian real estate totaled $22.67 billion from 2010 to 2013. The growing health, education, hospitality, and tourism sectors also provide opportunities for real estate development. Policy reforms around funding and regulations support further growth of the Indian real estate market.
How To: Mobile "Hello World" With Xamarin and Visual Studio 2013IndyMobileNetDev
This document provides information about creating cross-platform mobile applications using Xamarin and Visual Studio 2013 for iOS, Android, and Windows Phone. It discusses downloading and installing the necessary tools for each platform, creating basic projects for Hello World apps, and adding buttons and click handlers to the user interfaces. It also covers some tools for staying cross-platform like portable class libraries and shared projects. The document concludes with some tips and examples of good open source cross-platform apps to review.
This document summarizes the performance of a student managed fund from October to April. The original strategy involved creating a well-diversified portfolio across asset classes. The portfolio returned 8.51% outperforming the S&P 500's return of 10.11%. A buy and hold strategy from October to March returned 10.72% compared to the S&P 500's 7%. However, a partial strategy shift in March involving trades of leveraged ETFs led to higher trading fees and less returns than sticking to the original buy and hold approach.
The document discusses social apps on various social networking platforms. It provides details on the basic components needed for a social platform like an existing social graph and viral elements. Facebook is highlighted as the fastest growing social network and the first to create a social app platform. The anatomy of a Facebook app is explained including elements like the canvas page, left nav, and profile box. Examples of top Facebook apps are provided. Finally, the document outlines what is needed to build a social app including using a web container, API calls, and basic FBML tags.
This document discusses network-centric collaboration and the power of decentralized operations. It provides background on previous collaboration software like Lotus Notes. It then discusses how organizations are becoming more decentralized in their operations while still needing to integrate across their value chains. The document introduces Groove software as a collaboration tool that works adaptively like people, allowing for mobility, disconnected operations, and self-forming networks. It demonstrates Groove's use during Operation Iraqi Freedom to rapidly share battlefield assessments across a distributed network in real-time.
This document discusses BoxTone, a company that provides mobile user management solutions. Founded in 2005, BoxTone now manages over 500,000 mobile users for over 230 customers. The document outlines key trends driving growth in mobile usage and the importance of developing a strategy to engage internal employees and external customers through mobile applications. It describes BoxTone's solution for proactively managing mobile users to maximize productivity while reducing costs and risks.
This document discusses middleware and application integration. It begins with the author's background and defines middleware as software that connects applications. The main challenges driving integration are growing use of packaged applications, legacy systems, open B2B collaboration, and changing business processes. Middleware addresses these challenges by preserving existing systems and allowing best of breed applications to integrate. The document then categorizes middleware into data access, messaging, object transactional, and integration broker types. It explains each type and how they provide integration. The document concludes with guidance on evaluating middleware based on integration requirements and criteria like performance, scalability, and vendor viability.
The document discusses the author's long history of loyalty to Ford vehicles spanning over 30 years. It details the various Ford models the author has owned, from a Ford Pinto to multiple Ford Explorers to a current Ford Fusion hybrid. The author cites their family arguments over GM and Ford as the driving force behind their Ford loyalty. Safety and ease of maintenance were also factors, as the author enjoyed working on Ford vehicles. The document concludes by praising Ford's new EcoBoost engines and the fuel efficiency of the Ford Fusion hybrid.
Nagaraj is seeking an entry-level position in marketing and business development. He has 1 year and 9 months of experience in marketing, event management, sales, client services, and competitor analysis. He has a technical background in quality control and has worked as a Sales Officer for VST Tillers and Tractors Ltd. He has a B.E. in Automobile Engineering and is proficient in Tamil, English, Malayalam, and Telugu.
The document discusses how the media product uses and challenges conventions of real horror media. It used many generic horror conventions like gory scenes, creepy locations like asylums, and cinematography techniques like close-ups and quick cuts to build tension. However, it also challenged conventions by having the final girl be a blonde instead of the typical brunette. The media product was influenced by the horror genre and directors like James Wan but also brought its own style through a hybrid genre and strong female leads.
1. Juvenile dermatomyositis differs from adult DM in that it lacks calcinosis cutis, malignancy, and has less sex predominance and vasculitis. Adults can develop malignancy and positive anti-synthetase antibodies.
