The document provides an agenda for the 2nd CUTEheart Workshop on Health Technology Assessment in Cardiovascular Disease held in Portugal on April 23rd, 2016. The workshop included sessions on international perspectives on health technology assessment in cardiovascular care, the main results and lessons from the CUTEheart project, and a round table discussion on implementing health technology assessment in Portugal. Speakers represented universities and research institutions from Portugal, the UK, USA, and Australia. The workshop provided an opportunity for stakeholders in cardiovascular health to discuss approaches to health technology assessment.