The document summarizes two symposia held in New Zealand in August 2014 about the effects of alcohol and marijuana on the adolescent brain. Experts from universities in New Zealand and the US presented research showing that substance use during adolescence can have long-lasting negative impacts on brain development. The research found that both alcohol and marijuana use were linked to poorer cognitive performance and mental health issues. Specifically, alcohol use was shown to correlate with differences in brain function before and after drinking began in teens. Females also appeared more vulnerable than males. Marijuana use was associated with increased risks of dropping out of school and mental health problems. Both sessions emphasized that substance use has greater detrimental effects during adolescence compared to adulthood.