This document provides instructions for an assignment comparing and contrasting two clinical settings and their use of health informatics. Students are to: 1) Select two diverse clinical settings like the ED vs ICU and analyze the different data, information, knowledge and decision support needs. 2) Consider how the "four expanding rings of information" like EMRs and regional health information networks would impact system design. 3) Justify creating a shared clinical system from ethical, legal and policy viewpoints and outline an implementation plan and workflow. 4) Evaluate the role of a master's prepared nurse informaticist after implementation.