Notussil Medical Facts

1. Medical Department
Therapeutics and Clinical Risk Management 2011:7 83-92

2. Fact 1:
•Notussil®
(Cloperastine) is a
central antitussive
that acts directly
and selectively on
the Bulbar cough
center in medulla
oblongata.

3. Fact 2:
•Unlike Codeine,
Notussil®(Cloperastine) is
a non-narcotic, centrally
acting antitussive
therefore it doesn’t cause
either depression for
respiratory center or
dependence.

4. Fact 3:
• Notussil®(Cloperastine)
inhibits the inflammatory &
allergic mediators (like
histamine & serotonin) that
stimulate peripheral cough
receptors.

5. Fact 4
•Notussil®
exhibits
bronchorelaxant
action as it
relaxes
bronchial
musculature.

6. Fact 5:
•Notussil® doesn’t
interfere with the
protective mucociliary
mechanism so that, it
can be used safely in
case of chronic
bronchitis unlike other
cough sedatives.

7. Fact 6:
• Notussil® has rapid onset of
action as the initial response
occurs in 20-30 minutes after oral
administration (at therapeutic
dose range of 10-20 mg, three
times daily for adults).

8. Fact 7:
• Notussil® is as effective as Codeine
in treatment of cough of various
causes with additional
bronchorelaxant effect and without
its side effects like dependency.

9. Fact 8:
• Notussil® is Superior to
Butamirate in reducing cough
frequency and intensity not
only during the day-time but
also during the night-time.

10. Best Regards from the Medical Department