BRCA1 is a protein that helps repair double strand DNA breaks, while BRCA1-deficient cancer cells have found a way to reduce levels of the 53BP1 protein in order to alter the DNA repair mechanism for their own growth. Silibinin is a constituent of milk thistle that kills skin cells mutated by UVA radiation, protecting against UV-induced skin damage and cancer by aiding the DNA repair process.
in the presention there isn't all the information. all the information is in the link belowe.
https://docs.google.com/file/d/0B5v1Ie4RpLVHQ3RUNi1qWXVJWUU/edit?usp=sharing
in the presention there isn't all the information. all the information is in the link belowe.
https://docs.google.com/file/d/0B5v1Ie4RpLVHQ3RUNi1qWXVJWUU/edit?usp=sharing
New Modern Way to Approach Cancer - 5th International Biobran WorkshopSheldon Stein
New Modern Way to Approach Cancer - 5th International Biobran Workshop Krakow , Poland June 9-11, 2017. Professor Jurasunas discusses the problems of conventional oncology and offers insight into less toxic and more efficient methods of cancer treatment. He offers case histories and reviews protocols
using Biobran and other modern methods against cancer, focusing on Strategic Immunotherapy, Apoptosis and Angiogenesis. He shows how Biobran improves cancer survival rates and metastases prevention and disease recurrence.
Professor Serge Jurasunas' upcoming presentation: "A New Way to Approach Cancer". This presentation is for the Medicine Week Congress in Baden Baden Germany, October 30 thru November 3rd, 2019.
Current concepts in the pathogenesis of cancer /certified fixed orthodontic c...Indian dental academy
Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
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Ceritinib(CAS:1032900-25-6) has been shown to be effective at treating patients whose disease progressed during or shortly after treatment with crizotinib and who currently have very limited treatment options, as well as patients who have not been treated before. Regarding safety, the adverse effects with Ceritinib generally appeared manageable.
Professor Serge Jurasunas - New Modern Way to Approach Cancer - Biobran Works...Sheldon Stein
How to Treat Cancer with Immunotherapy Utilizing Biobran through the Microbiome. Professional Presentation for Medical Practitioners with Clinical Cases By Professor Serge Jurasunas.
Anti-tumor drugs PPT Dr. Shahid Rasool.pptshahidrasool65
The learning Objectives are
1. To understand tumor, its types, causes and cell cycle of normal cell.
2. To learn and comprehend the pharmacognostic features of various plant and marine derived drugs having anticancer activity.
3. To know the anti cancer mechanism of these natural drugs.
BREAST CANCER DRUG DISCOVERY & RESEARCH FROM VARIOUS WELL KNOWN ETHNOMEDICINAL PLANTS. ESTABLISHED PHYTOMOLECULES WITH CHEMOPREVENTIVE, ANTICANCER ACTIVITIES WITH MINIMAL TOXICITY.
New Modern Way to Approach Cancer - 5th International Biobran WorkshopSheldon Stein
New Modern Way to Approach Cancer - 5th International Biobran Workshop Krakow , Poland June 9-11, 2017. Professor Jurasunas discusses the problems of conventional oncology and offers insight into less toxic and more efficient methods of cancer treatment. He offers case histories and reviews protocols
using Biobran and other modern methods against cancer, focusing on Strategic Immunotherapy, Apoptosis and Angiogenesis. He shows how Biobran improves cancer survival rates and metastases prevention and disease recurrence.
Professor Serge Jurasunas' upcoming presentation: "A New Way to Approach Cancer". This presentation is for the Medicine Week Congress in Baden Baden Germany, October 30 thru November 3rd, 2019.
Current concepts in the pathogenesis of cancer /certified fixed orthodontic c...Indian dental academy
Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
https://www.aasraw.com/products/crizotinib-powder/
https://www.aasraw.com/ceritinib/
Ceritinib(CAS:1032900-25-6) has been shown to be effective at treating patients whose disease progressed during or shortly after treatment with crizotinib and who currently have very limited treatment options, as well as patients who have not been treated before. Regarding safety, the adverse effects with Ceritinib generally appeared manageable.
Professor Serge Jurasunas - New Modern Way to Approach Cancer - Biobran Works...Sheldon Stein
How to Treat Cancer with Immunotherapy Utilizing Biobran through the Microbiome. Professional Presentation for Medical Practitioners with Clinical Cases By Professor Serge Jurasunas.
Anti-tumor drugs PPT Dr. Shahid Rasool.pptshahidrasool65
The learning Objectives are
1. To understand tumor, its types, causes and cell cycle of normal cell.
2. To learn and comprehend the pharmacognostic features of various plant and marine derived drugs having anticancer activity.
3. To know the anti cancer mechanism of these natural drugs.
BREAST CANCER DRUG DISCOVERY & RESEARCH FROM VARIOUS WELL KNOWN ETHNOMEDICINAL PLANTS. ESTABLISHED PHYTOMOLECULES WITH CHEMOPREVENTIVE, ANTICANCER ACTIVITIES WITH MINIMAL TOXICITY.
