New class of therapeutic agents called soluble guanylate cyclase (sGC) stimulators.
Impairment of NO synthesis and signaling through the NO-sGC–cGMP pathway is involved in the pathogenesis of pulmonary hypertension.
Dual mode of action,
Directly stimulating sGC independently of NO, and
Increasing the sensitivity of sGC to NO.
vasorelaxation , antiproliferative and antifibrotic effects
New class of therapeutic agents called soluble guanylate cyclase (sGC) stimulators.
Impairment of NO synthesis and signaling through the NO-sGC–cGMP pathway is involved in the pathogenesis of pulmonary hypertension.
Dual mode of action,
Directly stimulating sGC independently of NO, and
Increasing the sensitivity of sGC to NO.
vasorelaxation , antiproliferative and antifibrotic effects
Dra. Margaret Redfield. Congreso ACC 2013, Estados Unidos. RELAX: Inhibidor de la fosfodiesterasa-5 no mostró beneficio en la insuficiencia cardiaca con función ventricular preservada. Encuentre más presentaciones de este congreso en la página oficial de SOLACI: www.solaci.org/
Effect of Inspiratory Muscle Training on Muscle Strength and Quality of Life ...kacm20
Effect of Inspiratory Muscle Training on Muscle Strength and
Quality of Life in Patients With Chronic Airflow Limitation:
a Randomized Controlled Trial
Investigation of the changes on muscular endurance in response to aerobic and...Sports Journal
The rationale of the study is to investigate the changes on muscular endurance in response to aerobic and
anaerobic training among type 2 diabetic patients. To achieve the purpose of the study 45 male type 2
diabetic patients from Ongole, in the southern state of Andhra Pradesh, India, were selected as subjects.
The subjects were selected in the age group of 45 to 50 years and they were randomly assigned into three
equal groups of 15 each. Experimental group-I performed aerobic training, experimental group-II
performed anaerobic training and group III acted as control. The muscular endurance was selected as
dependent variable. The data collected from the three groups prior to and post experimentation on
selected dependent variable was statistically analyzed to find out the significant difference if any, by
applying the analysis of covariance (ANCOVA). Whenever the obtained ‘F’ ratio value was found to be
significant for adjusted post-test means, the Scheffe’s test was applied as post hoc test. In all the cases the
level of confidence was fixed at 0.05 level for significance. The result of the study produced 20.48%
percentage of improvement due to aerobic training and 15.32% of improvement due to anaerobic training
in muscular endurance of the diabetic patients
Exercise testing is a non invasive procedure that provides diagnostic and prognostic information and evaluates an individual’s capacity for dynamic exercises
Dra. Margaret Redfield. Congreso ACC 2013, Estados Unidos. RELAX: Inhibidor de la fosfodiesterasa-5 no mostró beneficio en la insuficiencia cardiaca con función ventricular preservada. Encuentre más presentaciones de este congreso en la página oficial de SOLACI: www.solaci.org/
Effect of Inspiratory Muscle Training on Muscle Strength and Quality of Life ...kacm20
Effect of Inspiratory Muscle Training on Muscle Strength and
Quality of Life in Patients With Chronic Airflow Limitation:
a Randomized Controlled Trial
Investigation of the changes on muscular endurance in response to aerobic and...Sports Journal
The rationale of the study is to investigate the changes on muscular endurance in response to aerobic and
anaerobic training among type 2 diabetic patients. To achieve the purpose of the study 45 male type 2
diabetic patients from Ongole, in the southern state of Andhra Pradesh, India, were selected as subjects.
The subjects were selected in the age group of 45 to 50 years and they were randomly assigned into three
equal groups of 15 each. Experimental group-I performed aerobic training, experimental group-II
performed anaerobic training and group III acted as control. The muscular endurance was selected as
dependent variable. The data collected from the three groups prior to and post experimentation on
selected dependent variable was statistically analyzed to find out the significant difference if any, by
applying the analysis of covariance (ANCOVA). Whenever the obtained ‘F’ ratio value was found to be
significant for adjusted post-test means, the Scheffe’s test was applied as post hoc test. In all the cases the
level of confidence was fixed at 0.05 level for significance. The result of the study produced 20.48%
percentage of improvement due to aerobic training and 15.32% of improvement due to anaerobic training
in muscular endurance of the diabetic patients
Exercise testing is a non invasive procedure that provides diagnostic and prognostic information and evaluates an individual’s capacity for dynamic exercises
Oxygen Therapy is not Beneficial in COPD Patients with Moderate HypoxaemiaGamal Agmy
A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation
The Long-Term Oxygen Treatment Trial Research Group*
N Engl J Med. 2016 October 27; 375(17): 1617–1627
Jour Resp Cardiov Phy Ther. 2016; 5(1): 12-20.
