Apache Cordova is an open-source framework that allows developers to use standard web technologies like HTML, CSS, and JavaScript to build applications that can be deployed across various mobile and desktop platforms. It works by packaging the application's code and assets into a wrapper application that loads the content into a webview. Plugins can be added to access device capabilities. The Cordova CLI provides commands for creating, building, and running Cordova projects across platforms in a consistent way. Frameworks like Angular and UI frameworks like Ionic can be used to organize larger Cordova applications.