Cross-platform mobile app development allows creating apps that can run on multiple operating systems using a single codebase, making development more efficient. Some popular cross-platform frameworks include Xamarin, React Native, Flutter, and Ionic. The document describes a quiz app developed using Flutter, which has three screens: a welcome screen, question screen that displays one question at a time, and a score screen at the end. While cross-platform apps allow code reuse, challenges include limited support for platform-specific APIs since each operating system implements features differently.