�
ORIGINAL ARTICLE
EFFECTS OF CPAP ON THE PHYSICAL EXERCISE TOLERANCE OF MODERATE TO
SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE
!
MICHEL SILVA REIS1,2, HUGO VALVERDE REIS1,2, DANIEL TEIXEIRA SOBRAL1,2, APARECIDA MARIA
CATAI3, AUDREY BORGHI-SILVA4
!
1Research Group in Cardiorespiratory Physical Therapy (GECARE), Department of Physical Therapy, Faculty of
Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
2Physical Education Undergraduation Program, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
3Laboratory of Cardiovascular Physical Therapy, Department of Physical Therapy, UFSCar, São Carlos, SP, Brazil
4Laboratory of Cardiopulmonary Physical Therapy, Department of Physical Therapy, Universidade Federal de São
Carlos (UFSCar), São Carlos, SP, Brazil
!
!
Received September 21, 2016; accepted April 18, 2017
Objective: The aim of this study was to evaluate the effect of continuous positive airway pressure
(CPAP) on the exercise tolerance of patients with moderate to severe chronic obstructive pulmonary
disease (COPD). Methods: ten men with COPD (69 ± 9 years), FEV1/FVC (58.90 ± 11.86%) and FEV1
(40.98 ± 10.97% of predict) were submitted to a symptom-limited incremental exercise test (IT) on
the cyclo ergometer. Later, on another visit, they were randomized to perform a constant load
exercise protocol until maximal tolerance with and without CPAP (5cmH2O) in the following
conditions: i) 50% of the peak workload; and ii) 75% of the peak workload. Heart rate (HR), arterial
pressure (AP) and peripheral oxygen saturation were obtained at rest and during the exercise
protocols. For statistical procedures, Shapiro-Wilk normality test and two-way ANOVA with Tukey
post hoc (p<0.05) were performed. Results: There was a signi`icant improvement in exercise time
tolerance during the 75% of the peak workload protocol with CPAP when compared with
spontaneous breath (SB) (438±75 vs. 344±73ms, respectively). Conclusion: CPAP with 5 cmH2O
seems to be useful to improve exercise tolerance in patients with COPD.
!
!
!
!
!
!
Corresponding Author
Michel Silva Reis ([email protected])
!
Journal of Respiratory and CardioVascular Physical Therapy
KEYWORDS:
Noninvasive
ventilation;
COPD;
exercise
tolerance;
CPAP
mailto:[email protected]
Jour Resp Cardiov Phy Ther. 2016; 5(1): 12-20.
INTRODUCTON
Patients with chronic obstructive pulmonary disease
(COPD) present a reduced physical exercise tolerance that
can be determined by ventilatory and/or peripheral
mechanism1,2. Progressive increase in the expiratory
air`low resistance, which limits the tidal volume gain
beyond the expiratory and inspiratory reserve volumes,
may be accentuated because these patients ventilate ...