1. BRCA1-DEFICIENT CANCER CELLS TAKE
ADVANTAGE OF DNA.
SILIBININ KILLS SKIN CELLS MUTATED BY
UVA RADIATION.
REPAIR MECHANISM.
Tatiana Gil Franco
Medicine Student
3° semestre
U.P.B
2.
3.
4. Introduction
The BRCA1 protein helps
to mend double-strand
DNA breaks by promoting
homologous
recombination.
Silibinin, kills skin cells
mutated by UVA radiation
and protects against
damage by UVB
radiation.
6. BRCA1-DEFICIENT CANCER CELLS TAKE
ADVANTAGE OF DNA REPAIR MECHANISM
BRCA1
It’s a human caretaker gene
that produces a protein
called breast cancer type 1
susceptibility
protein, responsible for
repairing DNA.
The BRCA1 protein helps to
mend double-strand DNA
breaks by promoting
homologous recombination.
7. BRCA1-DEFICIENT CANCER CELLS TAKE
ADVANTAGE OF DNA REPAIR MECHANISM
53BPA1 Cathepsin L
It’s a protein that helps It’s a protease that
orchestrate a different destroys 53BP1 by
DNA repair entering the nucleus.
mechanism, nonhomol
ogous end joining vitamin D is a
(NHEJ) cathepsin L inhibitor
Cells lacking BRCA1
compensate by cutting
back on 53BP1.
8. BRCA1-DEFICIENT CANCER CELLS TAKE
ADVANTAGE OF DNA REPAIR MECHANISM
When they cultured breast cancer cells that were missing
BRCA1, the cells stopped growing. After two weeks of
lethargy, however, BOGA cells (BRCA1-deficient cells that
overcome growth arrest), began to divide again.
These cells showed increased levels of cathepsin L and
reduced amounts of 53BP1.
Eliminating cathepsin L from BOGA cells or dosing them with
vitamin D, a cathepsin L inhibitor, prevented the decline in
53BP1 abundance.
9. PERSONAL OPINION
This article explains how cancer
cells by cathepsin, 53BP1 attack,
inhibiting DNA repair mechanism. I
think this is very important because
the authors are proposing a
treatment for breast cancer.
10. Silibinin kills skin
cells mutated by
UVA radiation and
protects against
cancer.
Photochemistry and
photobiology.
(Jan. 31, 2013 )
11. SILIBININ KILLS SKIN CELLS MUTATED BY UVA
RADIATION AND PROTECTS AGAINST CÁNCER
Silibinin, also known
as silybin, is the major
active constituent
of silymarin, a
standardized extract of
the milk thistle seeds
containing mixture
of flavonolignans. Silibinin has also
demonstrated in vitro
anti-cancer
effects, estrogen
dependent and
independent human
breast carcinoma cells.
12. SILIBININ KILLS SKIN CELLS MUTATED BY UVA
RADIATION AND PROTECTS AGAINST CÁNCER
The first study, published
in the
journal Photochemistry
and Photobiology worked
with human skin cells
subjected to UVA
radiation.
The Agarwal Lab treated
these UVA-affected cells
with silibinin. With
silibinin, the rate at which
these damaged cells died
increased dramatically.
13. SILIBININ KILLS SKIN CELLS MUTATED BY UVA
RADIATION AND PROTECTS AGAINST CÁNCER
The second study shows
that instead of
beneficially killing cells
damaged by UVA
radiation, treatment with
silibinin protects human
skill cells from damage
by UVB radiation.
The UVB radiation makes
up about 5 percent of the
sun's radiation reaching
Earth.
14. PERSONAL OPINION
I think that it’s a very important new
because this tell us about the great
damage that UV light causes us
and show us how with the help of
the silibinin and a DNA repair
mechanism can prevent this
damage.
15.
16. MEDICAL UTILITY
Knowing about the mechanisms of DNA repair is
very important in the field of medicine as these
mechanisms are closely linked to health problems
such as cancer.
17. MEDICAL UTILITY
In the first news tell us
about breast cancer and
the BRCA1 protein
function in this pathology.
18. MEDICAL UTILITY
The second new describe
us the operation of
silibinin killing cells
damaged by UV rays.
19. REFERENCES
News medical “Silibinin kills skin cells mutated by UVA radiation and protects
against cáncer”
Jan 31, 2013. Photochemistry and photobiology.
< http://www.news-medical.net/news/20130131/Silibinin-kills-skin-cells-mutated-by-
UVA-radiation-and-protects-against-cancer.aspx>
News medical “BRCA1-deficient cancer cells take advantage of DNA repair
mechanism”
Jan 22, 2013. The Journal of Cell Biology.
<http://www.news-medical.net/news/20130122/BRCA1-deficient-cancer-cells-take-
advantage-of-DNA-repair-mechanism.aspx>
MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB.
Fac. de Medicina, 2006. 208 p.