This document discusses different artificial insemination methods for pigs (AI, IUI, DIUI) and promotes a new method called AMG Series. It summarizes the performance of farms using the AMG Series method, finding increases in annual profit from $424,944 for sows and $252,716 for gilts, with returns on investment ranging from 498-4866% for sows and 662-5431% for gilts. The document argues the AMG Series places semen directly in both horns simultaneously, protecting semen from bacteria and ensuring rapid transport to the uterus for higher conception rates.
One-Liner
BAIBYS™ develops an AI and robotics-based COMPLETELY AUTONOMOUS system for sperm selection for IVF, which will improve success rates, reduce birth defects, and raise clinics’ throughput.
The problem
According to the WHO guidelines, in a healthy man, 96% of the sperm cells are abnormal. Natural fertilization overcomes this problem by having millions of sperm cells compete on one egg through various selection processes such that only the best one wins. However, in IVF today, the injected sperm cells are selected arbitrarily. Thus, the natural sperm selection process is bypassed, leading to fewer successful pregnancies and more birth defects. A manual selection at high magnification was proposed, showing higher success rates and reduced birth defects (NEJM, 2001). Nevertheless, this manual procedure was not widely adopted since it was lengthy (3h vs. a few minutes), subjective and inconsistent, required extensive training, and was therefore expensive.
BAIBYS’ solution
BAIBYS’ system performs the same selection process, based on the same well-accepted criteria, COMPLETELY AUTONOMOUSLY, in a fraction of the time and cost of the current manual process. The user needs only to place a cartridge with the sperm sample into the console and press a button, and the system will autonomously identify the optimal cells and will robotically transfer them to a separate droplet in the cartridge. Eliminating the drawbacks of the manual process by making it fast, objective, consistent, without trained personnel, and affordable, would allow its use in every IVF cycle, improving success rates, and reducing birth defects, while raising the clinics’ throughput and reputation.
Impact
The system shall revolutionize the IVF process by reducing the financial and emotional crisis involved with it by saving failed IVF treatments, reducing the economic burden on health systems, raising IVF clinics throughput, making IVF more accessible globally, and most importantly, reducing birth defects and helping more families in having healthy babies.
Market
The global IVF market is estimated at $41B by 2026 and growing at >10% CAGR. With 5M IVF treatments in the world forecasted for 2026, at >$200 disposable cartridge cost, plus consoles and service sales, BAIBYS’ Total Addressable Market exceeds $1B.
Progress
After a seed round of $2M in Q1/2021 (mostly from angels who are international experts in andrology and fertility clinic owners) and completing a working prototype, we closed an additional $2M investment by an Israeli VC to lead a $3-4M round. The use of proceeds is to develop the product, conduct clinical trials, and get regulatory clearances. Our seed round investors participated in this round as well.
This document discusses artificial insemination (AI) in cattle. It defines AI as the introduction of semen into the oviduct or uterus by means other than sexual intercourse. The key advantages of AI include allowing desirable bull genetics to be passed on to more offspring more quickly, increasing bull usage efficiency, and reducing disease transmission. However, AI also has disadvantages like requiring good estrus detection and proper semen storage. The document describes common methods for collecting bull semen, either using an artificial vagina or electric stimulation. It also outlines the process for artificially inseminating cattle.
Precision Dairy Monitoring Opportunities and ChallengesJeffrey Bewley
This presentation provides an introduction to precision dairy monitoring. The wide range of opportunities for future dairy management are discussed. Then, the challenges of turning these dreams into reality are covered.
CATTLE MEDICAL DIAGNOSIS AND PREDICTION USING MACHINE LEARNINGIRJET Journal
This document describes a machine learning system to diagnose cattle health issues using images. The system uses cameras to capture images of the eyes, nose, and neck of cattle. These images are analyzed by a deep learning model trained on a dataset of healthy and infected cattle images. The model can detect common symptoms of respiratory diseases and output whether each body part appears healthy or infected. This automatic diagnosis system aims to improve cattle health monitoring compared to traditional manual methods, reducing costs for farmers and preventing disease outbreaks.
Slide 1: Title: EMERGING PEDIATRIC TECHNOLOGIES
By: Falakaara Saiyed
This presentation is about inventions in pediatric technologies.
Slide 2: Introduction
Children require specialized, compassionate and comprehensive care that supports every stage of their lives.
Innovation will help health care providers improve their care of pediatric patients
The Food and Drug Administration (FDA) has recognized the need for medical devices for the pediatric population and is responding with initiatives that support the development of safe and effective pediatric medical devices.
Slide 3: New innovative technology in the pediatric pipeline
Caring for the pediatric patient population — whether neonate, infant, child or adolescent — is complex.
FDA has implemented initiatives to increase the availability of pediatric medical devices, including identifying barriers to the development of pediatric devices and incorporating known information about other populations to support labeling of existing devices for pediatric indications.
As a result, new products indicated for pediatric patients will continue to be released and physician and patient awareness of the availability of these products will increase, leading to greater penetration of pediatric devices and driving market growth.
Slide 4: Currently Available Products
MyoPro 2 orthosis
Flourish pediatric esophageal atresia device
CGM G6
Pivo Needle-Free Blood Draw Technology
Owlet Smart Sock 2
Slide 10: Products in Clinical trials
Amplatzer duct occluder II AS
OtoNexus ultrasound device
Magnamosis magnetic compression anastomosis system
Dynamic spinal alignment brace
Slide 15: Products in Development
EOPatch
StethAid digital stethoscope
Perf-Fix tympanoplasty gel patch
Tabla pneumonia detector
Synthetic Muscle
REFERENCES
“Emerging Pediatric technologies”, Pediatric Technology Watch, Vizient, Vol.1.,2018.
“Emerging Pediatric technologies”, Pediatric Technology Watch, Vizient, Vol.1.,2018.
