Answer:
SOCS are the supressor of cytokine signaling proteins and are negative feedback regulators of
JAK-STAT signaling pathway. It means the SOCS are inhibitors of activation of JAK-STAT
pathway proteins.
As JAK-STAT pathway plays essential roles in initiation and development of cancers, mutation
in SOCS family proteins could be one of the mechanism of abnormal activation of STAT .
The expression of SOCS are inversly related to the STAT-3 activation. Hence overexpression of
SOCS may not be lead to cancer risk. Overexpression of SOCS may supress the cytokine
signaling or inhibit cytokine signaling by
(i) Blocking STAT recruitment to the cytokine receptor
(ii) may target protein for degradation
(iii) bind to JAK and inhibit their kinase
(iv) target JAK for degradation via proteosome pathway
Solution
Answer:
SOCS are the supressor of cytokine signaling proteins and are negative feedback regulators of
JAK-STAT signaling pathway. It means the SOCS are inhibitors of activation of JAK-STAT
pathway proteins.
As JAK-STAT pathway plays essential roles in initiation and development of cancers, mutation
in SOCS family proteins could be one of the mechanism of abnormal activation of STAT .
The expression of SOCS are inversly related to the STAT-3 activation. Hence overexpression of
SOCS may not be lead to cancer risk. Overexpression of SOCS may supress the cytokine
signaling or inhibit cytokine signaling by
(i) Blocking STAT recruitment to the cytokine receptor
(ii) may target protein for degradation
(iii) bind to JAK and inhibit their kinase
(iv) target JAK for degradation via proteosome pathway.
AnswerSOCS are the supressor of cytokine signaling proteins and a.pdf
1. Answer:
SOCS are the supressor of cytokine signaling proteins and are negative feedback regulators of
JAK-STAT signaling pathway. It means the SOCS are inhibitors of activation of JAK-STAT
pathway proteins.
As JAK-STAT pathway plays essential roles in initiation and development of cancers, mutation
in SOCS family proteins could be one of the mechanism of abnormal activation of STAT .
The expression of SOCS are inversly related to the STAT-3 activation. Hence overexpression of
SOCS may not be lead to cancer risk. Overexpression of SOCS may supress the cytokine
signaling or inhibit cytokine signaling by
(i) Blocking STAT recruitment to the cytokine receptor
(ii) may target protein for degradation
(iii) bind to JAK and inhibit their kinase
(iv) target JAK for degradation via proteosome pathway
Solution
Answer:
SOCS are the supressor of cytokine signaling proteins and are negative feedback regulators of
JAK-STAT signaling pathway. It means the SOCS are inhibitors of activation of JAK-STAT
pathway proteins.
As JAK-STAT pathway plays essential roles in initiation and development of cancers, mutation
in SOCS family proteins could be one of the mechanism of abnormal activation of STAT .
The expression of SOCS are inversly related to the STAT-3 activation. Hence overexpression of
SOCS may not be lead to cancer risk. Overexpression of SOCS may supress the cytokine
signaling or inhibit cytokine signaling by
(i) Blocking STAT recruitment to the cytokine receptor
(ii) may target protein for degradation
(iii) bind to JAK and inhibit their kinase
(iv) target JAK for degradation via proteosome pathway
