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The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
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Lesson 3.7 (ten social) Senior Citizen
Universal brotherhood promotes treating all individuals equally regardless of attributes like race, religion, or economic status. It defines the world as a shared home and works to foster truth, tolerance, and peace. While humans tend to divide along various lines, developing a sense of universal brotherhood can help reduce issues like distrust and conflict by cultivating mutual love and respect among all people. The document discusses how universal brotherhood aims to unite people in shared humanity and make the world a better place for everyone through compassion and social responsibility.
Lesson 3.3 (ten social) Nepali Folk Musical Instruments
This document discusses traditional Nepali musical instruments. It begins by defining folk music and explaining that folk instruments are made using local materials and accompany folk songs. It then describes several traditional Nepali instruments like the madal, sarangi, flute, and instruments used in Panchai Baja performances. The document notes that many of these instruments are becoming extinct and suggests measures like including them in school curriculum, raising public awareness, and holding competitions to help preserve them. It lists causes of extinction as Western culture's impact, lack of training programs, and less opportunities to use the instruments. The homework questions ask about how instruments reflect culture and how to change young people's declining interest in folk music.
Lesson 3.1 (ten social) Our National Heritages
The document discusses Nepal's national heritages that have been recognized by UNESCO as World Heritage Sites. It notes that UNESCO has classified heritages into natural, cultural and digital types. For Nepal, four sites have been included as cultural heritages - the Kathmandu Valley, Lumbini, Changunarayan Temple, and Boudhanath Stupa. Two sites are natural heritages - Sagarmatha National Park and Chitwan National Park. The document provides details about each of these heritages, describing their historical and cultural significance. It emphasizes the importance of preserving these sites as they represent Nepal's culture, history and identity.
Lesson 3.8 (ten social) Elder Citizen and our Responsibility
The document discusses responsibilities towards senior citizens. It notes that aging is a natural process and defines senior citizens as those over 60 years old in most countries. As people age, they experience physical and mental changes. Society should provide support through day centers, allowances, employment opportunities, and clubs. Family members should provide emotional support, a safe home, and spend quality time with seniors. The government provides some social security programs and transportation privileges for seniors. It is important to care for their physical, mental, and emotional well-being as they age. Communities and the state should implement laws and programs to better support the elderly.
Lesson 3.7 (ten social) Universal Brotherhood
Universal brotherhood promotes treating all individuals equally regardless of attributes like race, religion, gender, or economic status. It defines the world as a shared home and works to foster tolerance, truth, and peace. While humans tend to divide along various lines, developing a sense of universal brotherhood can help reduce issues like distrust, hatred, and violence by cultivating mutual love, sympathy and respect between all people. Universal brotherhood aims to unite people in recognizing our shared humanity.
Lesson 3.6 (ten social) International Personalities and their Contributions
The document discusses two international personalities - Kailash Satyarthi and Dr. Martin Luther King Jr. It summarizes their contributions:
Kailash Satyarthi won the Nobel Peace Prize for rescuing over 80,000 child laborers in India and founding organizations dedicated to ending child labor.
Dr. Martin Luther King Jr. led the American civil rights movement and was a pioneer of nonviolent protest. He organized the March on Washington and delivered his iconic "I Have a Dream" speech calling for racial equality.
Both figures worked to improve human rights and welfare through nonviolent activism, and are recognized globally for their humanitarian efforts.
Lesson 3.5 (ten social) Our National Days
Nepal observes several national days each year to commemorate important historical events. Some of the most important national days discussed in the document are Martyr's Day on 16th Magh, Democracy Day on 7th Falgun, and Constitution Day on 3rd Aswin. These days honor those who fought for democracy and helped establish Nepal's constitution. It is the duty of citizens to observe national days and understand the significance of what happened on those days in Nepal's history.
