1) The AURELIA trial evaluated bevacizumab combined with chemotherapy versus chemotherapy alone for platinum-resistant recurrent ovarian cancer.
2) The trial found that progression-free survival was significantly longer in the bevacizumab combination group compared to the chemotherapy alone group (median 6.7 months vs 3.4 months).
3) Rates of objective response were also significantly higher in the bevacizumab combination group compared to chemotherapy alone (30.9% vs 12.6%).
Report Back from San Antonio Breast Cancer Symposium (SABCS 2022)bkling
Curious about the latest developments in Early-Stage Breast Cancer and Metastatic Breast Cancer Research? Join us as Dr. Anne Blaes, the Division Director of Hematology/Oncology/Transplantation and Professor in Hematology/Oncology at the University of Minnesota, breaks down the most recent developments released at the annual San Antonio Breast Cancer Symposium regarding early-stage and metastatic breast cancer research.
Report Back from San Antonio Breast Cancer Symposium (SABCS 2022)bkling
Curious about the latest developments in Early-Stage Breast Cancer and Metastatic Breast Cancer Research? Join us as Dr. Anne Blaes, the Division Director of Hematology/Oncology/Transplantation and Professor in Hematology/Oncology at the University of Minnesota, breaks down the most recent developments released at the annual San Antonio Breast Cancer Symposium regarding early-stage and metastatic breast cancer research.
Overview about evolution of the term Oligometastases,the paradigm and various states of oligometastases,treat options ,clinical trials and relevance in current clinical practice
Randomized comparison of adjuvant aromatase inhibitor exemestane (E) plus ovarian function suppression (OFS) vs tamoxifen (T) plus OFS in premenopausal women with hormone receptor positive (HR+) early breast cancer (BC):
Overview about evolution of the term Oligometastases,the paradigm and various states of oligometastases,treat options ,clinical trials and relevance in current clinical practice
Randomized comparison of adjuvant aromatase inhibitor exemestane (E) plus ovarian function suppression (OFS) vs tamoxifen (T) plus OFS in premenopausal women with hormone receptor positive (HR+) early breast cancer (BC):
PrEP and My Patients: Guidance for LGBT Community–Based Primary Care Provider...Clinical Care Options
Expert faculty Jared Baeten, MD, PhD; Susan Buchbinder, MD; Connie L. Celum, MD, MPH; and Albert Liu, MD, MPH review emerging data on pre-exposure prophylaxis and antiretroviral therapy as prevention and discuss implications for community providers.
In Silico Prescription of Anticancer Drugs Reveals Targeting OpportunitiesNuria Lopez-Bigas
Large efforts dedicated to sequence thousands of tumor genome/exomes are expected to lead to significant improvements of precision cancer medicine. However, high inter-tumor heterogeneity is a major obstacle in the road to develop an arsenal of targeted cancer drugs to treat most cancer patients. Therefore, it is critical to understand the current scope of anti-cancer targeted drugs for different tumor types in order to use them with the highest efficacy, and to define priorities for the development of new ones. We have developed a novel methodology to interpret the genomes of a cohort of tumor samples and to assess their therapeutic opportunities. Starting with somatic mutations detected across the cohort, the methodology identifies the driver genes, highlights those that dominate the clonal landscape of the tumors and determines their mode of action. It then does an in-silico prescription of approved and candidate targeted drugs to each patient in the cohort. The application of this approach to a cohort of 6795 cancer samples of 28 different tumor types showed that the fraction of patients that could benefit from prescribed FDA-approved drugs is strikingly small. Nevertheless, it improves significantly if repurposing opportunities are taken into consideration, with large differences between tumor types. In addition, we identify 80 therapeutically unexploited cancer genes, tightly bound by pre-clinical small molecules or potentially suitable for molecule binding. The resource created with this analysis is also intended to provide interpretation of newly sequenced cancer genomes and to design pan-cancer and tumor type specific sequencing panels for efficient early cancer detection and clinical insight.