2. Two medications that can induce dermatomyositis are statins and hydroxyurea. Two features that differ DM lesions from LE are their violaceous hue and pruritus.
3. Indications for treatment of hemangiomas include obscuring vision, compromising airway, ulceration and pain, and being in a cosmetically sensitive area. The approach for starting propranolol includes testing for contraindications and slowly
Changes in newborn, pregnancy and old ageAhmed Amer
The document discusses skin changes in newborns and aging. In newborns, the key skin functions are the barrier function, eccrine sweating, and sebaceous gland secretion. Common physiological reactions in newborns include Vernix caseosa, scalp hair shedding, body hair lanugo, and superficial desquamation in the epidermis. In the dermis, peripheral cyanosis, erythema neonatorum, marbling, and harlequin color changes can occur. Skin changes in pregnancy include pigmentation, hair and nail changes, increased gland activity, connective tissue changes like striae, and vascular changes like spider angiomas. Skin aging is caused by intrinsic and extrinsic
An autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. There are more than 80 types of autoimmune disorders.
It is a pathological state arising from an abnormal immune response of the body to substances and tissues that are normally present in the body.
The document provides an overview of strategic outsourcing issues from the perspective of global sourcing. It discusses trends in the marketplace, defining information technology outsourcing (ITO) and business process outsourcing (BPO). ITO and BPO are examined in more detail, including current perspectives and examples of each. Offshoring is presented as a major form of outsourcing transaction. Sourcing strategy and the sourcing spectrum are briefly outlined.
The document discusses developing customer focus. It outlines that customers are vital to any organization's success and their expectations include having questions answered, problems solved, and ideas shared in a timely manner. The goals for meeting customer expectations are to treat them well, satisfy their needs, and make them feel valued. Customers expect high quality, fair priced, clean, and safe products and services. Building good customer relationships and maintaining customer loyalty are also discussed.
Prashant Kumar is seeking a job in a progressive firm as a team player to achieve corporate goals and become a successful technical lead. He has strong communication and leadership skills as well as the ability to adapt quickly to new situations. His academic qualifications include a 79.3% in 10th grade from New Delhi Public School and a 64.8% in 12th grade from R.B.S College. He is currently pursuing a B.Tech degree from UCER Gr. Noida UP with a 60% score until the 5th semester. He was awarded Fresher Student of the year in 2012-13 and Best Attendance in 2013-14. His extracurricular activities include coordinating Electromania
The document discusses the data challenges faced by FOX Audience Network (FAN) in analyzing and utilizing their massive data stores. FAN captures 3-5 billion ad serving events daily and updates 30-50 million user profiles, training over 2,000 models weekly against terabytes of data. The data varies dramatically between their Hadoop and Greenplum systems - user data is sparse, unstructured, and unreliable while advertiser data is dense, verified business data. The tasks also differ, with user data requiring parsing and limited passes while advertiser data supports hundreds of tables, joins, views and reporting. FAN is working to improve communication between the systems using Hive and a message bus to better share all data.
The document analyzes key growth factors for the Indian real estate sector in 2014. It notes that real estate in India has been underperforming but is relying on foreign direct investment for growth. Rising household income, urbanization, economic growth, policy support, and other factors are driving increased demand for residential and commercial real estate. Foreign investment in Indian real estate totaled $22.67 billion from 2010 to 2013. The growing health, education, hospitality, and tourism sectors also provide opportunities for real estate development. Policy reforms around funding and regulations support further growth of the Indian real estate market.
How To: Mobile "Hello World" With Xamarin and Visual Studio 2013IndyMobileNetDev
This document provides information about creating cross-platform mobile applications using Xamarin and Visual Studio 2013 for iOS, Android, and Windows Phone. It discusses downloading and installing the necessary tools for each platform, creating basic projects for Hello World apps, and adding buttons and click handlers to the user interfaces. It also covers some tools for staying cross-platform like portable class libraries and shared projects. The document concludes with some tips and examples of good open source cross-platform apps to review.
