This document summarizes research from the Buck Institute on using amyloid-binding compounds to treat chronic diseases associated with protein aggregation. Scientists found that the amyloid dye compound Thioflavin T (ThT) extended lifespan in the nematode C. elegans by up to 60% and reduced frailty. ThT and related compounds like curcumin decreased protein aggregation and improved outcomes in C. elegans models of neurodegenerative diseases. Further research in mice also showed positive effects. The Buck Institute is pursuing collaborations to develop these compounds as therapeutics for diseases caused or exacerbated by protein aggregation such as Alzheimer's and Parkinson's.