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Case study in Genomics &
Personalized Medicine
Rapid prototyping, iterative development &
continuous improvement
Sanika Bhide, Ph.D
Senior Lead Business Analyst
Tieto, Healthcare and Welfare Solutions
sanika.bhide@tieto.com
#APGI2018 Conference, 18th May 2018, Agility Beyond IT
Public
About Tieto
Intro to myself
23-05-2018
2
© Tieto Corporation
Public
Outline
• Quick Quiz
• Commonalities in Scientific Research and Agile
• Capsule on Genomics and
• Case studies
• Rapid prototyping : Human Genome project vs. Next generation
sequencing
• Data Agility for Genomic Data warehouse
• Personalized medicine and Tietos’ contributions
• Take home bullets
3
© Tieto Corporation
Public
4
Aristotle
Philosopher and scientist
384–322 BC
Fire your neurons…...
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© Tieto Corporation
Public
5
• Observe phenomenon
• Gather data
• Discover patterns
• Create generative models of events
Why Aristotle?
• Rhetoric theory
• Argument and persuasion
• Three pillars of a stellar user story
© Tieto Corporation
Public
6
Complex problem
Business
Value
Business
Value
Hypothesis driven Scientific approach
Sprint 0: Define PBL / XP’s Planning game
Prioritize tasks based on business impact/
value, cost and complexity
Plan stories with Acceptance test criterion (If
the code runs then then outputs should pass
test T1 and T2)
Maintain collection f tests as Test cases / test
suites to verify results of different use cases /
scenarios
If tests fail in certain scenarios, tweak / iterate
and construct new Acceptance tests and
retest
Agile – XP approach
NoveltyNovelty
Everything starts with a…..
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© Tieto Corporation
Public
“DNA is like a computer program but far, far more advanced than any
software ever created.”
7
Digital representation of the human genome in New York City in 2001
(Image courtesy: Ker Than, for National Geographic News)
Bill Gates
© Tieto Corporation
Public
8
• Genetic code
• Software code
Life…..Code…..Software
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© Tieto Corporation
Public
9
Human Genome Science timeline
© Tieto Corporation
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10
Genome sequencing technology timeline
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© Tieto Corporation
Public
11
© Tieto Corporation
Public
12
Agile Rapid Incremental
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© Tieto Corporation
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13
PROBLEM:
• Data size
• Data complexity
• Data release
RESULT:
• 20% reduction in Data
preparation time
• 70% decrease in DB
storage footprint
• 15% faster and frequent
releases
SOLUTION:
• Data virtualization
• Cloud environment
• DevOps
Public
Question break
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© Tieto Corporation
Public
15
© Tieto Corporation
Public
16
• Side effects
• Low efficacy of treatment
• New symptoms
• Need for higher dosage
• Poor treatment outcome
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© Tieto Corporation
Public
17
Diverse subtypes of
Patients with Blood
Pressure
DNA analysis to identify rare
genomic variations
Personalized medication
recommended as per genomic
profile
© Tieto Corporation
Public
18
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© Tieto Corporation
Public
19
Public
Take home….
• Science is different…..but very similar to S/W development
• When in doubt, use Aristotle’s Rhetoric to resolve team and story level
issues
• There is always room for Agile in every Non-IT field……it just a matter
of aligning
• Using Agile transformations, Tieto is leading the way for Lab solutions
in areas like Genomics and Personalized diagnostics
23-05-2018
11
Public
Sanika Bhide
Senior Lead Business Analyst
Tieto, ZSP Industry Solutions / ZSPHH Healthcare and Welfare Solutions
sanika.bhide@tieto.com

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Agile beyond it case study sanika bhide

  • 1. 23-05-2018 1 Public Case study in Genomics & Personalized Medicine Rapid prototyping, iterative development & continuous improvement Sanika Bhide, Ph.D Senior Lead Business Analyst Tieto, Healthcare and Welfare Solutions sanika.bhide@tieto.com #APGI2018 Conference, 18th May 2018, Agility Beyond IT Public About Tieto Intro to myself
  • 2. 23-05-2018 2 © Tieto Corporation Public Outline • Quick Quiz • Commonalities in Scientific Research and Agile • Capsule on Genomics and • Case studies • Rapid prototyping : Human Genome project vs. Next generation sequencing • Data Agility for Genomic Data warehouse • Personalized medicine and Tietos’ contributions • Take home bullets 3 © Tieto Corporation Public 4 Aristotle Philosopher and scientist 384–322 BC Fire your neurons…...
  • 3. 23-05-2018 3 © Tieto Corporation Public 5 • Observe phenomenon • Gather data • Discover patterns • Create generative models of events Why Aristotle? • Rhetoric theory • Argument and persuasion • Three pillars of a stellar user story © Tieto Corporation Public 6 Complex problem Business Value Business Value Hypothesis driven Scientific approach Sprint 0: Define PBL / XP’s Planning game Prioritize tasks based on business impact/ value, cost and complexity Plan stories with Acceptance test criterion (If the code runs then then outputs should pass test T1 and T2) Maintain collection f tests as Test cases / test suites to verify results of different use cases / scenarios If tests fail in certain scenarios, tweak / iterate and construct new Acceptance tests and retest Agile – XP approach NoveltyNovelty Everything starts with a…..
  • 4. 23-05-2018 4 © Tieto Corporation Public “DNA is like a computer program but far, far more advanced than any software ever created.” 7 Digital representation of the human genome in New York City in 2001 (Image courtesy: Ker Than, for National Geographic News) Bill Gates © Tieto Corporation Public 8 • Genetic code • Software code Life…..Code…..Software
  • 5. 23-05-2018 5 © Tieto Corporation Public 9 Human Genome Science timeline © Tieto Corporation Public 10 Genome sequencing technology timeline
  • 6. 23-05-2018 6 © Tieto Corporation Public 11 © Tieto Corporation Public 12 Agile Rapid Incremental
  • 7. 23-05-2018 7 © Tieto Corporation Public 13 PROBLEM: • Data size • Data complexity • Data release RESULT: • 20% reduction in Data preparation time • 70% decrease in DB storage footprint • 15% faster and frequent releases SOLUTION: • Data virtualization • Cloud environment • DevOps Public Question break
  • 8. 23-05-2018 8 © Tieto Corporation Public 15 © Tieto Corporation Public 16 • Side effects • Low efficacy of treatment • New symptoms • Need for higher dosage • Poor treatment outcome
  • 9. 23-05-2018 9 © Tieto Corporation Public 17 Diverse subtypes of Patients with Blood Pressure DNA analysis to identify rare genomic variations Personalized medication recommended as per genomic profile © Tieto Corporation Public 18
  • 10. 23-05-2018 10 © Tieto Corporation Public 19 Public Take home…. • Science is different…..but very similar to S/W development • When in doubt, use Aristotle’s Rhetoric to resolve team and story level issues • There is always room for Agile in every Non-IT field……it just a matter of aligning • Using Agile transformations, Tieto is leading the way for Lab solutions in areas like Genomics and Personalized diagnostics
  • 11. 23-05-2018 11 Public Sanika Bhide Senior Lead Business Analyst Tieto, ZSP Industry Solutions / ZSPHH Healthcare and Welfare Solutions sanika.bhide@tieto.com