Randomized controlled trial of 12-week yoga therapy as lifestyle intervention...Yogacharya AB Bhavanani
Randomized controlled trial of 12-week yoga therapy as lifestyle intervention in patients of essential hypertension and cardiac autonomic function tests
Randomized controlled trial of 12-week yoga therapy as lifestyle intervention...Yogacharya AB Bhavanani
Background: In the Indian subcontinent, 118 million people are with hypertension, and this figure is anticipated to double by 2025. Yoga has been widely claimed to play a role in the prevention and management of psychosomatic, stress-induced, and lifestyle disorders such as hypertension. Aims and Objective: To study the effect of 12 weeks of yoga therapy as a lifestyle intervention on cardiac autonomic functions in patients of essential hypertension. Materials and Methods: Subjects with hypertension from the Medicine Outpatient Department of the Jawaharlal Institute of Postgraduate Medical Education and Research were randomized into control and yoga groups. The control group was treated only with the allopathic medicines. The yoga group was given 12 weeks of yoga therapy module designed by JIPMER Institute Advanced Center for Yoga Therapy Education and Research along with the routine medical treatment. The participants’ blood pressure and cardiac autonomic function were recorded before and after the 12 weeks of the study period. Result: No significant change was observed in the body weight (BW), body mass index (BMI), abdominal circumference, and waist–hip ratio (WHR) in both the control and yoga groups at the end of the 12 week-study period. There was a significant decrease in the resting systolic pressure (SP), diastolic pressure (DP), rate pressure product (RPP), and mean arterial pressure (MAP) in the yoga group. In contrast, there was no significant change in the SP, DP, RPP, and MAP of the control group. High frequency (HF) power, total spectral power, and HF normalized units (nu) showed a significant increase in the yoga group. Low frequency (LF) power, HF power, and LF (nu) showed a significant (p o 0.05) decrease in the yoga group at the end of the 12-week yoga therapy. Conclusion: Twelve weeks of yoga therapy reduced both the SP and DP in the yoga group. Furthermore, yoga therapy increased the heart rate variability and vagal tone and decreased the sympathetic tone in the subjects with hypertension. At the same time, it increased both the parasympathetic and sympathetic reactivity
Effects of souvenaid on plasma micronutrient levels and fatty acid profiles i...Nutricia
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Outcome study of pulmonary telerehab - respirehab for post COVID patientsSubodh Gupta
Respirehab's case paper of telerehab of post COVID patients for improving breathing capacity, physical endurance and patient well being. The online pulmonary rehab delivered excellent gains on various parameters like SGRQ, MMRC and SPO2. This would be very helpful for COPD patients suffering from shortness of breath (Dyspnea).
International Journal of Pharmaceutical Science Invention (IJPSI)inventionjournals
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online
EFFECTIVENESS OF ADJUVANT YOGA THERAPY IN DIABETIC LUNG: A RANDOMIZED CONTROL...Yogacharya AB Bhavanani
EFFECTIVENESS OF ADJUVANT YOGA THERAPY IN DIABETIC LUNG: A RANDOMIZED CONTROL TRIAL
Balaji Rajasekaran1, Ananda Balayogi Bhavanani2, Meena Ramanathan3
1 Assistant Professor, Centre for Yogic sciences, Aarupadai Veedu Medical Colleges, Vinayaka Missions Research Foundation, Pondicherry
2 & 3 Director and Deputy Director, Centre for Yoga Therapy, Education and Research, Sri Balaji Vidyapeeth, Pondicherry.
E-mail of presenter: balaji.rajasekaran@avmc.edu.in
Abstract:
Context: Recent studies provide ample evidence of the benefits of yoga in various chronic disorders. Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia and Sandler coined the term “Diabetic Lung" for the abnormal pulmonary function detected in diabetic patients due underlying pulmonary dysfunction. Yoga therapy may help in achieving better pulmonary function along with enhanced glycaemic control and overall health benefits.
Aim: To study the effect of adjuvant yoga therapy in diabetic lung through spirometry.
Settings and Design: Randomized control trial done as interdisciplinary collaborative work between Yoga Therapy, Pulmonary Medicine and Endocrinology departments of MGMC & RI, Sri Balaji Vidyapeeth Puducherry.
Materials and Methods: 72 patients of diabetic lung as confirmed by spirometry (<70% of expected) were randomized and divided equally into control group who received only standard medical treatment and yoga group who received yoga training thrice weekly for 4 months along with that. Yoga therapy protocol included yogic counseling, preparatory practices, Asanas or static postures, Pranayama or breathing techniques and relaxation techniques. Hathenas of the Gitananda Yoga tradition were the main practices used. Spirometry was done at the end of the study period. Data was analyzed by Student’s paired and unpaired ’t’ test as it passed normality.
Results: There was a statistically significant (p < 0.05) reduction in weight, BMI along with a significant (p < 0.01) improvement in pulmonary function (FEV1, FVC) in yoga group as compared to control group where parameters worsened over study period.
