The American Journal of Physiology-Lung Cellular and Molecular Physiology annual report summarizes accomplishments and challenges in 2015-2016. Key accomplishments include a 20% increase in research manuscript submissions, an increased impact factor of 4.08 making it the highest ranked basic lung research journal, and a 60% acceptance rate for research manuscripts. The journal also published three of the most highly cited articles among all APS journals and selected thirteen manuscripts for the APSselect program which highlights innovative, high impact research.