Lesson 3.4 (ten social) Nepali Folk Dances and Classical Dances
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Lesson 3.7 (ten social) Senior Citizen
Universal brotherhood promotes treating all individuals equally regardless of attributes like race, religion, or economic status. It defines the world as a shared home and works to foster truth, tolerance, and peace. While humans tend to divide along various lines, developing a sense of universal brotherhood can help reduce issues like distrust and conflict by cultivating mutual love and respect among all people. The document discusses how universal brotherhood aims to unite people in shared humanity and make the world a better place for everyone through compassion and social responsibility.
Lesson 3.3 (ten social) Nepali Folk Musical Instruments
This document discusses traditional Nepali musical instruments. It begins by defining folk music and explaining that folk instruments are made using local materials and accompany folk songs. It then describes several traditional Nepali instruments like the madal, sarangi, flute, and instruments used in Panchai Baja performances. The document notes that many of these instruments are becoming extinct and suggests measures like including them in school curriculum, raising public awareness, and holding competitions to help preserve them. It lists causes of extinction as Western culture's impact, lack of training programs, and less opportunities to use the instruments. The homework questions ask about how instruments reflect culture and how to change young people's declining interest in folk music.
Lesson 3.1 (ten social) Our National Heritages
The document discusses Nepal's national heritages that have been recognized by UNESCO as World Heritage Sites. It notes that UNESCO has classified heritages into natural, cultural and digital types. For Nepal, four sites have been included as cultural heritages - the Kathmandu Valley, Lumbini, Changunarayan Temple, and Boudhanath Stupa. Two sites are natural heritages - Sagarmatha National Park and Chitwan National Park. The document provides details about each of these heritages, describing their historical and cultural significance. It emphasizes the importance of preserving these sites as they represent Nepal's culture, history and identity.
Lesson 3.8 (ten social) Elder Citizen and our Responsibility
The document discusses responsibilities towards senior citizens. It notes that aging is a natural process and defines senior citizens as those over 60 years old in most countries. As people age, they experience physical and mental changes. Society should provide support through day centers, allowances, employment opportunities, and clubs. Family members should provide emotional support, a safe home, and spend quality time with seniors. The government provides some social security programs and transportation privileges for seniors. It is important to care for their physical, mental, and emotional well-being as they age. Communities and the state should implement laws and programs to better support the elderly.
Lesson 3.7 (ten social) Universal Brotherhood
Universal brotherhood promotes treating all individuals equally regardless of attributes like race, religion, gender, or economic status. It defines the world as a shared home and works to foster tolerance, truth, and peace. While humans tend to divide along various lines, developing a sense of universal brotherhood can help reduce issues like distrust, hatred, and violence by cultivating mutual love, sympathy and respect between all people. Universal brotherhood aims to unite people in recognizing our shared humanity.
Lesson 3.6 (ten social) International Personalities and their Contributions
The document discusses two international personalities - Kailash Satyarthi and Dr. Martin Luther King Jr. It summarizes their contributions:
Kailash Satyarthi won the Nobel Peace Prize for rescuing over 80,000 child laborers in India and founding organizations dedicated to ending child labor.
Dr. Martin Luther King Jr. led the American civil rights movement and was a pioneer of nonviolent protest. He organized the March on Washington and delivered his iconic "I Have a Dream" speech calling for racial equality.
Both figures worked to improve human rights and welfare through nonviolent activism, and are recognized globally for their humanitarian efforts.
Lesson 3.5 (ten social) Our National Days
Nepal observes several national days each year to commemorate important historical events. Some of the most important national days discussed in the document are Martyr's Day on 16th Magh, Democracy Day on 7th Falgun, and Constitution Day on 3rd Aswin. These days honor those who fought for democracy and helped establish Nepal's constitution. It is the duty of citizens to observe national days and understand the significance of what happened on those days in Nepal's history.
Lesson 3.4 (ten social) Nepali Folk Dances and Classical Dances
Nepali Folk Dances and Classical Dances
Lesson 3.1 (ten social) Our National Heritages
The document discusses Nepal's national heritages that have been recognized by UNESCO as World Heritage Sites. It notes that UNESCO has classified heritages into natural, cultural and digital types. For Nepal, four sites have been included as cultural heritages - the Kathmandu Valley, Lumbini, Changunarayan Temple, and Boudhanath Stupa. Two sites are natural heritages - Sagarmatha National Park and Chitwan National Park. The document provides details about each of these heritages, describing their historical and cultural significance. It emphasizes the importance of preserving these sites as they represent Nepal's culture, history and identity.