Leveraging existing clinical data for extrapolation to pediatric uses of medical devices; guidance for industry and Food and Drug Administration staff., 2016
Pediatric medical devices, Food and Drug Administration website.
Smith WM, Riddell F, Madon M, Gleva MJ. “Comparison of diagnostic value using a small, single channel, P-wave centric sternal ECG monitoring patch with a standard 3-lead Holter system over 24 hours”, Am Heart J., 2017;185:67-73.
learn about various methods of contraception , how to use various contraceptive devices and also learn about the hormonal and emergency contraceptives' methods. here is the detail of post coital methods to prevent pregnancy and terminal methods for sterilization.
This document discusses various contraceptive methods including barrier methods like condoms, diaphragms, and sponges as well as chemical and hormonal methods. It provides details on how each method works, effectiveness rates, advantages and disadvantages. Intrauterine devices (IUDs) are explained in depth, including types like copper IUDs and hormone-releasing IUDs. Hormonal contraceptives like combined oral contraceptive pills are also described.
Production and delivery of thermotolerant vaccine against peste des petits ru...ILRI
Presentation by Michel Dione, Cheick Sidibe, Oumar Kantao, Iddo Dror and Abdou Fall at the Lessons in Working Towards Global Eradication of Peste des Petits Ruminants (PPR)
USAID Webinar, 2 December 2020.
One-Liner
BAIBYS™ develops an AI and robotics-based COMPLETELY AUTONOMOUS system for sperm selection for IVF, which will improve success rates, reduce birth defects, and raise clinics’ throughput.
The problem
According to the WHO guidelines, in a healthy man, 96% of the sperm cells are abnormal. Natural fertilization overcomes this problem by having millions of sperm cells compete on one egg through various selection processes such that only the best one wins. However, in IVF today, the injected sperm cells are selected arbitrarily. Thus, the natural sperm selection process is bypassed, leading to fewer successful pregnancies and more birth defects. A manual selection at high magnification was proposed, showing higher success rates and reduced birth defects (NEJM, 2001). Nevertheless, this manual procedure was not widely adopted since it was lengthy (3h vs. a few minutes), subjective and inconsistent, required extensive training, and was therefore expensive.
BAIBYS’ solution
BAIBYS’ system performs the same selection process, based on the same well-accepted criteria, COMPLETELY AUTONOMOUSLY, in a fraction of the time and cost of the current manual process. The user needs only to place a cartridge with the sperm sample into the console and press a button, and the system will autonomously identify the optimal cells and will robotically transfer them to a separate droplet in the cartridge. Eliminating the drawbacks of the manual process by making it fast, objective, consistent, without trained personnel, and affordable, would allow its use in every IVF cycle, improving success rates, and reducing birth defects, while raising the clinics’ throughput and reputation.
Impact
The system shall revolutionize the IVF process by reducing the financial and emotional crisis involved with it by saving failed IVF treatments, reducing the economic burden on health systems, raising IVF clinics throughput, making IVF more accessible globally, and most importantly, reducing birth defects and helping more families in having healthy babies.
Market
The global IVF market is estimated at $41B by 2026 and growing at >10% CAGR. With 5M IVF treatments in the world forecasted for 2026, at >$200 disposable cartridge cost, plus consoles and service sales, BAIBYS’ Total Addressable Market exceeds $1B.
Progress
After a seed round of $2M in Q1/2021 (mostly from angels who are international experts in andrology and fertility clinic owners) and completing a working prototype, we closed an additional $2M investment by an Israeli VC to lead a $3-4M round. The use of proceeds is to develop the product, conduct clinical trials, and get regulatory clearances. Our seed round investors participated in this round as well.
This document discusses artificial insemination (AI) in cattle. It defines AI as the introduction of semen into the oviduct or uterus by means other than sexual intercourse. The key advantages of AI include allowing desirable bull genetics to be passed on to more offspring more quickly, increasing bull usage efficiency, and reducing disease transmission. However, AI also has disadvantages like requiring good estrus detection and proper semen storage. The document describes common methods for collecting bull semen, either using an artificial vagina or electric stimulation. It also outlines the process for artificially inseminating cattle.
Precision Dairy Monitoring Opportunities and ChallengesJeffrey Bewley
This presentation provides an introduction to precision dairy monitoring. The wide range of opportunities for future dairy management are discussed. Then, the challenges of turning these dreams into reality are covered.
CATTLE MEDICAL DIAGNOSIS AND PREDICTION USING MACHINE LEARNINGIRJET Journal
This document describes a machine learning system to diagnose cattle health issues using images. The system uses cameras to capture images of the eyes, nose, and neck of cattle. These images are analyzed by a deep learning model trained on a dataset of healthy and infected cattle images. The model can detect common symptoms of respiratory diseases and output whether each body part appears healthy or infected. This automatic diagnosis system aims to improve cattle health monitoring compared to traditional manual methods, reducing costs for farmers and preventing disease outbreaks.
Slide 1: Title: EMERGING PEDIATRIC TECHNOLOGIES
By: Falakaara Saiyed
This presentation is about inventions in pediatric technologies.
Slide 2: Introduction
Children require specialized, compassionate and comprehensive care that supports every stage of their lives.
Innovation will help health care providers improve their care of pediatric patients
The Food and Drug Administration (FDA) has recognized the need for medical devices for the pediatric population and is responding with initiatives that support the development of safe and effective pediatric medical devices.
Slide 3: New innovative technology in the pediatric pipeline
Caring for the pediatric patient population — whether neonate, infant, child or adolescent — is complex.
FDA has implemented initiatives to increase the availability of pediatric medical devices, including identifying barriers to the development of pediatric devices and incorporating known information about other populations to support labeling of existing devices for pediatric indications.