This document summarizes the performance of a student managed fund from October to April. The original strategy involved creating a well-diversified portfolio across asset classes. The portfolio returned 8.51% outperforming the S&P 500's return of 10.11%. A buy and hold strategy from October to March returned 10.72% compared to the S&P 500's 7%. However, a partial strategy shift in March involving trades of leveraged ETFs led to higher trading fees and less returns than sticking to the original buy and hold approach.
The document discusses social apps on various social networking platforms. It provides details on the basic components needed for a social platform like an existing social graph and viral elements. Facebook is highlighted as the fastest growing social network and the first to create a social app platform. The anatomy of a Facebook app is explained including elements like the canvas page, left nav, and profile box. Examples of top Facebook apps are provided. Finally, the document outlines what is needed to build a social app including using a web container, API calls, and basic FBML tags.
This document discusses network-centric collaboration and the power of decentralized operations. It provides background on previous collaboration software like Lotus Notes. It then discusses how organizations are becoming more decentralized in their operations while still needing to integrate across their value chains. The document introduces Groove software as a collaboration tool that works adaptively like people, allowing for mobility, disconnected operations, and self-forming networks. It demonstrates Groove's use during Operation Iraqi Freedom to rapidly share battlefield assessments across a distributed network in real-time.
This document discusses BoxTone, a company that provides mobile user management solutions. Founded in 2005, BoxTone now manages over 500,000 mobile users for over 230 customers. The document outlines key trends driving growth in mobile usage and the importance of developing a strategy to engage internal employees and external customers through mobile applications. It describes BoxTone's solution for proactively managing mobile users to maximize productivity while reducing costs and risks.
This document discusses middleware and application integration. It begins with the author's background and defines middleware as software that connects applications. The main challenges driving integration are growing use of packaged applications, legacy systems, open B2B collaboration, and changing business processes. Middleware addresses these challenges by preserving existing systems and allowing best of breed applications to integrate. The document then categorizes middleware into data access, messaging, object transactional, and integration broker types. It explains each type and how they provide integration. The document concludes with guidance on evaluating middleware based on integration requirements and criteria like performance, scalability, and vendor viability.
The document discusses the author's long history of loyalty to Ford vehicles spanning over 30 years. It details the various Ford models the author has owned, from a Ford Pinto to multiple Ford Explorers to a current Ford Fusion hybrid. The author cites their family arguments over GM and Ford as the driving force behind their Ford loyalty. Safety and ease of maintenance were also factors, as the author enjoyed working on Ford vehicles. The document concludes by praising Ford's new EcoBoost engines and the fuel efficiency of the Ford Fusion hybrid.
Nagaraj is seeking an entry-level position in marketing and business development. He has 1 year and 9 months of experience in marketing, event management, sales, client services, and competitor analysis. He has a technical background in quality control and has worked as a Sales Officer for VST Tillers and Tractors Ltd. He has a B.E. in Automobile Engineering and is proficient in Tamil, English, Malayalam, and Telugu.
The document discusses how the media product uses and challenges conventions of real horror media. It used many generic horror conventions like gory scenes, creepy locations like asylums, and cinematography techniques like close-ups and quick cuts to build tension. However, it also challenged conventions by having the final girl be a blonde instead of the typical brunette. The media product was influenced by the horror genre and directors like James Wan but also brought its own style through a hybrid genre and strong female leads.
1. Juvenile dermatomyositis differs from adult DM in that it lacks calcinosis cutis, malignancy, and has less sex predominance and vasculitis. Adults can develop malignancy and positive anti-synthetase antibodies.
2. Two medications that can induce dermatomyositis are statins and hydroxyurea. Two features that differ DM lesions from LE are their violaceous hue and pruritus.
3. Indications for treatment of hemangiomas include obscuring vision, compromising airway, ulceration and pain, and being in a cosmetically sensitive area. The approach for starting propranolol includes testing for contraindications and slowly
Changes in newborn, pregnancy and old ageAhmed Amer
The document discusses skin changes in newborns and aging. In newborns, the key skin functions are the barrier function, eccrine sweating, and sebaceous gland secretion. Common physiological reactions in newborns include Vernix caseosa, scalp hair shedding, body hair lanugo, and superficial desquamation in the epidermis. In the dermis, peripheral cyanosis, erythema neonatorum, marbling, and harlequin color changes can occur. Skin changes in pregnancy include pigmentation, hair and nail changes, increased gland activity, connective tissue changes like striae, and vascular changes like spider angiomas. Skin aging is caused by intrinsic and extrinsic
This document summarizes different blood components that can be transfused, including whole blood, fresh frozen plasma, cryoprecipitate, packed red blood cells, platelet preparations, and immunoglobulins. It provides details on what each component contains, how it is prepared, storage times, indications for transfusion, and contraindications. The document also reviews blood type compatibility and lists several indications for plasma pharesis procedures.