सामाजिक कक्षा दश नेपाली किताब
This document contains an introduction and table of contents for a curriculum development textbook. The introduction provides background on curriculum development in Nepal and acknowledges contributions from various experts and stakeholders. It expresses the hope that the textbook will help students develop skills and competencies outlined in the curriculum in an interactive way. The table of contents lists 27 chapters across 7 sections covering topics such as human and national development, social values and issues, citizenship awareness, geography, history and map skills.
Word classes / Part of speech
There are 9 main word classes or parts of speech in English: noun, verb, adjective, adverb, pronoun, preposition, conjunction, determiner, and interjection. Each word class describes the grammatical function that a word performs in a sentence. For example, nouns identify people, places or things, verbs describe actions or states of being, and adjectives describe nouns. Some words can belong to more than one class depending on how they are used.
Moral 8-1-2
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive functioning. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
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The document discusses the importance of local development planning and public participation in Nepal. It makes three key points:
1. Development planning is important for organizing development activities and achieving goals efficiently. The current federal system in Nepal gives significant powers to local governments to identify local needs and make development plans.
2. Local communities and committees submit development proposals to local governments. The proposals identify needs, select projects, draft plans, and estimate costs and resources with public participation.
3. Rural municipalities and municipalities have authority over local development. They formulate their own plans and implement projects focused on issues like infrastructure, education, and health. Public involvement is important in all stages from planning to implementation and monitoring.
Lesson 2.4 (ten social) Contemporary Development Goals and Nepal
The document discusses contemporary development goals for Nepal, including the Millennium Development Goals (MDGs) and Sustainable Development Goals (SDGs). It notes that the MDGs had eight goals to be achieved by 2015 to address global development challenges. A new set of seventeen SDGs were created since the MDGs timeframe ended. Nepal must work to achieve all of the SDGs by their deadline. The document also mentions that Nepal had partial success in achieving most of the MDGs based on Nepal's MDG Progress Report.
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The document discusses the importance of skilled human resources for development. It makes three key points:
1. Skilled human resources are critical infrastructure for development because they can effectively mobilize other resources like natural resources, plan development projects, and produce goods and services.
2. A country's level of development depends greatly on how well it produces and utilizes skilled labor through technical education and vocational training programs. Developed nations have highly skilled workforces.
3. There is a strong relationship between skilled labor and employment/income opportunities. People with skills more easily find jobs that pay well and have benefits, which allows for better standards of living and contributes to overall national development. Countries must work to align skills training with
Lesson 2.1 (ten social) Sustainable Development
This document contains a lesson on sustainable development taught by Nar Bahadur Pun to a 10th grade social studies class. It defines sustainable development as development that meets current needs without compromising future generations' ability to meet their own needs. It discusses how sustainable development aims for economic growth, social development, and environmental conservation. It also outlines objectives, features, and importance of sustainable development, as well as factors to consider in development activities to ensure sustainability.
Lesson 2.2 (ten social) Development Projects running in Nepal
The document discusses development projects in Nepal, including the President Chure Conservation Programme and Pokhara International Airport. The President Chure Conservation Programme aims to protect biodiversity in the Chure region and was initiated in the fourth five-year plan. Pokhara International Airport began construction in 2073 to develop tourism in Pokhara and serve as an alternative to Tribhuwan International Airport in Kathmandu. Both projects receive government funding and aim to boost regional and national economic development.
Language function 1
This document provides examples of key language functions and sample questions and responses for each function. It covers functions such as apologizing, greeting, expressing likes/dislikes, preferences, opinions, plans, clarifying, and speaking in general. For each function, it lists example questions and sample responses using appropriate grammar, vocabulary, and language to demonstrate that function. The document serves as a guide for language examiners to test examinees' knowledge of suitable responses for different language functions.
