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Alzheimer's

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Alzheimer's disease is a progressive brain disease that destroys memory and thinking skills. It starts with mild memory loss and progresses to severe brain damage. Diet and lifestyle factors may help reduce the risk of Alzheimer's. Studies show foods like berries, walnuts, fish, and spices like turmeric that contain antioxidants and anti-inflammatory compounds may protect brain health and function.

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[object Object],[object Object],[object Object],[object Object],Dr.Alois Alzheimer
Signs & Symptoms Early signs: Forgetting recent events and people’s and places Difficulty solving simple math problems Later signs Forgetting how to do simple activities like brushing teeth or combing hair Forgetting names of common things like table and cup
Facts & Statistics ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Okiwana Lifestyle Unhurried calm lifestyle A lot of exercise Spend a lot of time with family Meditation , qi gong, tai chi
[object Object],[object Object]
[object Object],[object Object],[object Object]
Study 1 ,[object Object],[object Object],[object Object]
Polyunsaturated Fatty Acids (PUFA) ,[object Object],[object Object],[object Object],[object Object]
 
[object Object]
Omega-3 & Mood ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Omega-3 & Mood conclusion ,[object Object]
Walnuts ,[object Object]
[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object],[object Object],Polyunsaturated Fatty Acids (PUFA)
DHA cont. ,[object Object],[object Object],[object Object],[object Object],Group 1 (n=90) Group 2 (n=85) 400 mg DHA per day Placebo
DHA & Stress ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Group 1 – omega 3 group Group 2 – Control group 0.7 gram DHA and 0.6 gram EPA for 6 months Placebo for 6 months Both groups had similar MMSE scores after 6 months
[object Object],[object Object],[object Object],[object Object],Mouse model Diabetic rat model Cultured human cell
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Cross-sectional (at baseline) Longitudinal (after 6 years) No relationship between fish (omega-3) consumption and cognitive preformance No relationship between fish (omega-3) consumption and cognitive preformance
National institute of health (NIH) ,[object Object],[object Object],[object Object],[object Object],[object Object],Group 1 Group 2 2g/day DHA Placebo
Omega-3 Conclusion ,[object Object]
Vitamin E ,[object Object],[object Object],Group 1 Group 2 Aged rats fed Vitamin E Control group At baseline ,[object Object],After Vit E consumption Learned the place with a marked speed after 5 trails No change After 48 hours without trial Marked retention of maximum memory function 60 % Memory los
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object]
Berry Fruit ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Berry Fruit cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mulberry ,[object Object],[object Object],[object Object],[object Object],[object Object]
Concord Grape Juice ,[object Object],[object Object],[object Object],[object Object],[object Object],Group 1 Group 2 Concord grape juice for 12 weeks Placebo for 12 weeks
Grapes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Group1 Group 2 Water + Grape seed extract Plain water
Grapes cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],Group 1 Group 2 Drank 15-21 Oz Concord grape juice Placebo
Coffee Bean ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Coffee Bean cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Caloric Restriction ,[object Object],[object Object],[object Object]
Phosphotidyl Choline ,[object Object],[object Object]
Garlic ,[object Object]
SPICES
[object Object],[object Object],[object Object]
Curcumin ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Brain Food
[object Object],[object Object]
Lemongrass ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Passionflower ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Velerian ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ginkgo Biloba ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ginkgo Biloba cont. ,[object Object],[object Object]
Ginseng ,[object Object],[object Object],[object Object]
Ashwagandha ,[object Object],[object Object]
Dietary Risk Factor ,[object Object],[object Object],[object Object],[object Object]
In Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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Alzheimer's

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  • 3. Signs & Symptoms Early signs: Forgetting recent events and people’s and places Difficulty solving simple math problems Later signs Forgetting how to do simple activities like brushing teeth or combing hair Forgetting names of common things like table and cup
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Editor's Notes

