The document discusses a study investigating the mechanism of calcification in hydrophilic intraocular lenses (IOLs). The study used scanning electron microscopy and energy dispersive x-ray analysis of explanted calcified IOLs. The results showed deposits of hydroxyapatite crystals both on and within the IOLs, forming near ruptures. An experimental model simulating the aqueous humor environment found hydroxyapatite deposits forming on IOL surfaces over time. The aqueous humor provides ions that supersaturate and allow hydroxyapatite crystals to form, facilitated by hydroxyl groups on the IOL material. Understanding calcification will help prevent this complication and avoid necessary IOL explantation and replacement.