More details at http://www.intogen.org
Identification of cancer drivers across tumor typesNuria Lopez-Bigas
Thousands of tumor genomes/exomes are being sequenced as part of the International Cancer Genome Consortium (ICGC), The Cancer Genome Atlas (TCGA) and other initiatives. This opens the possibility to have, for the first time, a comprehensive picture of mutations, genes and pathways involved in the cancer phenotype across tumor types. We have developed computational methods able to identify signals of positive selection in the pattern of tumor somatic mutations, which point to genes and pathways directly involved in the development of the tumors. We have applied these approaches to 3025 tumors from 12 different cancer types of the TCGA Pan-Cancer project, identifying 291 high-confidence cancer driver genes acting on those tumors (Tamborero et al 2013). We have also developed IntOGen-mutations (http://www.intogen.org/mutations), a novel web platform for cancer genomes interpretations, which analyses not only TCGA pan-cancer data but all mutation data from ICGC and other initiatives. The resource allows users to identify driver mutations, genes and pathways acting on more than 6000 tumors originated in 17 different cancer sites and to analyze newly sequence tumor genomes. Among the novel cancer drivers identified there are chromatin regulatory factors and splicing factors, which are emerging as important genes in cancer development and are regarded as interesting candidates for novel targets for cancer treatment. In my talk I will summarize all these recent findings.
More info: http://bg.upf.edu/blog/2013/10/my-slides-on-identification-of-cancer-drivers-across-tumor-types/
Dr. Paul Sabbatini: Recurrent Ovarian Cancer: Now What? (SHARE Program)bkling
On May 22, 2013, SHARE presented "Recurrent Ovarian Cancer: Now What?" The program featured Dr. Ginger Gardner and Dr. Paul Sabbatini of Memorial Sloan-Kettering Cancer Center discussing treatment strategies, as well as new approaches and agents, for managing an ovarian cancer recurrence. Listen to the audio here http://www.sharecancersupport.org/sabbatini.
The information in this presentation is not intended to be a substitute for professional medical advice, diagnosis or treatment.
Presentación realizada por la Dra. Pilar Escudero del HCU Lozano Blesa, en el marco de la I Jornada de actualización e innovación en Oncología que tuvo lugar en el CIBA en enero de 2015.
Circulating Tumor Cells (CTC) and pathological Complete Response (pCR) are strong independent prognostic factors in Inflammatory Breast Cancer (IBC) in a pooled analysis of two multicentre phase II trials (BEVERLY 1 & 2) of neoadjuvant chemotherapy combined with bevacizumab
Pr Olivier Glehen (Lyon - France) presents HIPEC in treatment for colorectal and gastric carcinomatosis. La CHIP dans le traitement des carcinoses péritonéales d'origine colorectale et gastrique.
Cette présentation faite le 27 Avril 2017 à l'Hôpital Saint Joseph organisée par le Dr Vincent de Parades fait le point sur les nouvelles approches multidisciplinaires dans la prise en charge des cancers colorectaux en insistant sur la prise en charge de la maladie métastatique hépatique et de la carcinome péritonéale pour terminer sur les nouvelles approches par immunothérapie. Cette EPU a connu un large succès d'audience avec plus de 60 participants. Merci à toutes et tous.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
1. AURELIA: A randomized phase III trial evaluating
bevacizumab combined with chemotherapy for
platinum-resistant recurrent ovarian cancer
Eric Pujade-Lauraine1, Felix Hilpert2, Béatrice Weber3, Alexander Reuss4, Andres
Poveda5, Gunnar Kristensen6, Roberto Sorio7, Ignace Vergote8, Petronella Witteveen9,
Aristotelis Bamias10, Deolinda Pereira11, Pauline Wimberger12, Ana Oaknin13, Mansoor
Raza Mirza14, Philippe Follana15, David Bollag16, Isabelle Ray-Coquard17,
on behalf of the ENGOT‒GCIG investigators
1GINECO and Université Paris Descartes, Paris, France; 2AGO and Klinik für Gynäkologie und Geburtshilfe, Kiel,
Germany; 3GINECO and Centre Alexis Vautrin, Vandoeuvre-les-Nancy, France; 4AGO and Coordinating Center for
Clinical Trials, Marburg, Germany; 5GEICO and Instituto Valenciano de Oncologia, Valencia, Spain; 6NSGO and
Norwegian Radium Hospital, Oslo, Norway; 7MITO and Centro di Riferimento Oncologico-IRCCS, Aviano, Italy;
8BGOG and University Hospital Leuven, Leuven, Belgium; 9DGOG and University Medical Center Utrecht, Utrecht,
The Netherlands; 10HECOG and University of Athens, Athens, Greece; 11GINECO and IPO-Porto, Porto, Portugal;
12AGO and Department of Gynecology and Obstetrics, University of Duisburg-Essen, Essen, Germany; 13GEICO and
Vall d’Hebron University Hospital, Barcelona, Spain; 14NSGO-Nordic Society of Gynaecological Oncology,
Copenhagen, Denmark; 15GINECO and Department of Medical Oncology, Centre Antoine-Lacassagne, Nice, France;
16F. Hoffmann-La Roche, Basel, Switzerland; 17GINECO and Centre Léon Bérard, Lyon, France
2. VEGF = vascular endothelial growth factor
1. Burger NEJM 2011; 2. Perren NEJM 2011; 3. Aghajanian JCO 2012
Background
• Ovarian cancer (OC) is a highly VEGF-driven disease
• Bevacizumab (BEV) significantly improves progression-free survival
(PFS) when combined with chemotherapy and continued as a single
agent in the:
