The midbrain, or mesencephalon (plural: mesencephala or mesencephalons), is the most rostral part of the brainstem and sits above the pons and is adjoined rostrally to the thalamus. During development, the midbrain forms from the middle of three vesicles that arise from the neural tube.
When viewed in cross-section, the midbrain can be divided into three portions:
tectum (posterior)
tegmentum
cerebral peduncles (anterior)
This document discusses acute scrotum imaging and provides information on various etiologies of acute scrotal pain including ischemia, infection, trauma, inflammation, hernia, and acute on chronic events. It describes ultrasound findings for conditions like testicular torsion, epididymitis, orchitis, hydrocele, hematocele, and Fournier's gangrene. Key points are made about Doppler ultrasound findings in torsion and the importance of prompt evaluation and treatment of acute scrotum to preserve testicular viability. Anatomy of the scrotum and imaging appearances of various acute pathologies are depicted through multiple ultrasound images.
This document provides an overview of arthritis, including its classification, features of different types of arthritis like rheumatoid arthritis and juvenile idiopathic arthritis, and their clinical presentation, pathogenesis, diagnosis and treatment. Rheumatoid arthritis most commonly affects women aged 35-50 and can be diagnosed based on criteria involving joint swelling in at least one joint, morning stiffness for over one hour, and positive rheumatoid factor or anti-CCP antibodies. Juvenile idiopathic arthritis can affect children under 16 and presents as oligoarticular or polyarticular arthritis for over six weeks, with radiographic findings including joint space narrowing and erosions.
This document provides goals and objectives for a training on evaluating and treating stroke patients in the pre-hospital setting. It reviews relevant neuroanatomy, stroke pathophysiology, risk factors, clinical assessment tools like NIHSS and LAMS scoring. It discusses distinguishing between ischemic and hemorrhagic stroke as well as common stroke mimics. The training emphasizes the importance of the pre-hospital evaluation and communicating findings to the hospital to expedite diagnosis and treatment. A case study demonstrates applying these clinical skills to assess a patient and consider differential diagnoses.
This document discusses arterial aneurysms and arteriovenous malformations (AVMs). It defines aneurysms as abnormal focal dilations of vessels over 50% in diameter from adjacent vessels. The main danger of aneurysms is rupture leading to uncontrolled hemorrhage. Aneurysms are classified based on structure, morphology, and anatomy. Abdominal aortic aneurysms are the most common type and their risk of rupture increases with size. Treatment depends on symptoms, size, location and complications. AVMs are direct connections between arteries and veins bypassing capillaries, which can cause hemorrhage, ischemia, and increased intracranial pressure. Investigation involves imaging modalities and management includes surgical resection or embolization.
This document provides an overview of dilated cardiomyopathy. It begins with an introduction defining cardiomyopathies and dilated cardiomyopathy. It then covers the classification, etiology, pathogenesis, clinical features, investigations, and treatment of dilated cardiomyopathy. The main points are that dilated cardiomyopathy involves left ventricular dilation and decreased systolic function, it has a diverse etiology including genetic factors, and treatment involves medications and devices to support heart function.
This document provides guidance on performing a comprehensive physical examination of a swelling. Key points include inspecting the swelling's location, number, shape, size, surface features, pulsations, movements, and consistency before performing palpation. Palpation involves assessing temperature, tenderness, size, surface, consistency, and performing special tests like fluctuation, transillumination, cough impulse, and reducibility to determine the nature of the swelling. A systematic approach beginning with inspection and proceeding to focused palpation can help arrive at an accurate diagnosis of the cause of the swelling.
General physical examination of the respiratory systemVijayaKumar392
This document outlines the steps for a general physical examination of the respiratory system. It describes examining the patient's general appearance, vital signs, posture, nutrition, skin, eyes, neck, chest, hands, nails, lymph nodes and feet. Specific signs of conditions like tuberculosis, clubbing and cyanosis are highlighted. Breath sounds, respiratory rate and patterns are assessed. The pulse, blood pressure, JVP and oxygen saturation are evaluated. The nasal cavity, sinuses and oral cavity are examined. Other body systems are also assessed to identify related conditions. References for further information are provided.
