Anal cancer 7908
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Cancer treatment regimens involve complex selection, dosing, and administration of drugs and management of toxicities. Treatment requires experienced healthcare teams to modify drug doses and schedules based on individual patient factors like prior treatments and medical history. The optimal delivery of cancer treatments balances FDA-approved and experimental options selected for each patient.
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讲座：英文网站
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Anal cancer 7908
- 1. CANCER TREATMENT REGIMENS The selection, dosing, and administration of anticancer agents and the management of associated toxicities are complex. Drug dose modifications and schedule and initiation of supportive care interventions are often necessary because of expected toxicities and because of individual patient variability, prior treatment, and comorbidities. Thus, the optimal delivery of anticancer agents requires a healthcare delivery team experienced in the use of such agents and the management of associated toxicities in patients with cancer. These cancer treatment regimens may include both FDA-approved and unapproved uses/regimens and are provided as references only to the latest treatment strategies. Clinicians must choose and verify treatment options based on the individual patient. NOTE: Grey shaded boxes contain updated regimens. Gastrointestinal Cancers Anal Cancer 1
- 2. ANAL CANCER REGIMEN DOSING Localized Cancer 5-fluorouracil (5-FU) + mitomycin (Mutamycin; MTC) + radiotherapy1, 2 Days 1–4 and Days 29–32: 5-FU 1,000mg/m2 /day plus Days 1 and 29: Mitomycin 10mg/m2 IV + radiotherapy 45–59Gy (min dose of 45Gy in 25 fractions of 1.8Gy over 5 weeks). Metastatic Cancer 5-FU + cisplatin (Platinol; CDDP)1 Days 1–5: 5-FU 1,000 mg/m2 /day IV plus Day 2: Cisplatin 100mg/m2 IV. References 1. NCCN Clinical Practice Guidelines in Oncology™.Anal Carcinoma. v 1.2012.Available at: http://www.nccn.org/ professionals/physician_gls/pdf/anal.pdf.Accessed October 11, 2011. 2. Ajani JA,Winter KA, Gunderson LL, et al. Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial. JAMA. 2008;299(16):1914–1921. (Revised 11/2011) Copyright © 2011 by Haymarket Media Inc. 2