As a result, new products indicated for pediatric patients will continue to be released and physician and patient awareness of the availability of these products will increase, leading to greater penetration of pediatric devices and driving market growth.
Slide 4: Currently Available Products
MyoPro 2 orthosis
Flourish pediatric esophageal atresia device
CGM G6
Pivo Needle-Free Blood Draw Technology
Owlet Smart Sock 2
Slide 10: Products in Clinical trials
Amplatzer duct occluder II AS
OtoNexus ultrasound device
Magnamosis magnetic compression anastomosis system
Dynamic spinal alignment brace
Slide 15: Products in Development
EOPatch
StethAid digital stethoscope
Perf-Fix tympanoplasty gel patch
Tabla pneumonia detector
Synthetic Muscle
REFERENCES
“Emerging Pediatric technologies”, Pediatric Technology Watch, Vizient, Vol.1.,2018.
“Emerging Pediatric technologies”, Pediatric Technology Watch, Vizient, Vol.1.,2018.
Leveraging existing clinical data for extrapolation to pediatric uses of medical devices; guidance for industry and Food and Drug Administration staff., 2016
Pediatric medical devices, Food and Drug Administration website.
Smith WM, Riddell F, Madon M, Gleva MJ. “Comparison of diagnostic value using a small, single channel, P-wave centric sternal ECG monitoring patch with a standard 3-lead Holter system over 24 hours”, Am Heart J., 2017;185:67-73.
learn about various methods of contraception , how to use various contraceptive devices and also learn about the hormonal and emergency contraceptives' methods. here is the detail of post coital methods to prevent pregnancy and terminal methods for sterilization.
This document discusses various contraceptive methods including barrier methods like condoms, diaphragms, and sponges as well as chemical and hormonal methods. It provides details on how each method works, effectiveness rates, advantages and disadvantages. Intrauterine devices (IUDs) are explained in depth, including types like copper IUDs and hormone-releasing IUDs. Hormonal contraceptives like combined oral contraceptive pills are also described.
Production and delivery of thermotolerant vaccine against peste des petits ru...ILRI
Presentation by Michel Dione, Cheick Sidibe, Oumar Kantao, Iddo Dror and Abdou Fall at the Lessons in Working Towards Global Eradication of Peste des Petits Ruminants (PPR)
USAID Webinar, 2 December 2020.
The document describes a new ovulation monitor called the iOvo that uses microfluidic chips to precisely detect ovulation through measuring changes in saliva conductivity, a reliable marker of ovulation. It aims to provide more accurate predictions of ovulation 4-7 days in advance compared to other methods, and can confirm ovulation occurred. The founders have invested their own money and are seeking additional funding of around 10 million euros over 5 years for development, testing, patenting and production ramp-up. They expect to sell over 125,000 units in 5 years, reaching break-even in the third year and generating a 28% return on investment. The global market for fertility and ovulation products is growing and valued at around $4 billion annually.
Sheep Cross Breeding and Reproductive Management Dr Talaat RefaatDr Talaat Refaat
الجمعية المصرية للأغنام والماعزوالحيوانات الصحراوية
EGYPTIAN ASSOCIATION OF SHEEP, GOATS & DESERT ANIMALS
1ST INTERNATIONAL CONFERENCE ON
ENHANCEMENT OF SMALL RUMINANT PRODUCTION
المؤتمر الدولى الأول لتنمية المجترات الصغيرة
7-9 فبراير 2006
SHEEP CROSS BREEDING AND REPRODUCTIVE MANAGEMENT AS TOOLS TO ENHANCE FLOCK PRODUCTIVITY
By
Dr TALAAT HARB M REFAAT
Eng ABDULLAH TALAAT REFAAT
(7-9 FEB, 2006)
Tamara Leahy is a PhD student studying ways to protect ram sperm during processing for freezing and sex-sorting. Her research aims to explore adding seminal plasma proteins to sperm to protect them from stress and damage during these processes. Her preliminary results suggest stress from sex-sorting causes oxidative damage to sperm, but adding seminal plasma proteins or antioxidants may help protect sperm fertility. While her studies show some success improving fertility, more work is needed to fully understand and address the variable responses observed related to factors like the season and timing of adding the protective proteins. She invites the reader to join her team to further this important work.
The document describes Zepto, an innovative disposable device for cataract surgery that uses precision-pulse technology to create an accurate and reproducible capsulotomy quickly and safely. It discusses studies showing Zepto results in minimal temperature change in the eye and stronger capsulotomy edges compared to other methods. The document also outlines Dymedex's market analysis projecting rapid adoption of Zepto as it addresses the needs of high-risk patient populations and its ease of use could make it the standard of care.
Automatic Estrus Detection System for Dairy Animalsidescitation
This paper deals with the new aid for detection of
Estrus (Heat) in dairy animals. As dairy Technology is
developing day by day, therefore reproductive performance of
dairy animals is major concern in dairy industry. This
Reproductive performance of dairy animals requires accurate
and regular Estrus detection. Estrus is nothing but a
behavioural symptom in mammals which indicate that female
is mated close to the ovulation. That’s why Timely detection
of estrus is the only solution to increase the fertility rate in
dairy animals. Failure to detect animal in estrus and breeding
animals which are not in estrus result in economic loss for
the owner because of extended calving interval and additional
semen expenses. Accurate Estrus detection gives idea about
proper timing of Artificial Insemination. So Estrus detection
is the key solution for effective growth in dairy technology.
During estrus period animal shows mounting behaviour,
increased physical activity and vaginal temperature of animal
is increased. So, in proposed technology, for the very first
time all these three signs are sensed by three sensors. The
signal from the sensors are given to the micro-controller, then
micro-controller process the data, display the data on LCD
screen as well as transfer all the data wirelessly to the Personal
computer (PC). PC runs a software module which display all
the data i.e. Animal name, number of mounting, physical
activity and vaginal temperature.