The midbrain, or mesencephalon (plural: mesencephala or mesencephalons), is the most rostral part of the brainstem and sits above the pons and is adjoined rostrally to the thalamus. During development, the midbrain forms from the middle of three vesicles that arise from the neural tube.
When viewed in cross-section, the midbrain can be divided into three portions:
tectum (posterior)
tegmentum
cerebral peduncles (anterior)
This document discusses acute scrotum imaging and provides information on various etiologies of acute scrotal pain including ischemia, infection, trauma, inflammation, hernia, and acute on chronic events. It describes ultrasound findings for conditions like testicular torsion, epididymitis, orchitis, hydrocele, hematocele, and Fournier's gangrene. Key points are made about Doppler ultrasound findings in torsion and the importance of prompt evaluation and treatment of acute scrotum to preserve testicular viability. Anatomy of the scrotum and imaging appearances of various acute pathologies are depicted through multiple ultrasound images.
This document provides an overview of arthritis, including its classification, features of different types of arthritis like rheumatoid arthritis and juvenile idiopathic arthritis, and their clinical presentation, pathogenesis, diagnosis and treatment. Rheumatoid arthritis most commonly affects women aged 35-50 and can be diagnosed based on criteria involving joint swelling in at least one joint, morning stiffness for over one hour, and positive rheumatoid factor or anti-CCP antibodies. Juvenile idiopathic arthritis can affect children under 16 and presents as oligoarticular or polyarticular arthritis for over six weeks, with radiographic findings including joint space narrowing and erosions.
This document provides goals and objectives for a training on evaluating and treating stroke patients in the pre-hospital setting. It reviews relevant neuroanatomy, stroke pathophysiology, risk factors, clinical assessment tools like NIHSS and LAMS scoring. It discusses distinguishing between ischemic and hemorrhagic stroke as well as common stroke mimics. The training emphasizes the importance of the pre-hospital evaluation and communicating findings to the hospital to expedite diagnosis and treatment. A case study demonstrates applying these clinical skills to assess a patient and consider differential diagnoses.
This document discusses arterial aneurysms and arteriovenous malformations (AVMs). It defines aneurysms as abnormal focal dilations of vessels over 50% in diameter from adjacent vessels. The main danger of aneurysms is rupture leading to uncontrolled hemorrhage. Aneurysms are classified based on structure, morphology, and anatomy. Abdominal aortic aneurysms are the most common type and their risk of rupture increases with size. Treatment depends on symptoms, size, location and complications. AVMs are direct connections between arteries and veins bypassing capillaries, which can cause hemorrhage, ischemia, and increased intracranial pressure. Investigation involves imaging modalities and management includes surgical resection or embolization.
This document provides an overview of dilated cardiomyopathy. It begins with an introduction defining cardiomyopathies and dilated cardiomyopathy. It then covers the classification, etiology, pathogenesis, clinical features, investigations, and treatment of dilated cardiomyopathy. The main points are that dilated cardiomyopathy involves left ventricular dilation and decreased systolic function, it has a diverse etiology including genetic factors, and treatment involves medications and devices to support heart function.
This document provides guidance on performing a comprehensive physical examination of a swelling. Key points include inspecting the swelling's location, number, shape, size, surface features, pulsations, movements, and consistency before performing palpation. Palpation involves assessing temperature, tenderness, size, surface, consistency, and performing special tests like fluctuation, transillumination, cough impulse, and reducibility to determine the nature of the swelling. A systematic approach beginning with inspection and proceeding to focused palpation can help arrive at an accurate diagnosis of the cause of the swelling.
General physical examination of the respiratory systemVijayaKumar392
This document outlines the steps for a general physical examination of the respiratory system. It describes examining the patient's general appearance, vital signs, posture, nutrition, skin, eyes, neck, chest, hands, nails, lymph nodes and feet. Specific signs of conditions like tuberculosis, clubbing and cyanosis are highlighted. Breath sounds, respiratory rate and patterns are assessed. The pulse, blood pressure, JVP and oxygen saturation are evaluated. The nasal cavity, sinuses and oral cavity are examined. Other body systems are also assessed to identify related conditions. References for further information are provided.