  1. 1- US national institute of health – National Institute on Aging. 2- Dr. William Thies, chief medical and scientific officer at the Alzheimer's Association in Chicago on CBS news (Jan 2010): http://www.cbsnews.com/video/watch/?id=6086569n
  2. Understanding Alzheimer’s disease from U.S DEPARTMENT OF HEALTH AND HUMAN SERVICES-Public Health Service National Institutes of Health National Institute on Aging: www.alzheimers.nia.nih.gov
  3. 1- Dr. William Thies, chief medical and scientific officer at the Alzheimer's Association in Chicago on CBS news (Jan 2010): http://www.cbsnews.com/video/watch/?id=6086569n 2- US national institute of health – National Institute on Aging. 3- CDC-Alzheimer’s disease : http://www.cdc.gov/nchs/fastats/alzheimr.htm 4- http://www.searo.who.int/en/section1174/section1199/section1567_6740.htm 5- http://www.searo.who.int/en/Section1174/Section1199/Section1567/Section1823_8066.htm
  4. WHO Modern Lifestyles Causing Disease Epidemic: http://www.wpro.who.int/media_centre/press_releases/pr_20020918.htm Scientists shed light on why Okinawans have world's longest average lifespan From Associated Press, Oct 7, 2001 : http://www.okicent.org/news/associated_press.html Image: microsoft clipart: http://office.microsoft.com/en-us/images/religion-CM079001947.aspx#pg:2|
  5. The Food Bible by Gillian McKeithe- Food and the stages of life, AGING p147-148 Image: microsoft clupart
  6. Nutrition Annual Editions 10/11, article 22: Alzheimer’s– The Case for Prevention by Oliver Tickell
  7. Nutrition Annual Editions 10/11, article 22: Alzheimer’s– The Case for Prevention by Oliver Tickell Martha Clare Morris. Dietary Fats and the Risk of Incident Alzheimer Disease. Arch Neurol. 2003;60:194-200 J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005
  8. 2003 study in the Archives of Neurology from Nutrition Annual Editions 10/11, article 22: Alzheimer’s– The Case for Prevention by Oliver Tickell
  9. Nutrition Annual Editions 10/11, article 22: Alzheimer’s– The Case for Prevention by Oliver Tickell 2) J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005
  10. Modern Nutrition in Health and Disease, 10 th edition, Page 108
  11. J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005
  12. J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005
  13. The jungle effect by Daphne Miller, MD. Page: vi
  14. J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005 Image: microsoft clipart
  15. NUTRITION annual edition,Article 35:Brain food by Linda Milo Ohr, September 2008 page 134-136 Original reference: Food technology, september 2008 pp. 65-68
  16. NUTRITION annual edition,Article 35:Brain food by Linda Milo Ohr, September 2008 page 134-136 Original reference: Food technology, september 2008 pp. 65-68
  17. James Josep. Nutrition, Brain Aging, and Neurodegeneration. The Journal of Neuroscience, October 14, 2009 • 29(41):12795–12801 John M. Ringman. A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease. Curr Alzheimer Res. 2005 April ; 2(2): 131–136
  18. Nutrition Annual Editions 10/11, article 22: Alzheimer’s– The Case for Prevention by Oliver Tickell
  19. NUTRITION annual edition,Article 35:Brain food by Linda Milo Ohr, September 2008 page 134-136 Original reference: Food technology, september 2008 pp. 65-68
  20. J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005
  21. J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005 Image: Microsoft clipart http://office.microsoft.com/en-us/?CTT=97
  22. J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005
  23. *Any score greater than or equal to 25 points (out of 30) is effectively normal (intact). Below this, scores can indicate severe (≤9 points), moderate (10-20 points) or mild (21-24 points) -  Mungas, D (1991). "In-office mental status testing: a practical guide". Geriatrics 46 (7): 54–56 Yvonne Freund-Levi,, 􏰈-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study, Arch Neurol .2006;63:1402-1408
  24. NUTRITION annual edition,Article 35:Brain food by Linda Milo Ohr, September 2008 page 134-136 Original reference: Food technology, september 2008 pp. 65-68
  25. Ondine van de Rest, Intakes of (n-3) Fatty Acids and Fatty Fish Are Not Associated with Cognitive Performance and 6-Year Cognitive Change in Men Participating in the Veterans Affairs Normative Aging Study. J. Nutr. 139: 2329–2336, 2009.
  26. NUTRITION annual edition,Article 35:Brain food by Linda Milo Ohr, September 2008 page 134-136 Original reference: Food technology, september 2008 pp. 65-68
  27. Lim WS, Gammack JK, Van Niekerk JK, Dangour A. Omega 3 fatty acid for the prevention of dementia. Cochrane Database of Systematic Reviews 2006, Issue 1. Art. No.: CD005379. DOI: 10.1002/14651858.CD005379.pub2
  28. Hirokatsu TAKATSU. Effect of Vitamin E on Learning and Memory Deficit in Aged Rats. Journal of Nutritional Science and Vitaminology. Vol. 55 (2009) , No. 5 pp.389-393