The document discusses how Hu-Friedy's Instrument Management System (IMS) can help dental practices improve efficiency, safety and organization. IMS provides cassettes that securely hold instruments throughout the cleaning and sterilization process. This reduces risks of injuries for staff while saving time compared to sorting loose instruments. IMS creates standardized workflows and allows assistants to remain with the dentist, improving patient care.
Quotes For College Essays. QuotesGram. Online assignment writing service.Lori Gilbert
Karlheinz Stockhausen was a German composer born in 1928 in Mödrath, Germany who went on to become one of the most important but also controversial composers of the 20th century. He developed new serial composition techniques in the 1950s and was a pioneer of electronic music, working with tape recorders and synthesizers to create groundbreaking works. Stockhausen had a profound influence on music in the later 20th century and challenged conventional notions of composition.
The document provides information about adipose-derived stem cells (ADSCs) and their clinical applications. It discusses that ADSCs can be easily harvested from fat using liposuction, cultured to increase cell numbers, and stored for future use. The document describes the multi-station system, which allows for harvesting fat, extracting ADSCs, and re-infusing the cells back into the patient in a single day in the operating room. It provides a step-by-step protocol for isolating ADSCs from fat tissue using the multi-station system involving liposuction, collagenase digestion, centrifugation, and washing steps. Potential clinical applications discussed include wound healing and breast reconstruction procedures.
The document summarizes the development of Invisa Bio over 10 weeks as they pivoted between different medical applications and solutions for their self-assembling medical device technology. They initially focused on manufacturing and delivery but shifted to leveraging drug delivery mechanisms. They considered applications in cardiology, neurology, and orthopedics before focusing on brain aneurysms based on feedback from physicians. The company incorporated, raised funding, and began shadowing doctors to further develop their technology to address unmet needs in difficult to reach areas.
0 A Work Project, presented as part of the requireme.docxoswald1horne84988
0
A Work Project, presented as part of the requirements for the Award of a Masters
Degree in Management from the Nova School of Business and Economics
Illumina:
The sustainability of its competitive position
Marta Gonçalves Serra #1467
A project carried out on the Strategy course, under the supervision of
Professor Luís Almeida Costa
December 2014
1
Acknowledgements
I would like to sincerely thank my supervisor, Professor Luís Almeida Costa, for his
patient guidance, availability and advice he has given me throughout the course of this
project. His mentorship was essential for the success of this work and ultimately, for my
overall and round learning. I would also like to thank Stathis Kanterakis, member of the
Bioinformatics team at Illumina (Cambridge, United Kingdom) for all the information he
shared with me regarding Illumina and the Sequencing Market. He also made possible the
opportunity to visit Illumina’s site at Cambridge and to directly meet employees. All his
contributions were essential to get a greater insight of the company. Additionally, I would
also like to thank my sister, Eva Serra, currently a PhD student at Cambridge and the
Wellcome Trust Sanger Institute, for her continued support in terms of scientific and
technical understanding of the human genome area.
2
Introduction
This work project presents a case study about the sustainability of the competitive position of
Illumina in the Sequencing Market. This is a very recent market, which is growing at
unexpected rates and is contributing for many scientific discoveries. Illumina is currently the
market leader in the sequencing devices manufacturing business and aims to become the
leading company from manufacturing to end-users. Traditionally, Illumina manufactures
instruments and pass them to the next intermediaries, which are service providers. However,
more recently Illumina has not only been manufacturing devices but also developing and
selling solutions directly to consumers. In such a dynamic and fast-growing market,
predicting the future of the industry is particularly difficult. Furthermore, firms face important
challenges when trying to sustain (and enhance) their competitive position. This is precisely
the challenge that Illumina is facing. Since the objective was to conduct and in depth analyze
the competitive situation of a company – Illumina –, the elaboration of a case study seemed to
be the most appropriate approach.
The work project is composed by a case study and a case discussion. The case study starts
with an overview of the Sequencing Market. We then describe Illumina’s positioning in terms
of market segments and products offered. After that, we present some facts about Illumina’s
performance. Finally, we leave some questions for discussion. The case discussion will focus
on the value creation potential of Illumina and the sustainability .
Modified Child Rescue System against Open Borewellijtsrd
1. The document describes a modified child rescue system designed to safely rescue children trapped in open borewells within a short period of time.
2. The system uses additional components like adjustable arms, a digital integrated camera for monitoring the child, audio communication, rope, and pulley to improve rescue operations.
3. The system is portable and can move inside the borewell to reach the child, attach a harness, and bring the child to safety, avoiding the need to dig a parallel pit.
Dr. Mark Allen - Present & Future: Bovine Genetic & Reproductive TechnologiesJohn Blue
Present & Future: Bovine Genetic & Reproductive Technologies - Dr. Mark Allan, Director Marketing and Genomics, Trans Ova Genetics, from the 2014 NIAA Annual Conference titled 'The Precautionary Principle: How Agriculture Will Thrive', March 31 - April 2, 2014, Omaha, NE, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2014_niaa_how_animal_agriculture_will_thrive
Technology will save our minds and bodiesmark_power
The document discusses several new medical technologies from 2012 including:
1) An origami-inspired paper sensor that can detect diseases like malaria and HIV for 10 cents per test.
2) The I-BESS system, a body suit and vehicle sensors that record blast impacts to help diagnose soldier injuries.
3) An instrument that performs tissue sealing and cutting to help surgeons reduce operating time.
4) Microrobots designed to swim inside the body and deliver targeted drug therapies.
Genentech was the first biotech company founded in 1976 with the goal of using recombinant DNA technology to develop new drugs. It successfully transferred genes between species and established a new business model in the pharmaceutical industry. While Genentech initially struggled to profit from its technology, by the late 1980s it began showing promising results by altering its business model to focus on areas like oncology, immunology, and neuroscience. It became the first biotech company to go public and bring a genetically engineered drug to market.