Conclusion: It is concluded from the present RCT that yoga has a definite role as an adjuvant therapy as it enhances standard medical care and hence is even more significant in routine clinical management of diabetes, improving physical condition and pulmonary function.
Key words: diabetic lung, PFT, hathenas, yoga therapy
Roti Bank Hyderabad: A Beacon of Hope and NourishmentRoti Bank
One of the top cities of India, Hyderabad is the capital of Telangana and home to some of the biggest companies. But the other aspect of the city is a huge chunk of population that is even deprived of the food and shelter. There are many people in Hyderabad that are not having access to
Piccola Cucina is regarded as the best restaurant in Brooklyn and as the best Italian restaurant in NYC. We offer authentic Italian cuisine with a Sicilian touch that elevates the entire fine dining experience. We’re the first result when someone searches for where to eat in Brooklyn or the best restaurant near me.
Key Features of The Italian Restaurants.pdfmenafilo317
Filomena, a renowned Italian restaurant, is renowned for its authentic cuisine, warm environment, and exceptional service. Recognized for its homemade pasta, traditional dishes, and extensive wine selection, we provide a true taste of Italy. Its commitment to quality ingredients and classic recipes has made it a adored dining destination for Italian food enthusiasts.
Ang Chong Yi Navigating Singaporean Flavors: A Journey from Cultural Heritage...Ang Chong Yi
In the heart of Singapore, where tradition meets modernity, He embarks on a culinary adventure that transcends borders. His mission? Ang Chong Yi Exploring the Cultural Heritage and Identity in Singaporean Cuisine. To explore the rich tapestry of flavours that define Singaporean cuisine while embracing innovative plant-based approaches. Join us as we follow his footsteps through bustling markets, hidden hawker stalls, and vibrant street corners.
At Taste Of Middle East, we believe that food is not just about satisfying hunger, it's about experiencing different cultures and traditions. Our restaurant concept is based on selecting famous dishes from Iran, Turkey, Afghanistan, and other Arabic countries to give our customers an authentic taste of the Middle East
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Department of Physical Medicine and Rehabilitation, Hasan Sadikin General Hospital - Faculty of
Medicine, Padjadjaran University, Bandung, Indonesia
ORIGINAL ARTICLE
ABSTRACT
To compare two aerobic exercisetraining program, asthmagymnasticand static ergocycle
exercise, in improving VO2P
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2. for partially-controlled asthmatic patients.
Methods: This study analysed 36 of partially-controlled asthmatic adult patients (aged 21-50 years
old) which were divided into two groups, asthma gymnastic (A, n=18) and ergocycle exercise (B,
n=18) each for 3x/week for 6 weeks. Before and after treatment, VO2max was measured using
Astrand ergocycle method and QoL using SGRQ.
Results: 2max in both groups (A 3.78 ml/kg/minute vs B 7.13 ml/
(p=0.00) in both groups, with higher total score found in group B (A 271.11 vs B 384.86, p=0.00).
Conclusion:Static ergocycle exercise increased the level ofVO2 max and QoLin partially-controlled
asthmatic adult patients better than asthma gymnastic.
Keywords: Asthma gymnastic, static ergocycle exercise, partially-controlled asthma, quality of life,
VO2max
INTRODUCTION
disease is characterized with episodic
wheezing, cough and chest tightness due to
Received in March 2015 and accepted for publication in
April 2015.
Tina Susilawati.
Department of Physical Medicine and Rehabilitation
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Sadikin General Hospital
No. 38 Pasteur, Bandung 40161, West Java, Indonesia.
