This document discusses applied innovations in machine learning and soft computing in the United States. It begins with introducing machine learning and soft computing techniques, including artificial neural networks, clustering, decision trees, fuzzy logic and Bayesian networks. Then, it discusses several applications: energy management using meta-heuristics controllers and cloud/IoT; human-machine interaction like speech recognition; and infrastructure/transport like navigation, self-driving cars and drones. Finally, it outlines research areas like efficiency optimization of dynamic systems, humanizing machine interactions, and hyper-personalization of automated systems.