The most advanced ivf and fertility centres 2018insightscare
With the need for high standards of IVF treatment, we bring the “The 10 Most Advanced IVF and Fertility Centers 2018.” These fertility clinics are providing contemporary paraphernalia to meet all the demands the IVF and Fertility vertical poses.
The document discusses the ethical theory of ethical egoism. It defines ethical egoism as a theory where people do things or react based on what is in their best interest. The motivation behind ethical egoism depends on how a situation will impact one's self-interest. The paper aims to defend the idea that babies are born with the morality of ethical egoism, as ethical egoism focuses solely on benefiting the individual. Ethical egoism prioritizes self-interest over helping others unless it provides personal benefit.
The document discusses the ethical theory of ethical egoism. It defines ethical egoism as a theory where people do things or react based on what is in their best interest. The motivation behind ethical egoism depends on how a situation will impact one's self-interest. The paper aims to defend the idea that babies are born with the morality of ethical egoism, as ethical egoism focuses solely on benefiting the individual. Ethical egoism prioritizes self-interest over helping others unless it provides personal benefit.
The document describes medical training products from Modiezham Sdn Bhd and 3B Scientific. It includes details on a basic life support simulator called Basic Billy for realistic CPR training. It also describes a new ultrasound-guided sclerotherapy simulator for training varicose vein procedures. The document provides an overview of the company's products across various medical specialties including anatomy models, medical techniques trainers, software, and wall charts.
Automation techniques have been increasingly used in livestock production to reduce labor needs. This includes automatic identification of animals using RFID tags, GPS tracking, or retinal/muzzle scanning. Other automated processes discussed are feeding, milking, estrus detection through activity/hormone monitoring, birth detection, online herd management, and barn cleaning/environment control. The document concludes that while automation increases production and efficiency, it also increases costs, so is best for large commercial farms.
The document describes a new ovulation monitor called the iOvo that uses microfluidic chips to precisely detect ovulation through measuring changes in saliva conductivity, a reliable marker of ovulation. It aims to provide more accurate predictions of ovulation 4-7 days in advance compared to other methods, and can confirm ovulation occurred. The founders have invested their own money and are seeking additional funding of around 10 million euros over 5 years for development, testing, patenting and production ramp-up. They expect to sell over 125,000 units in 5 years, reaching break-even in the third year and generating a 28% return on investment. The global market for fertility and ovulation products is growing and valued at around $4 billion annually.
Sheep Cross Breeding and Reproductive Management Dr Talaat RefaatDr Talaat Refaat
الجمعية المصرية للأغنام والماعزوالحيوانات الصحراوية
EGYPTIAN ASSOCIATION OF SHEEP, GOATS & DESERT ANIMALS
1ST INTERNATIONAL CONFERENCE ON
ENHANCEMENT OF SMALL RUMINANT PRODUCTION
المؤتمر الدولى الأول لتنمية المجترات الصغيرة
7-9 فبراير 2006
SHEEP CROSS BREEDING AND REPRODUCTIVE MANAGEMENT AS TOOLS TO ENHANCE FLOCK PRODUCTIVITY
By
Dr TALAAT HARB M REFAAT
Eng ABDULLAH TALAAT REFAAT
(7-9 FEB, 2006)
Tamara Leahy is a PhD student studying ways to protect ram sperm during processing for freezing and sex-sorting. Her research aims to explore adding seminal plasma proteins to sperm to protect them from stress and damage during these processes. Her preliminary results suggest stress from sex-sorting causes oxidative damage to sperm, but adding seminal plasma proteins or antioxidants may help protect sperm fertility. While her studies show some success improving fertility, more work is needed to fully understand and address the variable responses observed related to factors like the season and timing of adding the protective proteins. She invites the reader to join her team to further this important work.
The document describes Zepto, an innovative disposable device for cataract surgery that uses precision-pulse technology to create an accurate and reproducible capsulotomy quickly and safely. It discusses studies showing Zepto results in minimal temperature change in the eye and stronger capsulotomy edges compared to other methods. The document also outlines Dymedex's market analysis projecting rapid adoption of Zepto as it addresses the needs of high-risk patient populations and its ease of use could make it the standard of care.
Automatic Estrus Detection System for Dairy Animalsidescitation
This paper deals with the new aid for detection of
Estrus (Heat) in dairy animals. As dairy Technology is
developing day by day, therefore reproductive performance of
dairy animals is major concern in dairy industry. This
Reproductive performance of dairy animals requires accurate
and regular Estrus detection. Estrus is nothing but a
behavioural symptom in mammals which indicate that female
is mated close to the ovulation. That’s why Timely detection
of estrus is the only solution to increase the fertility rate in
dairy animals. Failure to detect animal in estrus and breeding
animals which are not in estrus result in economic loss for
the owner because of extended calving interval and additional
semen expenses. Accurate Estrus detection gives idea about
proper timing of Artificial Insemination. So Estrus detection
is the key solution for effective growth in dairy technology.
During estrus period animal shows mounting behaviour,
increased physical activity and vaginal temperature of animal
is increased. So, in proposed technology, for the very first
time all these three signs are sensed by three sensors. The
signal from the sensors are given to the micro-controller, then
micro-controller process the data, display the data on LCD
screen as well as transfer all the data wirelessly to the Personal
computer (PC). PC runs a software module which display all
the data i.e. Animal name, number of mounting, physical
activity and vaginal temperature.
The document discusses how Hu-Friedy's Instrument Management System (IMS) can help dental practices improve efficiency, safety and organization. IMS provides cassettes that securely hold instruments throughout the cleaning and sterilization process. This reduces risks of injuries for staff while saving time compared to sorting loose instruments. IMS creates standardized workflows and allows assistants to remain with the dentist, improving patient care.