Front-line setting (GOG-0218, ICON7)1,2
Platinum-sensitive recurrent setting (OCEANS)3
3. PLD = pegylated liposomal doxorubicin. GI = gastrointestinal.
1. Burger JCO 2007; 2. Cannistra JCO 2007
Platinum-resistant OC: A high unmet medical need
• At first relapse, 25% of patients have platinum-resistant OC; almost
all patients with recurrent OC will ultimately develop platinum
resistance
Single-agent therapy (eg weekly paclitaxel, PLD, or topotecan)
is standard
Combination regimens have failed to improve efficacy vs
single-agent chemotherapy
Median overall survival is typically <12 months
• BEV has demonstrated single-agent activity in this setting1,2
Concern about GI perforation in one study2
• AURELIA is the first randomized trial to evaluate the addition of BEV
to chemotherapy in platinum-resistant OC
4. PD = progressive disease
aEpithelial ovarian, primary peritoneal, or fallopian tube cancer; bOr 10 mg/kg q2w;
c15 mg/kg q3w, permitted on clear evidence of progression
AURELIA trial design
Stratification factors:
• Chemotherapy selected
• Prior anti-angiogenic therapy
• Treatment-free interval
(<3 vs 3‒6 months from previous
platinum to subsequent PD)
Platinum-resistant OCa
• ≤2 prior anticancer
regimens
• No history of bowel
obstruction/abdominal
fistula, or clinical/
radiological evidence of
rectosigmoid involvement
Treat to
PD/toxicity
Treat to
PD/toxicity
Investigator’s
choice
(without BEV)
Optional BEV
monotherapyc
BEV 15 mg/kg q3wb
+ chemotherapy
Chemotherapy
R
1:1
Chemotherapy options (investigator’s choice):
• Paclitaxel 80 mg/m2 days 1, 8, 15, & 22 q4w
• Topotecan 4 mg/m2 days 1, 8, & 15 q4w
(or 1.25 mg/m2, days 1–5 q3w)
• PLD 40 mg/m2 day 1 q4w
5. Statistical design
Primary objective: To compare PFS with chemotherapy (CT) alone vs
BEV + CT according to RECIST v1.0
Secondary objectives: To compare
• Objective response rate (ORR) according to RECIST v1.0 and/or
GCIG CA-125 criteria
• Overall survival
• Quality of life
• Safety and tolerability
Statistical assumptions
• HR of 0.7 (median PFS 4.0 → 5.7 months with BEV)
• 80% power for 2-sided log-rank test at α=0.05
Primary analysis: PFS events in 301 of 361 patients
• Data cut-off: November 14, 2011
11. HFS = hand-foot syndrome
aPreferred terms. bIncludes abdominal pain upper
Additional grade ≥3 adverse eventsa in ≥2% of
patients in either arm
0
2
4
6
8
10
12
14
16
18
CT (n=181)
BEV + CT (n=179)
Patients(%)
≈≈
≈
≈
12. 1 cycle = 4 weeks except for q3w (day 1–5) topotecan
Higher chemotherapy exposure in the BEV + CT
arm than in the CT arm
0
10
20
30
40
50
60
70
80
90
100
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18
CT (CT arm) (n=181)
CT (BEV + CT arm) (n=179)
Patients(%)
Cycle number
13. 0
10
20
30
40
50
60
70
80
90
100
1 2 3 4 5 6 7
CT BEV + CT
aIncidence is based on the No. at risk receiving PLD in the respective cycle
Vertical bars represent 95% Pearson‒Clopper confidence intervals
Cycles with <10 patients in each arm not shown
Similar time course of cumulative hand-foot
syndrome in the two armsa
Patients(%)
Cycle numberNo. at risk
CT 63 59 36 31 23 18 9
BEV + CT 62 61 48 41 30 23 10
Grade ≥2 hand-foot syndrome by cycle
(PLD cohort)
14. aIncidence is based on the No. at risk receiving paclitaxel in the respective cycle