Phone: +62 8121029461
airway obstruction especially at night or early
in the morning. The mechanism is considered
reversible spontaneously or with medication.1
Asthma is one of the common airway disease
that affects at least 300 milion individuals in the
world and its prevalence increases in the last 20
years.2 If it is not well-treated and prevented,
higher prevalence is predicted to happen in the
future.3
Adult sufferers of asthma usually have
constant symptoms of impaired function in daily
activities and sleep disturbance due to shortness
of breath. These things keep the patient worried
about being sick and force them to limit their
physical activities in the impact of reducing
quality of life (QoL). This is proven by Listyanti
(2003) that showed lower maximum oxygen
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symptoms relieving and improved QoL are the
main goals in treating this disease.4,5,6,7
Asthma is treated with medication and
non-medication methods with pulmonary
rehabilitation. Medications are given to control
and reduce symptoms, yet this is proven
inadequate.1,8
Preventingtheeventofexacerbation,
increasing lung function and reducing the event of
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whole treatment.1
Thus, pulmonary rehabilitation
should be considered completed in every patient in
which even after optimal medication they still feel
exercise tolerance, limited activity or impaired
health state.7
Pulmonary rehabilitation consists of
many components, such as physical exercise
which is considered as the basic principle,
education, nutrition, psychological support
and behavioural change.8
A systemic review
in 2005 conducted by Ram et al. recommended
20-30 minutes of regular aerobic exercise (2-3
times per week for a minimal of 4 weeks) in
2
max) in
asthmatic patient.9
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points of view in moderate and severe persistent
asthma patient was reviewed in a study by
Mendes et al. that captured increased VO2
max,
improved asthma symptoms and QoL, reduced
anxiety and depression by giving education,
breathing exercise and aerobic exercise (twice
per week for 3 months) compared to giving only
education and breathing exercises.10
Aerobic exercise in asthmatic cases can
be done by walking or running with treadmill,
swimming, gymnastics, or static ergocycle.9,11
Indonesia asthmatic gymnastics routine
as standardized by Indonesian Asthmatic
Foundation (Yayasan Asma Indonesia ±
,
$
)
5. consists of aerobic exercise and breathing
exercise. Anwar et al. in 1998 obtained
decreased clinical symptoms event and usage
increase of VO2
max by giving asthma
gymnastics routine (mean of 2.67 times per
week for 18 weeks).12
Another recommended exercise as stated
in the American College of Sport Medicine
(ACSM) for asthma patient is static ergocycle
exercise. This exercise is considered relatively
easy to perform, safe and comfortable. Blood
pressure and heart rate monitoring are two
things to be evaluated as the safety parameters
while cycling. Dosage in this type of exercise
is customized individually.11
Alamsyah (2005)
adopted three times per week for 6 weeks of
static ergocycle exercise in moderate persistent
increase of VO2
max.13
While QoL in chronic lung diseases
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Questionnaire (SGRQ), the British Thoracic
Society(BTS)alsorecommendstheusage of this
tool in asthma patients since it is more sensitive
in detecting clinical changes. Furthermore,
validity of this tool in different languages has
been advised as high.14
Both pulmonary programs mentioned
above has been proven to increase VO2
max,
reduce clinical symptoms and increase QoL, yet
the comparison between static ergocyle exercise
and Indonesian standard asthma gymnastic
routine has never been conducted before. This
is due to the difference in exercise intensity,
for instance, asthma gymnastics is more on
recreational purpose because it is performed
in a group with the same dosage for all the
participants, whereas static ergocycle dosage
is individualized.11-13
Hence, the purpose of
this study is to compare the effect of asthma
gymnastics and static ergocyle exercise in
improving VO2
max and SGRW based of QoL in
adult asthma patients.
METHODS
This study employed experimental method
with controlled random design before and after
intervention conducted in the Physical Medicine
and Rehabilitation Department of Hasan Sadikin
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December 2012. Subjects were chosen from
partially controlled asthmatic patients who
visited Pulmonology outpatient clinic of Hasan
Sadikin Hospital and Cibadak Hospital. We
included subjects aged 21-50 years; sedentary
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informed consent. Subjects were excluded when
the following clinical manifestation present:
hearing impairment, other lung diseases, history
of cardiovascular disease, diabetes mellitus,
neuromuscular and musculoskeletal disorder
that evading the procedures, oxygen saturation
total more than three times inattendance then
the subject would be dropped out.
Each subjects underwent spirometry
tests (with and without bronchodilators) and
electrocardiography in the beginning of the
study, while QoL evaluation with SGRQ and
static ergocycle stress test with Astrand method
were done before and after intervention. Forty
subjects were divided into two groups, a group
with asthma gymnastics (group A) and another
with static ergocycle exercise (group B). Each
groups received 3 times per week for 6 weeks
of exercises.