Quotes For College Essays. QuotesGram. Online assignment writing service.Lori Gilbert
Karlheinz Stockhausen was a German composer born in 1928 in Mödrath, Germany who went on to become one of the most important but also controversial composers of the 20th century. He developed new serial composition techniques in the 1950s and was a pioneer of electronic music, working with tape recorders and synthesizers to create groundbreaking works. Stockhausen had a profound influence on music in the later 20th century and challenged conventional notions of composition.
The document provides information about adipose-derived stem cells (ADSCs) and their clinical applications. It discusses that ADSCs can be easily harvested from fat using liposuction, cultured to increase cell numbers, and stored for future use. The document describes the multi-station system, which allows for harvesting fat, extracting ADSCs, and re-infusing the cells back into the patient in a single day in the operating room. It provides a step-by-step protocol for isolating ADSCs from fat tissue using the multi-station system involving liposuction, collagenase digestion, centrifugation, and washing steps. Potential clinical applications discussed include wound healing and breast reconstruction procedures.
The document summarizes the development of Invisa Bio over 10 weeks as they pivoted between different medical applications and solutions for their self-assembling medical device technology. They initially focused on manufacturing and delivery but shifted to leveraging drug delivery mechanisms. They considered applications in cardiology, neurology, and orthopedics before focusing on brain aneurysms based on feedback from physicians. The company incorporated, raised funding, and began shadowing doctors to further develop their technology to address unmet needs in difficult to reach areas.
0 A Work Project, presented as part of the requireme.docxoswald1horne84988
0
A Work Project, presented as part of the requirements for the Award of a Masters
Degree in Management from the Nova School of Business and Economics
Illumina:
The sustainability of its competitive position
Marta Gonçalves Serra #1467
A project carried out on the Strategy course, under the supervision of
Professor Luís Almeida Costa
December 2014
1
Acknowledgements
I would like to sincerely thank my supervisor, Professor Luís Almeida Costa, for his
patient guidance, availability and advice he has given me throughout the course of this
project. His mentorship was essential for the success of this work and ultimately, for my
overall and round learning. I would also like to thank Stathis Kanterakis, member of the
Bioinformatics team at Illumina (Cambridge, United Kingdom) for all the information he
shared with me regarding Illumina and the Sequencing Market. He also made possible the
opportunity to visit Illumina’s site at Cambridge and to directly meet employees. All his
contributions were essential to get a greater insight of the company. Additionally, I would
also like to thank my sister, Eva Serra, currently a PhD student at Cambridge and the
Wellcome Trust Sanger Institute, for her continued support in terms of scientific and
technical understanding of the human genome area.
2
Introduction
This work project presents a case study about the sustainability of the competitive position of
Illumina in the Sequencing Market. This is a very recent market, which is growing at
unexpected rates and is contributing for many scientific discoveries. Illumina is currently the
market leader in the sequencing devices manufacturing business and aims to become the
leading company from manufacturing to end-users. Traditionally, Illumina manufactures
instruments and pass them to the next intermediaries, which are service providers. However,
more recently Illumina has not only been manufacturing devices but also developing and
selling solutions directly to consumers. In such a dynamic and fast-growing market,
predicting the future of the industry is particularly difficult. Furthermore, firms face important
challenges when trying to sustain (and enhance) their competitive position. This is precisely
the challenge that Illumina is facing. Since the objective was to conduct and in depth analyze
the competitive situation of a company – Illumina –, the elaboration of a case study seemed to
be the most appropriate approach.
The work project is composed by a case study and a case discussion. The case study starts
with an overview of the Sequencing Market. We then describe Illumina’s positioning in terms
of market segments and products offered. After that, we present some facts about Illumina’s
performance. Finally, we leave some questions for discussion. The case discussion will focus
on the value creation potential of Illumina and the sustainability .
Modified Child Rescue System against Open Borewellijtsrd
1. The document describes a modified child rescue system designed to safely rescue children trapped in open borewells within a short period of time.
2. The system uses additional components like adjustable arms, a digital integrated camera for monitoring the child, audio communication, rope, and pulley to improve rescue operations.
3. The system is portable and can move inside the borewell to reach the child, attach a harness, and bring the child to safety, avoiding the need to dig a parallel pit.
Dr. Mark Allen - Present & Future: Bovine Genetic & Reproductive TechnologiesJohn Blue
Present & Future: Bovine Genetic & Reproductive Technologies - Dr. Mark Allan, Director Marketing and Genomics, Trans Ova Genetics, from the 2014 NIAA Annual Conference titled 'The Precautionary Principle: How Agriculture Will Thrive', March 31 - April 2, 2014, Omaha, NE, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2014_niaa_how_animal_agriculture_will_thrive
Technology will save our minds and bodiesmark_power
The document discusses several new medical technologies from 2012 including:
1) An origami-inspired paper sensor that can detect diseases like malaria and HIV for 10 cents per test.
2) The I-BESS system, a body suit and vehicle sensors that record blast impacts to help diagnose soldier injuries.
3) An instrument that performs tissue sealing and cutting to help surgeons reduce operating time.
4) Microrobots designed to swim inside the body and deliver targeted drug therapies.
Genentech was the first biotech company founded in 1976 with the goal of using recombinant DNA technology to develop new drugs. It successfully transferred genes between species and established a new business model in the pharmaceutical industry. While Genentech initially struggled to profit from its technology, by the late 1980s it began showing promising results by altering its business model to focus on areas like oncology, immunology, and neuroscience. It became the first biotech company to go public and bring a genetically engineered drug to market.
The most advanced ivf and fertility centres 2018insightscare
With the need for high standards of IVF treatment, we bring the “The 10 Most Advanced IVF and Fertility Centers 2018.” These fertility clinics are providing contemporary paraphernalia to meet all the demands the IVF and Fertility vertical poses.