This document provides an overview of oesophageal anatomy, staging, and the diagnostic workup for oesophageal cancers. It describes the gross anatomy and course of the oesophagus, its arterial and venous blood supply, lymphatic drainage, and histology. Risk factors for oesophageal cancer are smoking, alcohol, and diet. Common symptoms are dysphagia and weight loss. The diagnostic workup includes imaging like barium swallow and CT scan, as well as endoscopy with biopsy. Staging is an important part of evaluating oesophageal cancers.
This document provides an overview of evaluating and managing a breast lump. It discusses the anatomy of the breast and describes the triple assessment approach including clinical examination, imaging studies, and biopsy. Common benign and malignant breast conditions are outlined. Fine needle aspiration, core needle biopsy, and excisional biopsy techniques are also summarized. The document reviews breast cancer staging and provides examples of evaluating specific breast lumps.
3er Curso Latino Americano de Cicatrización Avanzada en Heridas (II)Karen Pulido
This document discusses wound diagnosis and treatment by etiology, focusing on arterial and venous wounds. It provides 3 key points:
1. Arterial wounds are caused by ischemia due to macrovascular or microvascular disease. They typically occur on the extremities and are evaluated using pulses, capillary refill time, ABI, and other vascular tests. Treatment involves revascularization or wound care to address ischemia.
2. Venous wounds account for about 70% of lower extremity wounds and are caused by venous insufficiency and hypertension. They usually occur in the gaiter area. Risk factors include DVT history, surgery, prolonged standing, and obesity.
3. Both arterial and venous wounds are evaluated based
Ascaris lumbricoides is a large roundworm that infects the small intestine and is one of the most common parasitic infections in humans. It is transmitted through ingestion of Ascaris eggs from contaminated food, water, or soil. The life cycle involves development of larvae in soil followed by human infection through ingestion. Larvae hatch in the intestines and migrate through the lungs before returning to the intestines where they mature into adult worms. Infection may cause abdominal pain, vomiting, and respiratory symptoms. Diagnosis is usually made by examining a stool sample under a microscope. Treatment involves anthelmintic drugs and prevention focuses on handwashing and sanitation.
The thyroid gland is a butterfly-shaped endocrine gland located in the neck. It regulates metabolism and plays an important role in calcium homeostasis. The gland has two lobes joined by an isthmus and is located anterior to the trachea. It receives blood supply from the superior, middle, and inferior thyroid arteries and drains into internal jugular veins. The recurrent laryngeal nerves are at risk of injury during thyroid surgery as they pass back into the larynx.
This document discusses subarachnoid hemorrhage (SAH), which occurs when there is bleeding into the space between the brain and the thin tissues that cover the brain. The most common cause of SAH is the rupture of an intracranial aneurysm, which affects around 25,000-30,000 people in the US each year. The initial mortality rate is around 45% and over half of survivors are left with major neurological deficits. Diagnosis involves CT scans, lumbar puncture, and angiography. Treatment focuses on surgical clipping or coiling of the aneurysm as well as managing complications like vasospasm, hydrocephalus, and rebleeding through medical therapy.
Closed heart surgeries are performed without opening the heart or using a heart-lung bypass machine. They can be used to treat conditions like mitral stenosis, aortic stenosis, pulmonary embolisms, and some congenital heart defects. Rehabilitation after closed heart surgery focuses on gradually increasing a patient's mobility, strength, and endurance through exercises while avoiding complications. The goals are for patients to improve their functional capacity, quality of life, and reduce risks of issues like restenosis.
This document discusses hydrocephalus, including:
1) It defines hydrocephalus as an increased volume of cerebrospinal fluid in the ventricles due to overproduction or impaired absorption, causing increased pressure in the skull.
2) There are two main types - communicating/non-obstructive which involves overproduction or underabsorption of CSF, and non-communicating/obstructive which involves obstruction of CSF flow.
3) Clinical features vary depending on age but include increasing head size, irritability, vomiting, and signs of increased intracranial pressure like headache.
