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A. The Levinthal paradox revealed that it would be impossible for proteins to fold up into their
native structure in a biological meaningful timeframe if they were required to search all available
conformational space. Name two early events in protein folding that enable proteins to limit the
conformational space they need to sample to find their native conformation 10 morlel B. There is
a dramatic decrease in the entropy of a protein during the course of protein folding. Does this
process disobey the Second Law of Thermodynamics? Explain your answer. (2 marks)

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