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This document provides an introduction and structure of the Grade 11-12 curriculum of Nepal for 2077 BS. It discusses the national goals of education in Nepal and outlines the overall structure of the secondary level curriculum. The curriculum is developed based on the National Curriculum Framework of Nepal 2076 BS. It aims to develop competent and competitive citizens who can contribute to the development of an inclusive and just Nepali society. The curriculum structure and subject curricula are developed keeping in mind the learning outcomes, subject content, teaching-learning methods and assessment aspects as guided by the national framework.
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The curriculum structure has two levels - secondary and higher secondary. Grade 11-12 fall under the higher secondary level which aims to develop skills like independent learning, connecting theory and practice, and lifelong learning. The curriculum is designed to help students according to the national curriculum framework and feedback from stakeholders. It covers expected learning outcomes, subject content, teaching methods, and assessment for various subjects.
Curriculum 11 12 (group-1)
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कक्षा ८ स्वास्थ्य शिक्षा
The passage discusses the human circulatory system which transports blood, nutrients, oxygen, and wastes throughout the body. It is made up of the heart, blood vessels, and blood. The heart pumps blood through arteries and veins to all parts of the body and then back to the heart and lungs to be replenished with oxygen. The heart is a muscular organ located in the chest cavity that continuously pumps blood through two circuits - the pulmonary circulation and the systemic circulation. The blood vessels include arteries, which carry oxygenated blood away from the heart; veins, which carry deoxygenated blood back to the heart; and capillaries, which connect arteries and veins and allow exchange of water, oxygen, nutrients and wastes
कक्षा ८ नैतिक शिक्षा
1. The story introduces Chotu, a boy from a small village who struggles in his studies due to coming from a poor family with uneducated parents.
2. One day on his way to school, Chotu witnesses a chicken repeatedly trying to fly over a canal with food in its beak but failing and falling into the water.
3. This incident makes Chotu reflect on his own situation and whether he should give up on his studies like the chicken did not persist in its efforts.
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Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
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The document discusses Nepal's national heritages that have been recognized by UNESCO as World Heritage Sites. It notes that UNESCO has classified heritages into natural, cultural and digital types. For Nepal, four sites have been included as cultural heritages - the Kathmandu Valley, Lumbini, Changunarayan Temple, and Boudhanath Stupa. Two sites are natural heritages - Sagarmatha National Park and Chitwan National Park. The document provides details about each of these heritages, describing their historical and cultural significance. It emphasizes the importance of preserving these sites as they represent Nepal's culture, history and identity.
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This document contains an introduction and table of contents for a curriculum development textbook. The introduction provides background on curriculum development in Nepal and acknowledges contributions from various experts and stakeholders. It expresses the hope that the textbook will help students develop skills and competencies outlined in the curriculum in an interactive way. The table of contents lists 27 chapters across 7 sections covering topics such as human and national development, social values and issues, citizenship awareness, geography, history and map skills.
Word classes / Part of speech
There are 9 main word classes or parts of speech in English: noun, verb, adjective, adverb, pronoun, preposition, conjunction, determiner, and interjection. Each word class describes the grammatical function that a word performs in a sentence. For example, nouns identify people, places or things, verbs describe actions or states of being, and adjectives describe nouns. Some words can belong to more than one class depending on how they are used.
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The document discusses the importance of local development planning and public participation in Nepal. It makes three key points:
1. Development planning is important for organizing development activities and achieving goals efficiently. The current federal system in Nepal gives significant powers to local governments to identify local needs and make development plans.
2. Local communities and committees submit development proposals to local governments. The proposals identify needs, select projects, draft plans, and estimate costs and resources with public participation.
3. Rural municipalities and municipalities have authority over local development. They formulate their own plans and implement projects focused on issues like infrastructure, education, and health. Public involvement is important in all stages from planning to implementation and monitoring.