4) Treatment involves reducing CSF production medically or surgically placing a shunt to divert CSF out of
Acute scrotal pain requires rapid evaluation and treatment as certain conditions like testicular torsion are reversible if treated quickly but can lead to morbidity if not. The main causes are epididymitis, testicular torsion, and strangulated hernias. Physical exam focuses on scrotal swelling, tenderness, and cremasteric reflex to determine if surgical exploration is needed. Doppler ultrasound is usually the first imaging test to diagnose conditions like testicular torsion. Prompt surgical detorsion within 6 hours can save the testicle from infarction. Antibiotics are used to treat epididymitis while minor trauma may only require ice and analgesics. Complications include gangrene, abscess, infertility if not treated
This document provides information about several medical conditions. It begins by defining diabetes as an increased concentration of glucose in the blood and lists its main symptoms. It then discusses the history and facts about diabetes. The document also discusses cancer, defining it as uncontrolled growth and spread of abnormal cells. It lists the most common cancer types and their treatability. The document continues discussing allergies, arthritis, renal failure, asthma, and cardiovascular disease, defining each condition and providing additional details.
imaging of scrotum [Repaired] [Repaired].pptxdypradio
The scrotum contains the testes and epididymides. On ultrasound, the normal anatomy includes the oval testes with homogeneous echotexture and color flow. Potential pathological findings include infections like epididymitis, tumors such as seminomas which appear hypoechoic and well-defined, and traumatic injuries or torsion which may demonstrate absent flow. Malignancies require evaluation for metastases while infections require treatment with antibiotics. Imaging guides diagnosis and management of scrotal pathologies.
Varicose veins are dilated, tortuous subcutaneous veins caused by valvular incompetence. They develop due to primary or secondary valve failure, allowing blood to pool in the legs. Conservative treatments include compression stockings and lifestyle changes. Surgical options for varicose veins include traditional stripping and ligation, or minimally invasive procedures like endovenous laser ablation, radiofrequency ablation, and ultrasound-guided foam sclerotherapy which destroy veins through ablation or injection of sclerosing agents. Recurrence rates are lower with minimally invasive techniques. Duplex ultrasound is the gold standard for diagnosing and mapping varicose veins.
This document provides an overview of amputations, including:
- Indications for amputations include poor circulation, injury, infection, and tumors. The most common indication is poor circulation from conditions like diabetes or peripheral artery disease.
- Types of amputations include closed amputations where flaps are closed primarily and open amputations where flaps are not primarily closed. Levels of amputation depend on the condition and location of the injury or disease.
- Basic principles of amputation include using anesthesia, a tourniquet, fashioning adequate skin flaps, sectioning muscles and blood vessels, protecting cut nerve endings, and postoperative rehabilitation. Complications can include hematoma, infection, necrosis, contractures and phantom limb
Mr. K, an elderly male, presented to the emergency room via taxi with a head wound. He reported falling off his bicycle and hitting his head. His vitals and examination were notable for elevated blood pressure. He was given pain medication and instructed to get a head CT scan. After waiting for several hours, he began vomiting and his condition deteriorated. A repeat examination showed decreased responsiveness. The CT scan identified an epidural hematoma, a collection of blood between the skull and dura that results from head trauma. The case discusses the management of traumatic brain injuries like epidural hematomas through airway control, imaging, and transfer to higher level care when needed.
This document summarizes the anatomy, pathology, and epidemiology of breast cancer. It discusses the embryology, gross anatomy, histology, and molecular classification of the breast. It also describes the epidemiology of breast cancer, noting key risk factors like family history, age, reproductive history, hormone exposure, radiation exposure, BMI, physical activity, and diet. Screening and management of breast cancer is available at various levels of healthcare centers in India.
Varicose veins are dilated, tortuous veins in the legs caused by faulty valves that allow blood to flow backwards. Risk factors include heredity, prolonged standing, pregnancy, and tight clothing. Symptoms include heavy legs, cramps, and discolored skin. Treatment options range from compression stockings and sclerotherapy to surgery to remove or bypass sections of vein.