  29. Elizabeth E. Devore, .Dietary Antioxidants and Long-term Risk of Dementia. Arch Neurol . 2010;67(7):819-825.
  30. Nutrition Annual Editions 10/11, article 22: Alzheimer’s– The Case for Prevention by Oliver Tickell
  31. James Josep. Nutrition, Brain Aging, and Neurodegeneration. The Journal of Neuroscience, October 14, 2009 • 29(41):12795–12801
  32. BARBARA SHUKITT-HALE, Berry Fruit Supplementation and the Aging Brain. J. Agric. Food Chem. 2008, 56, 636–641
  33. Ping-Hsiao Shih. Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease. Journal of Nutritional Biochemistry xx (2009) xxx–xxx
  34. Robert Krikorian. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. British Journal of Nutrition (2010), 103, 730–734 doi:10.1017/S0007114509992364
  35. NUTRITION annual edition,Article 35:Brain food by Linda Milo Ohr, September 2008 page 134-136 Original reference: Food technology, september 2008 pp. 65-68
  36. NUTRITION annual edition,Article 35:Brain food by Linda Milo Ohr, September 2008 page 134-136 Original reference: Food technology, september 2008 pp. 65-68 Image: Microsoft clipart http://office.microsoft.com/en-us/?CTT=97
  37. Chihiro Tohda, Search for Natural Products Related to Regeneration of the Neuronal Network. Neurosignals 2005;14:34–45 DOI: 10.1159/000085384 Joan Lindsay. Risk Factors for Alzheimer’s Disease: A Prospective Analysis from the Canadian Study of Health and Aging. Am J Epidemiol 2002;156:445–53. Image: Microsoft clipart http://office.microsoft.com/en-us/?CTT=97
  38. G. W. ARENDASH. CAFFEINE PROTECTS ALZHEIMER’S MICE AGAINST COGNITIVE IMPAIRMENT AND REDUCES BRAIN 􏰁-AMYLOID PRODUCTION. Neuroscience 142 (2006) 941–952 Image: Microsoft clipart http://office.microsoft.com/en-us/?CTT=97
  39. 1- James Joseph: Nutrition, Brain Aging, and Neurodegeneration. The Journal of Neuroscience, October 14, 2009 • 29(41):12795–12801 • 12795 2- M.P. Mattson: Emerging neuroprotective strategies for Alzheimer’s disease: dietary restriction, telomerase activation, and stem cell therapy. Exp Gerontol. 2000 Jul;35(4):489-502.
  40. J.-M. BOURRE. DIETARY OMEGA-3 FATTY ACIDS AND PSYCHIATRY: MOOD, BEHAVIOUR, STRESS, DEPRESSION, DEMENTIA AND AGING. The Journal of Nutrition, Health & Aging© Volume 9, Number 1, 2005 Image:: Microsoft clipart http://office.microsoft.com/en-us/?CTT=97
  41. Rahman K. Garlic and aging: new insights into an old remedy. Ageing Res Rev 2003; 2: 39-56. PMID: 12437995
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  43. James Josep. Nutrition, Brain Aging, and Neurodegeneration. The Journal of Neuroscience, October 14, 2009 • 29(41):12795–12801 John M. Ringman. A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease. Curr Alzheimer Res. 2005 April ; 2(2): 131–136 Rahul Agrawal. Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat. Pharmacological Research 61 (2010) 247–252
  44. James Josep. Nutrition, Brain Aging, and Neurodegeneration. The Journal of Neuroscience, October 14, 2009 • 29(41):12795–12801 John M. Ringman. A Potential Role of the Curry Spice Curcumin in Alzheimer’s Disease. Curr Alzheimer Res. 2005 April ; 2(2): 131–136
  45. Leite JR, Seabra Mde L, Maluf E, et al. Pharmacology of lemongrass (Cymbopogon citratus Stapf.). III. Assessment of eventual toxic, hypnotic and anxiolytic effects on humans. J Ethnopharmacol 1986; 17: 75-83
  46. Akhondzadeh S, Naghavi H, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001; 26: 363-367.PMID: 11679026
  47. Carlini EA. Plants and the central nervous system. Pharmacol Biochem Behav 2003; 75: 501-512. PMID: 12895668  
  48. Birks J, Grimley EV, Van Dongen M. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2002; (4): CD003120 . PMID: 19160216 2)Gillian McKeith’s Food Bible- food and the stages of life- aging. Page 157
  49. Birks J, Grimley EV, Van Dongen M. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2002; (4): CD003120 . PMID: 19160216
  50. Chihiro Tohda, Search for Natural Products Related to Regeneration of the Neuronal Network. Neurosignals 2005;14:34–45 DOI: 10.1159/000085384 NUTRITION annual edition,Article 35:Brain food by Linda Milo Ohr, September 2008 page 134-136 Original reference: Food technology, september 2008 pp. 65-68
  51. Chihiro Tohda, Search for Natural Products Related to Regeneration of the Neuronal Network. Neurosignals 2005;14:34–45 DOI: 10.1159/000085384
  52. 1- Heart Disease - Mayo clinic: http://www.mayoclinic.com/health/heart-disease/HB00016 2- Nutrition Annual Editions 10/11, article 22: Alzheimer’s– The Case for Prevention by Oliver Tickell
  53. James Joseph: Nutrition, Brain Aging, and Neurodegeneration. The Journal of Neuroscience, October 14, 2009 • 29(41):12795–12801 • 12795 Nutrition Annual Editions 10/11, article 22: Alzheimer’s– The Case for Prevention by Oliver Tickell