Bill Gates discussed his annual letter which highlighted the success in helping the poorest people in the world survive diseases and feed their children through increased aid. However, some question how to prioritize aid given economic difficulties in their own countries. Gates argues aid is a small percentage of budgets but can save lives, so it should not be reduced. He also discussed ensuring aid effectiveness, balancing GMO opportunities and concerns country by country, population growth challenges, continued support for organizations like the Global Fund, and progress toward polio eradication.