Atherosclerosis is a buildup of plaque in the arteries that can restrict blood flow. It often affects major arteries and risks include smoking, hypertension, and high cholesterol. Symptoms depend on the location but may include pain, numbness, or altered pulse. Diagnosis involves tests like Doppler and angiogram. Treatment focuses on risk
This document provides an overview of oesophageal anatomy, staging, and the diagnostic workup for oesophageal cancers. It describes the gross anatomy and course of the oesophagus, its arterial and venous blood supply, lymphatic drainage, and histology. Risk factors for oesophageal cancer are smoking, alcohol, and diet. Common symptoms are dysphagia and weight loss. The diagnostic workup includes imaging like barium swallow and CT scan, as well as endoscopy with biopsy. Staging is an important part of evaluating oesophageal cancers.
This document provides an overview of evaluating and managing a breast lump. It discusses the anatomy of the breast and describes the triple assessment approach including clinical examination, imaging studies, and biopsy. Common benign and malignant breast conditions are outlined. Fine needle aspiration, core needle biopsy, and excisional biopsy techniques are also summarized. The document reviews breast cancer staging and provides examples of evaluating specific breast lumps.
3er Curso Latino Americano de Cicatrización Avanzada en Heridas (II)Karen Pulido
This document discusses wound diagnosis and treatment by etiology, focusing on arterial and venous wounds. It provides 3 key points:
1. Arterial wounds are caused by ischemia due to macrovascular or microvascular disease. They typically occur on the extremities and are evaluated using pulses, capillary refill time, ABI, and other vascular tests. Treatment involves revascularization or wound care to address ischemia.
2. Venous wounds account for about 70% of lower extremity wounds and are caused by venous insufficiency and hypertension. They usually occur in the gaiter area. Risk factors include DVT history, surgery, prolonged standing, and obesity.
3. Both arterial and venous wounds are evaluated based
Ascaris lumbricoides is a large roundworm that infects the small intestine and is one of the most common parasitic infections in humans. It is transmitted through ingestion of Ascaris eggs from contaminated food, water, or soil. The life cycle involves development of larvae in soil followed by human infection through ingestion. Larvae hatch in the intestines and migrate through the lungs before returning to the intestines where they mature into adult worms. Infection may cause abdominal pain, vomiting, and respiratory symptoms. Diagnosis is usually made by examining a stool sample under a microscope. Treatment involves anthelmintic drugs and prevention focuses on handwashing and sanitation.
The thyroid gland is a butterfly-shaped endocrine gland located in the neck. It regulates metabolism and plays an important role in calcium homeostasis. The gland has two lobes joined by an isthmus and is located anterior to the trachea. It receives blood supply from the superior, middle, and inferior thyroid arteries and drains into internal jugular veins. The recurrent laryngeal nerves are at risk of injury during thyroid surgery as they pass back into the larynx.
This document discusses subarachnoid hemorrhage (SAH), which occurs when there is bleeding into the space between the brain and the thin tissues that cover the brain. The most common cause of SAH is the rupture of an intracranial aneurysm, which affects around 25,000-30,000 people in the US each year. The initial mortality rate is around 45% and over half of survivors are left with major neurological deficits. Diagnosis involves CT scans, lumbar puncture, and angiography. Treatment focuses on surgical clipping or coiling of the aneurysm as well as managing complications like vasospasm, hydrocephalus, and rebleeding through medical therapy.
Closed heart surgeries are performed without opening the heart or using a heart-lung bypass machine. They can be used to treat conditions like mitral stenosis, aortic stenosis, pulmonary embolisms, and some congenital heart defects. Rehabilitation after closed heart surgery focuses on gradually increasing a patient's mobility, strength, and endurance through exercises while avoiding complications. The goals are for patients to improve their functional capacity, quality of life, and reduce risks of issues like restenosis.
This document discusses hydrocephalus, including:
1) It defines hydrocephalus as an increased volume of cerebrospinal fluid in the ventricles due to overproduction or impaired absorption, causing increased pressure in the skull.
2) There are two main types - communicating/non-obstructive which involves overproduction or underabsorption of CSF, and non-communicating/obstructive which involves obstruction of CSF flow.
3) Clinical features vary depending on age but include increasing head size, irritability, vomiting, and signs of increased intracranial pressure like headache.