Group A received standardized asthma
gymnastic exerises, a revised version of 2003
with an hour duration. This routine consisted
of core A and B with aerobic exercise type 1,
Clinic method of static ergocycle exercise
with 10 minutes in duration in the beginning
and increased 5 minutes every week until 35
minutes at week 6. The intensity given was 80%
of VO2
max, obtained from stress test and also
increased by 5% each week if subjects were
able to complete 3 sessions of exercise without
any symptoms of shortness of breath.
Data were analyzed using normality,
descriptive and hypothesis tests. When normal
distribution were found among data, hypothesis
would be tested in t-test for differences in two
independent mean data, otherwise a non parametric
test was conducted with either Mann Whitney or
Wilcoxon Match Pairs test. Each analysis were
clearance were gained from ethic committee of
Hasan Sadikin Hospital, Bandung.
RESULTS
Each groups have 20 subjects in the beginning
and 4 of them dropped out in the way (2 from
each group). Subjects characteristics were found
Variables
42.83 (6.61) 42.56 (9.28) 0.46*)
BW 55.22 (11.07) 56.83 (5.68) 0.26*)
BH 152.72 (7.12) 152.28 (6.17) 0.84**)
BMI 23.53 (3.31) 24.61 (3.07) 0.33**)
Note: *) Mann Whitney U test; **) t-test; BW: body weight (kg); BH: body height (cm); BMI: body mass index (kg/m2)
difference in VO2
max was found in both groups
(p 0.00, table 2) with increased VO2
max higher
in group B (table 3) after 6-week intervention.
Table 2. Changes of VO2
Mean SD
Before
After
25.19
28.97
25.67
29.53
0.00
Before
After
26.05
7.81
33.18
9.04
0.00
Note: *) Wilcoxon Matched Pairs test; VO2 max (ml/kg/min)
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increased of all components of SGRQ (p
0.00, table 4). Furthermore, after 6 weeks of
intervention higher improvement of SGRQ was
Variables
Mean SD Mean SD
284.67 48.94 0.00*) 240.07 54.97 0.00*)
218.47 39.55 152.04 62.12
Activity 1 323.48 77.82 0.00**) 296.39 127.77 0.00**)
%
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228.67 70.77 184.42 97.12
391.43 79.95 0.00*) 352.80 77.13 0.00*)
288.45 78.71 168.96 73.15
Total 1 999.43 157.01 0.00*) 890.28 239.73 0.00*)
Total 2 728.32 170.23 505.42 212.88
Note: *) t-test; **) Wilcoxon Matched Pairs test;
Symptoms 1: before-6-week-intervention score of symptoms component of SGRQ; Symptoms 2: after-6-week-intervention score of symptoms
component of SGRQ; Activity 1: before-6-week-intervention score of activity component of SGRQ; Activity 2: after-6-week-intervention
score of activity component of SGRQ; Impact 1: before-6-week-intervention score of impact component of SGRQ; Impact 2: after-6-week-
intervention score of impact component of SGRQ;Total 1: before-6-weekintervention score of total component of SGRQ; Total 2: after-6-week-
intervention score of total component of SGRQ
DISCUSSION
This present study showed increased mean of
VO2
max after 6-week intervention between
asthma gymnastics (group A) and static
increased from 25.19 ml/kg/min to 28.97 ml/kg/
min in group A showed a mean increase of 3.78
ml/kg/min that was similar to a study by Anwar
after a mean of 2.67 times of exercise per week
for 18 weeks. Anwar used asthma gymnastics
1994 version with 45 minutes of duration which
consists of core exercise A and B in addition
to aerobic exercise, while different version is
used in this study (revised 2003 version, 1 hour
duration).15
VO2
max also happened with mean of 26.05 ml/
kg/min became 33.18 ml/kg/min (increased by
7.13 ml/kg/min) after 6-week static ergocycle
exercise. It was higher in comparison to another
study by Ram et al. (2005) with resulted mean of
5.4 ml/kg/min. This is also found in accordance
with another study by Alamsyah (2005) which
gave three times per week static ergocycle for
6 weeks described mean increase of VO2
max
of 5.27 ml/kg/min in adult with persistent
asthma and also with Mendes et al. (2010) when
increased 10% VO2
max found after 30-minute
aerobic exercise twice a week for 3 months.8,10,13
These differences among studies are explained
of exercise, duration, intensity and exercise
frequency.
