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Antibacterial sulphonamides
1.
ANTIBACTERIAL SULPHONAMIDES SULPHONAMIDES ARE ANTIBACTERIAL SUBSTANCE
WITH A SULPHONAMIDO (So2NH2) GROUP. SULPHANILAMIDE IS THE SIMPLEST OF SULPHONAMIDES.
2.
• ALL SULPHONAMIDES
MAY BE CONSIDER TO BE DERIVTAIVES OF SULPHANILAMIDES WHICH IS P- aminobenzene sulphonamide • H2N SO2NH2 SULPHANILAMIDE
3.
CLASSIFICATION • A. CHEMICAL
CLASSIFICATION • A) N1 SUBSTITUDED SULPHONAMIDES : -- • 1. SULPHACETAMIDE • 2. SULPHAGUANIDINE • 3. SULPHADIAZINE • 4. SULPHATHIAZOLE • 5. SULPHADIMETHOXINE • 6. SULPHAFURAZOLE • 7. SULPHAMETHOXAZOLE • 8. SULPHAMERAZINE • 9. SULPHAMETHAZINE • 10. SULPHASOMIDINE • 11. SULPHAMETHOXINE • 12. SULPHADOXINE
4.
N1 AND N4
SUBSTITUTED SULPHONAMIDES • 1. Succinylsulphathiazole • 2. Phthalylsulphathiazole • N4 SUBSTITUTED SULPHONAMIDES:-- • Prontosil • SULPHONAMIDES WITHOUT AROMATIC AMINO GROUP:-- • Mefinide
5.
2. Pharmacological classification •
SULPHONAMIDES USED IN INTESTINAL INFECTION:-- • Sulphaguanidine • Succinylsulphathiazole • Phthalylsulphathiazole • SULPHONAMIDES USED IN EYE INFECTION:- • Sulphacetamide
6.
• SULPHONAMIDES IS
USED IN SYSTEMIC INFECTION:-- • SULPHADIZINE • SULPHATHIAZOLE • SULPHADIMETHOXINE • SULPHAPHENAZOLE • SULPHAFURAZOLE • SULPHAMETHOXAZOLE • SULPHAMERAZINE • SULPHAMETHAZINE • SULPHASOMADINE • SULPHADIMETHOXINE • SULPHADOXINE
7.
• SULPHONAMIDE USED
IN URINARY INFECTION:-- • Sulphafurazole • Sulphaphenazole • 3. CLASSIFICATION BASED ON DURATION OF ACTION:-- • *SHORT ACTING (4 to 8 hours) • Sulphadizine • Sulphathiazole • Sulfisoxazole • sulphadizine • sulphamerazine • Sulphamethazine • Sulphasomidine • sulphamethizole
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