4) Treatment involves reducing CSF production medically or surgically placing a shunt to divert CSF out of
Acute scrotal pain requires rapid evaluation and treatment as certain conditions like testicular torsion are reversible if treated quickly but can lead to morbidity if not. The main causes are epididymitis, testicular torsion, and strangulated hernias. Physical exam focuses on scrotal swelling, tenderness, and cremasteric reflex to determine if surgical exploration is needed. Doppler ultrasound is usually the first imaging test to diagnose conditions like testicular torsion. Prompt surgical detorsion within 6 hours can save the testicle from infarction. Antibiotics are used to treat epididymitis while minor trauma may only require ice and analgesics. Complications include gangrene, abscess, infertility if not treated
This document provides information about several medical conditions. It begins by defining diabetes as an increased concentration of glucose in the blood and lists its main symptoms. It then discusses the history and facts about diabetes. The document also discusses cancer, defining it as uncontrolled growth and spread of abnormal cells. It lists the most common cancer types and their treatability. The document continues discussing allergies, arthritis, renal failure, asthma, and cardiovascular disease, defining each condition and providing additional details.
imaging of scrotum [Repaired] [Repaired].pptxdypradio
The scrotum contains the testes and epididymides. On ultrasound, the normal anatomy includes the oval testes with homogeneous echotexture and color flow. Potential pathological findings include infections like epididymitis, tumors such as seminomas which appear hypoechoic and well-defined, and traumatic injuries or torsion which may demonstrate absent flow. Malignancies require evaluation for metastases while infections require treatment with antibiotics. Imaging guides diagnosis and management of scrotal pathologies.
Varicose veins are dilated, tortuous subcutaneous veins caused by valvular incompetence. They develop due to primary or secondary valve failure, allowing blood to pool in the legs. Conservative treatments include compression stockings and lifestyle changes. Surgical options for varicose veins include traditional stripping and ligation, or minimally invasive procedures like endovenous laser ablation, radiofrequency ablation, and ultrasound-guided foam sclerotherapy which destroy veins through ablation or injection of sclerosing agents. Recurrence rates are lower with minimally invasive techniques. Duplex ultrasound is the gold standard for diagnosing and mapping varicose veins.
This document provides an overview of amputations, including:
- Indications for amputations include poor circulation, injury, infection, and tumors. The most common indication is poor circulation from conditions like diabetes or peripheral artery disease.
- Types of amputations include closed amputations where flaps are closed primarily and open amputations where flaps are not primarily closed. Levels of amputation depend on the condition and location of the injury or disease.
- Basic principles of amputation include using anesthesia, a tourniquet, fashioning adequate skin flaps, sectioning muscles and blood vessels, protecting cut nerve endings, and postoperative rehabilitation. Complications can include hematoma, infection, necrosis, contractures and phantom limb
Mr. K, an elderly male, presented to the emergency room via taxi with a head wound. He reported falling off his bicycle and hitting his head. His vitals and examination were notable for elevated blood pressure. He was given pain medication and instructed to get a head CT scan. After waiting for several hours, he began vomiting and his condition deteriorated. A repeat examination showed decreased responsiveness. The CT scan identified an epidural hematoma, a collection of blood between the skull and dura that results from head trauma. The case discusses the management of traumatic brain injuries like epidural hematomas through airway control, imaging, and transfer to higher level care when needed.
This document summarizes the anatomy, pathology, and epidemiology of breast cancer. It discusses the embryology, gross anatomy, histology, and molecular classification of the breast. It also describes the epidemiology of breast cancer, noting key risk factors like family history, age, reproductive history, hormone exposure, radiation exposure, BMI, physical activity, and diet. Screening and management of breast cancer is available at various levels of healthcare centers in India.
Varicose veins are dilated, tortuous veins in the legs caused by faulty valves that allow blood to flow backwards. Risk factors include heredity, prolonged standing, pregnancy, and tight clothing. Symptoms include heavy legs, cramps, and discolored skin. Treatment options range from compression stockings and sclerotherapy to surgery to remove or bypass sections of vein.
