- Mickey and Mallory Knox are lovers who come from abusive backgrounds and go on a killing spree after murdering Mallory's parents.
- They are eventually caught and imprisoned but escape during a prison riot sparked by a TV interview with Mickey.
- The film Natural Born Killers was very controversial for its graphic violence and some claimed it inspired real-life murder cases, though there is no definitive evidence it directly caused violence.
- While the film was debated as having a possible influence on unstable individuals, most viewers did not commit acts of violence after watching it.