Vertical bars represent 95% Pearson‒Clopper confidence intervals
Cycles with <10 patients in each arm not shown
Similar time course of cumulative neuropathy
in the two armsa
Patients(%)
Grade ≥2 peripheral sensory neuropathy by cycle
(paclitaxel cohort)
Cycle numberNo. at risk
CT 55 54 43 35 24 19 8 6 2
BEV + CT 60 58 53 47 41 34 20 16 11
0
10
20
30
40
50
60
70
80
90
100
1 2 3 4 5 6 7 8 9
CT BEV + CT
15. Summary
• The primary objective was met
PFS HR 0.48 (p<0.001) in favor of BEV combination therapy vs
single-agent CT
Median PFS: 6.7 vs 3.4 months, respectively
• Significant improvement in ORR
30.9% vs 12.6%, respectively (p=0.001) by RECIST and/or
CA-125
• BEV safety profile consistent with previous experience
Patients at high risk of GI perforation were excluded from
the study
• Overall survival data expected in 2013
16. Conclusions
• AURELIA is the first randomized phase III trial in platinum-resistant
OC to demonstrate:
Benefit with biologic therapy
Benefit with a combination regimen versus monotherapy
Bevacizumab combined with chemotherapy
should be considered a new standard option
in platinum-resistant ovarian cancer
17. E Pujade-Lauraine
I Ray-Coquard
B Weber
D Berton-Rigaud
P Follana
F Selle
M Fabbro
A Lortholary
F Joly
B Levaché
A Lesoin
A Floquet
C Lemaignan
L Gladieff
J Salvat
N Dohollou
JF Geay
MA Mouret-Reynier
J Meunier
D Lebrun-Jezekova
Acknowledgments
The 361 patients and their families, and …
GINECO AGO-OVAR GEICO NSGO MITO BGOG DGOG HECOG
F Hilpert
P Wimberger
P Harter
J Sehouli
R Kreienberg
B Gerber
H-J Lueck
C Uleer
T Fehm
L Hanker
A Burges
J Kosse
M Thill
G Gebauer
M Beckmann
W Meier
JP Scharf
C Uleer
T Fehm
L Hanker
J Kosse
G Kristensen
M-R Mirza
P Rosenberg
K Boman
G-B Nyvang
H Havsteen
B Tholander
I Baasland
M Anttila
N Keldsen
A Pasic
Z Vranjes
R Sorio
F Raspaglisi
P-P Benedetti
E Breda
A Savarese
L Frigerio
A Poveda
A Oaknin
M-J Rubio
E Ortega
J-A Arranz
I Bover
A Herrero
A Santaballa
I Diaz
A de Juan
A Gonzalez
Y Garcia
E Garcia
B Ojeda
I Vergote
P Vuylsteke
V D'Hondt
M Huizing
A Ayhan
E Buyukunal
O Ozyilkan
H Onat
E Witteween
G-J Creemers
HJ Bloemendal
M Los
M De Jong
Roche
Legal sponsor
D Bollag
G Hales, R Sheik
A Chlistalla
A Bamias
F Zagouri
D Pereira
F Vaz Parexel
Data & Safety Management
Medical Monitoring
Medical writing: J Kelly
IDMC JB Vermorken (Chair)
V Gebski
M Friedlander
QoL committee
M Stockler, L Wenzel, M King
E Pujade-Lauraine, F Hilpert,
C Lee, statisticians
GINECO
GCIG Leading Group
E Pujade-Lauraine (PI)
N Le Fur, B Votan
Statistics
GCIG: A Reuss
Roche: U Freudensprung
Parexel: B Piske
Editor's Notes
Tables 2.1.1, 2.2, 2.3
Tables 5.2.1.3.1, 5.2.1.3.3, 5.2.1.3.4
Table 7.4.1.13.2.1 and 3.3.1.3
Tables 3.2.1 and 3.3.1.3
Three additional cases of grade 2-5 hand-foot syndrome, all in the paclitaxel cohort:Pt 1655470002 AE start 06JUL2010, end 13JUL2010 Bevacizumab 09FEB2010 until 20JUL2010 (7 days after AE end)Paclitaxel 09FEB2010 until 27JUL2010 (14 days after AE end) Pt 1668880003 AE start 25MAY2010 , end 16JUL2010 Bevacizumab 02FEB2010 until 12APR2011 (270 days after AE end)Paclitaxel 02FEB2010 until 18MAY2010 (59 days before AE end)Pt 1676870001 AE start 27MAY2011, ongoingPaclitaxel 24FEB2011 until 04AUG2011