The document discusses the ethical theory of ethical egoism. It defines ethical egoism as a theory where people do things or react based on what is in their best interest. The motivation behind ethical egoism depends on how a situation will impact one's self-interest. The paper aims to defend the idea that babies are born with the morality of ethical egoism, as ethical egoism focuses solely on benefiting the individual. Ethical egoism prioritizes self-interest over helping others unless it provides personal benefit.
The document discusses the ethical theory of ethical egoism. It defines ethical egoism as a theory where people do things or react based on what is in their best interest. The motivation behind ethical egoism depends on how a situation will impact one's self-interest. The paper aims to defend the idea that babies are born with the morality of ethical egoism, as ethical egoism focuses solely on benefiting the individual. Ethical egoism prioritizes self-interest over helping others unless it provides personal benefit.
The document describes medical training products from Modiezham Sdn Bhd and 3B Scientific. It includes details on a basic life support simulator called Basic Billy for realistic CPR training. It also describes a new ultrasound-guided sclerotherapy simulator for training varicose vein procedures. The document provides an overview of the company's products across various medical specialties including anatomy models, medical techniques trainers, software, and wall charts.
Automation techniques have been increasingly used in livestock production to reduce labor needs. This includes automatic identification of animals using RFID tags, GPS tracking, or retinal/muzzle scanning. Other automated processes discussed are feeding, milking, estrus detection through activity/hormone monitoring, birth detection, online herd management, and barn cleaning/environment control. The document concludes that while automation increases production and efficiency, it also increases costs, so is best for large commercial farms.
1. AI, IUI, DIUI,
WHICH ONE IS RIGHT FOR MY FARM?
Did you ever think an
Artificial Insemination
device could give you a
5,000% + return on your
investment (ROI)?
Decades ago, a novel approach to pig breeding
was introduced that is nowadays status quo. When the
new technology was first introduced, it took special
people, leaders in the industry, and people with a vision
to take a risk and “change” the way they had always
bred in the past. Yes, we are talking about “traditional
cervical artificial insemination” (or AI).
Although the advantages were many, there
were skeptics that refused to adapt to the new
technology, regardless of its benefits and additional
profit it could create for the farm.
Change is very difficult for many people to
accept at times; and today’s options pose even more
considerations. With that said, let’s begin by defining
the acronyms AI, IUI, DIUI, and a hybrid of IUI and DIUI
(Absolute’s AMG Series ™).
AI, or traditional Artificial Insemination simply
uses a tubular pipette with a foam tip and usually a soft
rubber end to accept a variety of semen containers.
This is a cervical insemination; meaning that the foam
tip is lodged into the beginning of the cervix, and the
sow or gilt draw the semen from the bottle, flat pack, or
tube via contractions when she is stimulated. Usually,
there is a boar present, and/or a technician that rubs
the flanks, administers back pressure and performs
other types of stimulation to assist (or bring on) the
animal’s contractions.
IUI, or “Intra-Uterine Insemination” generally
consists of a relatively small diameter rigid tube, inside
a regular traditional pipette. This smaller tube is gently
pushed through the cervix and directly into the uterus.
While there can be advantages to this method,
it has been relatively slow to catch on due to the
potential of hurting the animal by scraping or
puncturing delicate tissues in the reproductive tract.
These dangers can be magnified since this type of
pipette also collects a small amount of bacteria laden
matter when it is threaded through the cervix. Even
when the process is performed by highly trained
technicians or Veterinarians, there is no way of
keeping this little plug of unmentionables out of the
reproductive tract.
The cervix’s primary role is to keep bacteria and
contaminants from entering the uterus and uterine
horns (the animal’s reproductive tract). Once this
substance enters the uterus, the animals are more
prone to infections, abortions, smaller litter sizes, and
lesser farrowing percentages.
Next we have the DIUI, or Deep Intra-Uterine
Insemination. This is a very controversial procedure;
one that uses a thin flexible tubular pipette that is
approximately 1.7 meters in length. The extreme length
of this tube allows it to be inserted all the way to the
UTJ (uteral tubal junction) where its design allows it to
place very small amounts of semen (albeit in only one
horn).
The following link, submitted by the CENTER
FOR ADVANCED TECHNOLOGIES IN ANIMAL GENETICS
AND REPRODUCTION (REROGEN), FACULTY OF
VETERINARY SCIENCE, THE UNIVERSITY OF SYDNEY,
NSW 2006, AUSTRALIA, explains the process in greater
detail.
http://www.ncbi.nlm.nih.gov/pubmed/17275224
“Investigation of the uterine lining after
insertion of the DIUI catheter revealed
evidence of bleeding, warranting further
investigation of the viability of widespread
use of the Firflex® catheter, despite the
promising fertility achieved here with low
doses of spermatozoa.”
2. The presentation immediately below was
produced by Dr. Don Levis, The Ohio Pork Industry
Center, The Ohio State University, and Swine Veterinary
Center; among others. Slides 28-32 relate to the AMG
Series™ catheter when it was called the Absolute
Catheter (click on image to view .pdf file);
and slides 33-35 are specific to the FirFlex® DIUI model
of catheter.
Needless to say, this method of breeding might
work in clinical trials performed by elite doctors in their
trade; but this technology is not ready for mainstream
use in production farms. Going to such extremes to save
a few milliliters of semen, hardly justifies the risks and
difficulties of integrating this technology into main-
stream production farms.
There is a better way! Absolute Swine
Insemination Co., LLC (ASIC) combines the performance
of DIUI and the relative safety of traditional cervical
inseminations with their hydraulic AMG Series™
catheters; and they do it safely and effectively in “both”
horns at the same time.