Atherosclerosis is a buildup of plaque in the arteries that can restrict blood flow. It often affects major arteries and risks include smoking, hypertension, and high cholesterol. Symptoms depend on the location but may include pain, numbness, or altered pulse. Diagnosis involves tests like Doppler and angiogram. Treatment focuses on risk
Similar to Arterial disorders PPT.pptx............. (20)
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Osteoporosis - Definition , Evaluation and Management .pdfJim Jacob Roy
Osteoporosis is an increasing cause of morbidity among the elderly.
In this document , a brief outline of osteoporosis is given , including the risk factors of osteoporosis fractures , the indications for testing bone mineral density and the management of osteoporosis
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
5. ATHEROSCLEROSIS BUERGER’S DISEASE
MOST COMMON
AGE GROUP – 6-7th DECADE
YOUNG MALE , SMOKER , AGE LESS THAN 40 YEARS
INVOLVES LARGE AND MEDIUM SIZE VESSELS
(ABDOMINAL AORTA , ILIAC, FEMORAL , POPLITEAL )
MAINLY SEEN IN LOWER LIMB
SMALL AND MEDIUM SIZED VESSELS (TIBIAL ,
PLANTAR , RADIAL )
LOWER LIMB > UPPER LIMB
6. BUERGER’S DISEASE
• AKA THROMOANGITIS OBLITERANS
• INVOLVES SMALL AND MEDIUM SIZED VESSELS
• T – TIBIAL
• P – PLANTAR
• R – RADIAL
• EXTENDS FROM DISTAL TO PROXIMAL
• INFLAMMATORY PROCESS INVOLVES – ARTERY ,
VEINS AND NERVES
7. CLINICAL FEATURES
• TRIAD
• R – RAYNAUD’S PHENOMENON
• I- INTERMITTENT CLAUDICATION
• M- MIGRATORY SUPERFICIAL
THROMOBOPHLEBITIS
9. DIAGNOSIS-
• IOC- FOUR LIMB ANGIOGRAPHY
• THERE IS CHARACTERISTICS COLLATERLS PRESENT
KNOWN AS CORKSCREW COLLATERLS .
• ABPI- ANKLE BRACHIAL PRESSURE INDEX
• ABPI- SYSTOLIC BP ANKLEARM
14. TREATMENT
• ABSTINENCE FROM SMOKING.
• VASODILATORS –XANTHINOL NICOTINATE PENTOXYPHYLINE.
• LUMBAR SYMPATHECTOMY- IS DONE ONLY FOR REST PAIN (DUE TO CUTANEOUS
ISCHEMIA ) . BECAUSE BLOOD SUPPLY OF MUSCLES IS NOT UNDER CONTROL OF
SYMPATHETIC SYSTEM.
• FOR GANGRENE – AMPUTATION.
15. ATHEREOSCLEROSIS
• OCCURS IN >5TH DECADE
• MALES=FEMALES
• LOWER LIMB > UPPER LIMB
• INVOLVES ARTERY
• INVOLVES LARGE TO MEDIUM SIZED
VESSELS
• SPREAD – PROXIMAL TO DISTAL SPREAD
17. ARTERIAL ULCERS
• LOCATION – LATERAL SURFACE OF ANKLE /
DISTAL DIGITS
• PUNCHED OUT ULCER
• INTENSLY PAINFUL
• DISTAL PULSES NOT PALPABLE
• THIN SHINY SKIN
• LACK OF HAIR
• BRITTLE NAILS
18. • MICROANGIOPATHY > ENDOTHELIAL DYSFUNCTION > ISCHEMIA
> PUNCHED OUT ULCER
• DIAGNOSIS IS MADE CLINICALLY
• DOPPLER IS PERFORMED TO ASSESS THE BLOOD FLOW.
• TREATMENT –
REVASCULARIZATION PROCEDURE DONE
FOR INFECTED ULCERS- ANTIBIOTICS + DEBRIDEMENT DONE.
19. RAYNAUD’S PHENOMENON -
• ITS AN EPISODIC DIGITAL ISCHEMIA ON
EXPOSURE OF COLD , EMOTIONAL STRESS, USE
OF VIBRATING TOOLS.
• MANIFESTED BY SEQUENTIAL DEVELOPMENT OF
DIGITAL BLANCHING , CYANOSIS , REDNESS IN
FINGERS AND TOES
• MOST COMMON IN FINGERS > TOES