This chapter discusses midlife and menopause in women. It defines midlife as ages 45-65, a time of emotional, social, and physical changes for women, including menopause. Menopause is defined as the end of monthly menstrual periods, and is usually around age 51 but can vary. During this transition, women experience hormonal changes, social role changes as children leave home, and increased health risks. The chapter outlines common symptoms, health concerns, and lifestyle strategies including exercise that can help manage this period.