ASIC’s patented technology has a very
flexible membrane hiding inside their specially
designed plastic catheter. This membrane moves
forward when a technician squeezes on the semen
tube, flat pack, bottle, or any semen container in the
market today. Since the AMG™ pipette’s membrane
turn itself inside out while moving forward, the
aforementioned plug of bacteria is actually re-deposited
at the very beginning of the cervix. The only substance
entering the reproductive tract of your animals is what
is inside the semen container.
Immediately below is a picture of a parity 4
sow’s reproductive tract. This animal was “injected”
with a dye substance using the AMG Series™ of
catheters. Immediately after injecting the dye, the
animal was culled and her reproductive tract was
removed and opened. As you can see, the dye
advanced up both horns to the UTJ instantaneously
without any injury or risk to the animal
Click on any of the graphics to see a full size version.
The next picture is also of a parity 4 sow bred
using a traditional foam tip pipette. As you can see, the
majority of semen is trapped in the cervix and some has
advanced a short distance up the horns.The semen still
has a long way to travel prior to reaching the UTJ
awaiting ovulation; but more importantly, most of the
semen will die along this journey due to Phagocytosis.
Will there be welfare issues?
Don G. Levis, PhD
3. A full explanation of the Transport and Loss of
Boar Spermatozoa in the Reproductive Tract of the Sow,
published by the Journal of Animal Science; by N. L.
First, R. E. Short, J. B. Peters and F. W. Stratman can be
read at http://jas.fass.org/content/27/4/1037.full.pdf
With that said, it is essential the semen reaches
the UTJ in the shortest amount of time possible. The
article link above references the time span being
anywhere from 10 minutes to 5 hours; the jury is not
always in agreement in these matters. In the trials ASIC
performed, the semen reached the UTJ and was in safe
storage virtually instantaneously. This is a very
important aspect of ASIC’s success. Filling the UTJ with
fresh viable semen gives you much greater odds at
fertilizing the largest number of oocytes during
ovulation. It is simple common sense; isn’t it? The
greater the number of strong viable semen that have
not undergone the death march through the horns is
undoubtedly going to give you better performance.
The AMG Series™ of catheters are much more
than a hybrid artificial insemination tool. They are tools
that when used properly can offer incredible profits for
your farms bottom line. This technology is not for
everyone… it requires ambitious people with a positive
attitude that believe good performance is not always
good enough! In order to monitor and calculate profits,
farms and personnel need to maintain good records and
documentation; they also need people willing to study
understand and believe in ASIC’s suggested timing
protocols.
One such gentleman that has these qualities
and welcomed change is Mac Magee of Commercial
Concepts AI, Inc. Mac has taken 4 units to outstanding
new heights; and he has been considerate enough to
share the statistics with us for this article.
Mr. Mac Magee of Commercial Concepts AI, Inc
Mac has agreed to validate all of the Commercial
Concepts AI, Inc. information and can be reached by
email only.
mmagee@commercialconceptsai.com
Please click on any chart or spreadsheet (a full screen
file will open) to see the improvements accomplished
using the AMG Series™ with ASIC’s recommended
insemination timing protocols.
Before and after performance on SOWs.
Collectively, the SOWs serviced by
ASIC’s technology provided
$424,944.00 USD in EXTRA ANNUAL
PROFIT. The ROI in the group ranged
from a low of 498.16%
with the highest being 4866.29%
4. Before and after performance on GILTs
Collectively, the GILTs serviced by
ASIC’s technology provided
$252,716.00 USD in EXTRA ANNUAL
PROFIT. The ROI in this group ranged
from a low of 661.96%
with the highest being 5,430.87%
Performance like this is not achieved by a
magic wand catheter; it requires good
management, accurate heat detection, genetics,
nutrition, vaccination programs, accurate record
keeping, and of course good technicians.
This is where the second phase of the AMG
Series™ both differs and excels over conventional
AI methods. ASIC’s timing protocols are based on
individual animal’s physiology; there is no blanket
system where you breed all animals on the 4th or
5th day post weaning… and the animals are also
heat checked and bred twice per day (AM & PM).
Many of you at this stage will simply say we
can’t do that, we don’t have the crew or the time
(this is where the positive attitude plays its role).
When you can breed your animals on an average of
one minute or less per service, a great deal of time
is provided for you, simply due to the speed of
servicing. Your crew will have more time to spend
accurately heat detecting and all the other chores
at hand that consumed the time necessary to heat
detect and breed twice a day before.
The first part of any successful breeding
program is of course, heat detection. If your people
are breeding animals too early or too late, your
results will be meager. If you breed like many
examples shown in a downloadable PowerPoint
Presentation a little further in this article, you will
easily see how important the heat detection and
timing actually is.
The first slide you below depicts our
recommended protocols which overlap ovulation
almost perfectly. Heat detection was performed
twice per day as well as breeding. The green bars
are the semen doses and the purple portion of the
bar is ovulation.
Please notice how the duration of estrus
shortens everyday post weaning. Both estrus and
ovulation cycles become shorter as the days after
weaning become greater.
The next slide represents the same graph,
with the only difference being this group was heat
checked only once per day. We use green, yellow,
and red just like traffic lights. Green is a go, yellow
is use caution, and red means stop; you will either
waste your dose of semen or you could abort the
animal if she conceived during the first
insemination and no longer was in estrus and/or
ovulating.
5. The next slide shows comparison in accuracy
between twice per day heat checking and once per
day
The Insemination Timing Suggestions
PowerPoint presentation can now be viewed on
any Windows based computer. There is no need for
you to have PowerPoint installed. You will be
amazed how some very common and accepted
procedures end up being so wrong. It is hard to
imagine or explain in words; therefore the slides
are animated to help make our point.
We could write a book about our
procedures and benefits your farm can achieve.
Actually, we have done better than that. You can
now view our entire tutorial presentation online
anytime, anywhere without signing up. To view our
latest presentation click on the following image.
Summary of Performance Improvements
*start up