Basic immunology from the dermatologic point of viewAhmed Amer
The document discusses the immune system, focusing on innate immunity and the skin's role in protection. It describes how the skin provides a mechanical barrier and uses the immune system for protection through skin-associated lymphoid tissues. The innate immune system includes physical barriers and pattern recognition receptors that recognize pathogens. Toll-like receptors are a type of pattern recognition receptor that recognize pathogen-associated molecular patterns and trigger cytokine production and adaptive immunity.
Basic immunology from the dermatologic point of view (2)Ahmed Amer
The document discusses the immune system, with a focus on the skin and its role in immunity. It describes how the skin acts as a physical barrier and uses the immune system for protection through skin-associated lymphoid tissues. Both innate and adaptive immunity operate in the skin. Innate immunity provides an immediate response and involves pattern recognition receptors on cells that recognize pathogen-associated molecular patterns. Adaptive immunity develops over days and provides pathogen-specific protection.
Barrier function & biomechanical properties of the skin Ahmed Amer
This document summarizes the structure and function of the skin barrier. It describes the epidermis, stratum corneum, dermis, and basement membrane zone. The stratum corneum consists of corneocytes bound by lipid mortar, forming the skin's barrier against water loss and insults. Defects in corneocytes or lipids cause skin diseases. The dermis contains collagen, elastin, and glycosaminoglycans that provide mechanical strength, elasticity, and resistance to compression. Inherited disorders impact these structures, altering the skin's biomechanical properties.
This document discusses antibiotics, how they work selectively against bacteria, and mechanisms of bacterial resistance. It covers several classes of antibiotics including beta-lactams, aminoglycosides, macrolides, chloramphenicol, vancomycin, sulfonamides, quinolones and more. It also discusses factors that promote antibiotic resistance, appropriate use of antibiotics and optimizing treatment based on culture and sensitivity testing.
Anatomy & physiology of sweat glands, sebaceousAhmed Amer
1. The document describes the anatomy and physiology of sweat glands, sebaceous glands, hair, and nails. It discusses the structure, development, innervation, function, and disorders of eccrine and apocrine sweat glands.
2. Sebaceous glands are described in relation to their sites of occurrence, development linked to androgen levels, and role in secreting sebum.
3. The stages of the hair follicle from infundibulum to bulb and the cycle of hair growth and shedding are outlined. The structure and pigmentation of the hair shaft is also covered.
4. Nail anatomy includes the nail plate, proximal nail fold, nail bed, nail
All about genes oncogenes mutations-cloning-gene therapyAhmed Amer
1) DNA contains the genetic code and is located in chromosomes within the nucleus. DNA is transcribed into RNA and translated into proteins, which allows genes to be expressed.
2) Mutations in genes can be caused by errors in DNA replication or exposure to mutagens and can have neutral, harmful, or beneficial effects depending on where they occur. Mutations in proto-oncogenes can transform them into oncogenes and promote cancer development.
3) Cloning techniques allow for the duplication of DNA, whole organisms, or embryonic stem cells for research and potential therapies. Gene cloning is used to study and modify genes, while reproductive and therapeutic cloning are more controversial due to ethical concerns.
This document discusses biologic agents used to treat psoriasis. It defines biologics as proteins extracted from tissues or synthesized through recombinant DNA techniques that mimic or block naturally occurring proteins. Early biologics included insulin, hematopoietic growth factors, and monoclonal antibodies used to prevent transplant rejection. Current biologics for psoriasis include TNF-α inhibitors (etanercept, adalimumab, infliximab), which bind and neutralize tumor necrosis factor; and ustekinumab, which targets the p40 subunit of interleukin-12 and -23. The document provides details on the mechanisms, dosing, and side effects of these biologic therapies.