MEDICINAL CHEMISTRY 5TH SEM. NOTES

1. gent

2. 1
• Introduction
• Cil1
assificatiion
1
• SAR of H1
ypolip'idemic dr
rugs
1
• MOA of H
lyp1
01
lipidemic drugs
1
• Drug stru1
ctures
1
• Uses

3. ••

4. c .1
assificatior1
•'.-! HMG CoA redu:ctas,
e i:nhibitor [ s,
tat1
rn]
1
E~g, L,
ovastatiin, p,rav,
astati1
n
• LiiP}~~tot1
i@flip,ase act1
iv:at,
Q:r
~ g~
Ci,o;fjbr,
ate ,fe:
n,
ofibratet .
. .- - .... -
~ -
'
·•• I -
l
Riho ::.,
,
~ • . ~f; I ~
~ ;JD~tfillJifiK©
~~
I[· ..· ,
.e]1

5. HMG COA Reductase enzyme is essential
tor cholesterol synthesis pathway
.J1 statin
Inhibit the HMG COA reductase enzyme so
decrease cholesterol level
J1 Slatin
Anti-inflamatory effect on the blood vessel
= wall fl
less Athetoscl,
e1
ro1
s1
is
fpptcom]

6. SAil
Comman famra li,r·all HfdGJUS
2. · • 1
1:Dnta•ntna. pradnareqalN In•1
lwu
Lydral,-1&1 HO ~•--....._ ·
- -
, H
,,
H
H
fPO com

7. • This is first choise drug for dyslipidaemia
in diabetics
• Stain are first choise drug for primery
hyperlipidaemias with raised LDL & CH
level
• Statins reduce the risk of heart attack,
stroke & even de1
ath for f
he1
art diseases

8. CH~
I ,a
[Aromatic rin&)~(Spaecr.·group,] --c............- -
C~
I ......_OH
, .
lsobutyric acid gro~p ·
is essential fur activiay~ cH3
CoqkJunds containing an r
ester. s.11:h as clafibralc and fenofibratc are
prodrugs and n:quirc in vivo1 hyd~olysis.
• 1 S11b1titulion. at the p.-a position ofthe aromai.
c ring with achlor1
0 group
ora chlorine·c.ontainin.g isof»opy·IIring ~ucc:·,
c,ompomd w.
itb
significant.ly Ions~ halfIire*
, :
Most:ofdn1gs1 1
C'OAlain a phenoxyimbutyric acid. lhe additi1
on ofan ~
propyl spacs. as seen in gemfibrozil1
results in an acliv,e drug,~
-

9. • Headache, nausea, bowel upset, rashes
• Rise,
s in serum transaminase
• Myopathy Disease
fppt oom

10. MOA OF FIBRAT
USES
Fenofibrate is used along with aproper diet to
help lower 'bad' cholesteFiol &fats
S1D1
E EFFECT
Cause gallstones, liver problems,nausealvomiting
Stomach pain

11. In mtaal hype{tipkfania
ltli:im■ldFildlinllt
■g • MMJ1n111•
1~rff1gCip1
Ix •N!llt1
. •
1
1
E-
I
1 P--• e PINII.,...,.

12. 11 _
I f
Llpnar
1
2Pmg ifldllldJI
A torvasratbl
~ 11 ll!lilll
L.......-111.a.lii
lltllMvl■n- - 3515
I !!i,f r,,,r r, '• ! ::,. ,;.. 1 ,F', 1 ~ ,
- - - - - - - - - - - - - - - - - - - -
: 'H :.. mlt·!f 00 TA». f I ~ I
- -
IIIIIIC' - •<PH ••
.· ~·.......
-•
II O llftQ • _,.