Lesson 2.4 (ten social) Contemporary Development Goals and Nepal
The document discusses contemporary development goals for Nepal, including the Millennium Development Goals (MDGs) and Sustainable Development Goals (SDGs). It notes that the MDGs had eight goals to be achieved by 2015 to address global development challenges. A new set of seventeen SDGs were created since the MDGs timeframe ended. Nepal must work to achieve all of the SDGs by their deadline. The document also mentions that Nepal had partial success in achieving most of the MDGs based on Nepal's MDG Progress Report.
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The document discusses the importance of skilled human resources for development. It makes three key points:
1. Skilled human resources are critical infrastructure for development because they can effectively mobilize other resources like natural resources, plan development projects, and produce goods and services.
2. A country's level of development depends greatly on how well it produces and utilizes skilled labor through technical education and vocational training programs. Developed nations have highly skilled workforces.
3. There is a strong relationship between skilled labor and employment/income opportunities. People with skills more easily find jobs that pay well and have benefits, which allows for better standards of living and contributes to overall national development. Countries must work to align skills training with
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This document contains a lesson on sustainable development taught by Nar Bahadur Pun to a 10th grade social studies class. It defines sustainable development as development that meets current needs without compromising future generations' ability to meet their own needs. It discusses how sustainable development aims for economic growth, social development, and environmental conservation. It also outlines objectives, features, and importance of sustainable development, as well as factors to consider in development activities to ensure sustainability.
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The document discusses development projects in Nepal, including the President Chure Conservation Programme and Pokhara International Airport. The President Chure Conservation Programme aims to protect biodiversity in the Chure region and was initiated in the fourth five-year plan. Pokhara International Airport began construction in 2073 to develop tourism in Pokhara and serve as an alternative to Tribhuwan International Airport in Kathmandu. Both projects receive government funding and aim to boost regional and national economic development.
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This document provides examples of key language functions and sample questions and responses for each function. It covers functions such as apologizing, greeting, expressing likes/dislikes, preferences, opinions, plans, clarifying, and speaking in general. For each function, it lists example questions and sample responses using appropriate grammar, vocabulary, and language to demonstrate that function. The document serves as a guide for language examiners to test examinees' knowledge of suitable responses for different language functions.
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This document outlines the curriculum framework for grades 11-12 in Nepal. It discusses the national goals of education which include developing individual potential, fostering patriotism and ethics, and preparing students to contribute to national development and global citizenship.
The curriculum structure has two levels - secondary and higher secondary. Grade 11-12 fall under the higher secondary level which aims to develop skills like independent learning, connecting theory and practice, and lifelong learning. The curriculum is designed to help students according to the national curriculum framework and feedback from stakeholders. It covers expected learning outcomes, subject content, teaching methods, and assessment for various subjects.
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This document provides an introduction and structure of the Grade 11-12 curriculum for the academic year 2076 BS in Nepal. It discusses the national goals of education in Nepal and outlines the overall structure of the curriculum for secondary level (Grades 11-12). The curriculum is competency-based and aims to develop skilled, competitive and responsible citizens who can contribute to national development. It emphasizes the development of critical thinking, scientific temper, and skills required for higher education and the job market.
कक्षा ८ स्वास्थ्य शिक्षा
The passage discusses the human circulatory system which transports blood, nutrients, oxygen, and wastes throughout the body. It is made up of the heart, blood vessels, and blood. The heart pumps blood through arteries and veins to all parts of the body and then back to the heart and lungs to be replenished with oxygen. The heart is a muscular organ located in the chest cavity that continuously pumps blood through two circuits - the pulmonary circulation and the systemic circulation. The blood vessels include arteries, which carry oxygenated blood away from the heart; veins, which carry deoxygenated blood back to the heart; and capillaries, which connect arteries and veins and allow exchange of water, oxygen, nutrients and wastes
कक्षा ८ नैतिक शिक्षा
1. The story introduces Chotu, a boy from a small village who struggles in his studies due to coming from a poor family with uneducated parents.
2. One day on his way to school, Chotu witnesses a chicken repeatedly trying to fly over a canal with food in its beak but failing and falling into the water.
3. This incident makes Chotu reflect on his own situation and whether he should give up on his studies like the chicken did not persist in its efforts.
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There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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