This presentation discusses global startup ecosystems based on rankings from The Startup Genome. It began as an academic project to identify and rank the top entrepreneurial economies worldwide. The rankings identify factors like total funding and diversified funding sources. The top 20 ecosystems have a global distribution, with 6 US cities in the top 10 and representation from North America, Europe, Asia, and Latin America. Lessons are that ecosystems differ but can improve through measurement and community involvement, while operating globally presents challenges around competition, limited local resources, and entering new markets.