Acoustic neuroma is a benign tumor of the eighth cranial nerve. The document discusses the definition, histopathology, etiology, classification, clinical features, investigations, differential diagnosis, and management of acoustic neuroma. The key signs and symptoms include progressive hearing loss, tinnitzus, imbalance, and cranial nerve involvement including facial numbness. MRI with gadolinium is the gold standard for diagnosis. Treatment options include surgical removal via middle cranial fossa, translabyrinthine, or suboccipital approaches or stereotactic radiotherapy using gamma knife or cyber knife.
Slides prepared and compiled by highly experienced ENT teacher, Dr. Krishna Koirala from Nepal , for teaching undergraduate and postgraduate ENT students in the field of otorhinolaryngology.
A clear and concise explanation of the basic concepts in the subject matter concerned.
He is the Head of department with a sound knowledge in the field of ENT to teach both undergraduate and postgraduate ENT students
Slides prepared and compiled by highly experienced ENT teacher, Dr. Krishna Koirala from Nepal , for teaching undergraduate and postgraduate ENT students in the field of otorhinolaryngology.
A clear and concise explanation of the basic concepts in the subject matter concerned.
He is the Head of department with a sound knowledge in the field of ENT to teach both undergraduate and postgraduate ENT students
In this presentation we will dscuss the imp imaging features of Posterior fossa tumors in pediatric age group.
Medulloblastoma
Pilocytic Astrocytoma
Ependymoma
Brainstem Glioma
Schwanoma
Meningioma
Epidermoid Cyst
Arachnoid Cyst
Acoustic neuroma- tells about anatomy. etiology, pathophysiology, clinical features, investigations and management of the very called disease related to ear acoustic neuroma.
Please find the power point on Brain tumors (Acoustic Neuroma). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
A 12 year boy presented with slow growing lateral neck mass beneath left sternocleidomastoid muscle. Preoperative diagnosis was uncertain so tumor was excised and it came out to be schwannoma.
In this presentation we will dscuss the imp imaging features of Posterior fossa tumors in pediatric age group.
Medulloblastoma
Pilocytic Astrocytoma
Ependymoma
Brainstem Glioma
Schwanoma
Meningioma
Epidermoid Cyst
Arachnoid Cyst
Acoustic neuroma- tells about anatomy. etiology, pathophysiology, clinical features, investigations and management of the very called disease related to ear acoustic neuroma.
Please find the power point on Brain tumors (Acoustic Neuroma). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
A 12 year boy presented with slow growing lateral neck mass beneath left sternocleidomastoid muscle. Preoperative diagnosis was uncertain so tumor was excised and it came out to be schwannoma.
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Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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2 Case Reports of Gastric Ultrasound
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
6. Origin & Growth
• Origin:
Schwann Cells of Vestibular Nerve, rarely from
cochlear nerve
• Growth: (slow)
Causes widening and erosion of the canal and
appears in the CP angle
Anterosuperior growth: 5th
Inferior: 9th , 10th & 11th
Later stages: displacement of brainstem, pressure on
cerebellum and raised intracranial tension
9. Clinical Features
• Age : 40-60 years
• Sex: M=F
• Symptoms:
1. Progressive unilateral SNHL
2. Tinnitus
3. Marked difficulty in understanding speech
4. Imbalance/ Unsteadiness
5. Vertigo
6. Sudden Hearing loss
7. Fullness in the ear
10. Cranial Nerve Involvement
1. 5th nerve: EARLIEST
Reduced cornea sensitivity, paraesthesia of face
Involvement indicates : tumour size = 2.5cm &
occupies CP angle
2. 9th & 10th : dysphagia & hoarseness due to
palatal, pharyngeal, laryngeal paralysis
3. Other cranial nerves: affected only when tumour
size is very large
11. Cranial Nerve Involvement
Facial nerve:
• Sensory fibres are affected early.
• Hitzelberger’s sign : Hypoaesthesia of
posterior meatal wall
• Loss of taste ( Electrogustometry)
• Schirmer test : Reduced lacrimation
• Motor fibres: Affected late
• Delayed blink reflex
12. Brainstem Involvement
• Ataxia
• Weakness & Numbness of arms
and legs
• Exaggerated tendon reflexes
Raised Intra-cranial tension
Headache, nausea, vomiting, diplopia(6th) &
papillo-edema with blurring of vision.
13. Cerebellar involvement
• Pressure symptoms on cerebellum are seen in
large tumors
• Revealed by
Finger-nose test
Knee-heel test
Dysdiadochokinesia
Ataxic gait
Inability to walk along a straight line (tendency to
fall on the affected side)
14. Investigations
• Audiological tests:
1. PTA
2. Speech Audiometry
3. Recruitment
phenomena: Absent
4. Short Increment
Sensitivity Index: 0-20%
5. Threshold tone decay
test : Retrocochlear type
of lesion
15. Vestibular Tests
• Caloric test:
Diminished or absent
response in 96% of
patients
May be normal when
tumour is small
17. Radiological tests
1. Plain X-ray:
• Positive in 80% of patients
• Different views:
1. Transorbital
2. Stenver’s
3. Towne’s
4. Submentovertical
2. Vertebral angiography:
• Helps in differentiating AN from other tumours
18. Radiological Test
3. CT scan:
• More sensitive than X-ray
• Can detect even intra-meatal and
posterior fossa tumors
4. MRI with Gadolinium contrast:
• GOLD Standard
• Can detect even intracanalicular
tumours of few mm
20. Other tests
• BERA:
A delay of >0.2ms in
wave V between 2 ears in
case of 8th nerve tumour
• CSF Examination:
Protie level raised, Lumbar
puncture should be
avoided
21. Investigations
Important tests for AN work-up:
• PTA
• Speech discrimination score
• Roll-over curve
• Stapedial reflex decay
• BERA
• MRI with gadolinium contrast
22. Differential Diagnosis
• Meniere’s Disease
• Tumours of CPangle:
1. Meningioma
2. Epidermoid
3. Arachnoid Cyst
4. Schwannoma of other cranial nerves
5. Aneurysm
6. Glomus tumour
7. Metastasis
26. X-knife/ɣ-knife surgery
• Stereotactic radiotherapy
• Advantages:
1. Minimal radiological effect
2. Causes reduction in tumour size &
growth.
3. Can be used in patients where surgery is
not feasible.
• Procedure : linear accelerator
ɣ-knife through cobalt-60
27. Radiotherapy
Conventional:
• Not prefered now due to low
tolerance of CNS to radiation
Cyber knife:
• Modified X-knife
• More accurate & frameless
• Method: real-time image
guidance technology through
computer controlled robotics.