Asthma gymnastics routine is one of
physical activities included in aerobic exercise
especially targeting upper and lower extremity
muscles, whilst static ergocycle exercise aimed
particularly at the lower extremity muscles.
energy demands and increase work load of
cardiopulmonary system which shown in
increased heart rate and ejection volume. In
regular physical activities that contracts
big muscle groups are needed to obtain
cardiopulmonary responses.11,15,16
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Alamsyah (2005) studied static ergocycle
exercise to moderate persistent asthma patients
using Cooper Clinic method. This method
started with a 2.5-minute stage and each week
increased with 2.5 minutes. Intensity was
chosen 70 % heart rate.13 Mendes et al. (2010)
conducted aerobic exercise to moderate and
severe persistent asthma patients aged 20-50
years with 30 minutes duration, 2 sessions per
week for 3 months. The difference was the
chosen intensity, which was started with 60 %
of VO2
70 % VO2
max, moreover when subjects were
able to do two sessions without shortness of
breath symptoms the intensity is increased 5 %
more.10
Clinic method which conducted as follow:
increased duration by 5 minutes every week
until reaches 35 minutes in week 6. The starting
duration was chosen higher than any previous
studies and also with higher preferred intensity
(80%). These differences in contrast to other
studies reason for higher results of increased
mean of VO2
max.10,12,17
Pulmonary rehabilitation program which
uses high intensity endurance exercise will
ACSM recommends above 60% intensity of
aerobic exercise, yet higher recommendation by
Cassaburi et al. with 70-80% of maximum work
load in static ergocycle exercise.11,17
Increased
exercise capacity in group B showed physical
adaptation as increased oxidative capacity of
lower extremity muscle groups.18
This study
adopted 80% intensity and its 5% increase every
week in group B was shown well tolerated by
subjects even though with shorter duration
(6 weeks). The recommended duration of 30
minutes is done differently in this study with
short duration (10 minutes) in the beginning
until 35 minutes in the end in order to prevent
exercise-induced bronchoconstriction (EIB).11,13
Increased mean of VO2
max in static
ergocycle group of 7.13 ml/kg/min was
illustrated higher than group A (asthma
gymnastics, 3.78 ml/kg/min). Theoretically
better result of static ergocyle is as expected
of intensity as each subject received the exact
intensity from individualized stress test. Each
dosage in duration and intensity was then
increased each week with the same procedure
to do 50 rpm.10,17
Thus far, exercise dosage in asthma
gymnasticsgroupwasgeneralizedasofduration,
frequency, and standardized movements.16
Therefore, exercise intensity can not be
determined to conclude the dose. Consequently,
not all movements were done perfectly as
instructed since the subjects complained of
lower extremity fatigue when doing jumping
and running. This explains the unequal exercise
intensity of the standardized routine to each
aerobic capacity.
Events of shortness of breath during
physical activity or fear that overwhelms during
the activity in asthmatic patients will induce
the symptoms itself. This will further limit the
patient him/herself from any physical actions.10
asthmatic patients when matched to able-bodied
individuals.6
Each asthmatic patient admitted
being disturbed by asthma symptoms in daily
activities.14
Furthermore, limitation in social
life and retreat of psychological well-being
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anxiety and depression will accompany with the
decreasing degree of uncontrollable asthma.19
Mendes et al.
related QoL questionnaire to evaluate three
components, physical activity limitation,
frequency of symptoms and psychosocial
increased QoL after giving twice a week of
aerobic exercise for 3 months compared to
breathing exercise.10
This present study used
SGRQ in evaluating symptoms, activity,
and psychosocial impacts in chronic lung
disease such as asthma. Symptoms component
measured frequency and degree of severity of
upper airway disturbance. Activity is measured
on limitation of activity due to shortness of
breath and activities that causes shortness
of breath. Psychosocial impacts include
social function and psychologic impairment.
Altogether, in total component, health related
three components.14
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Both groups in this study have increased
with the increased QoL (decreased score of
SGRQ in all components). This is by means of
statistically higher mean QoL measurements in
group B (384.86) and statistically different than
Well planned and measurable pulmonary
rehabilitationprogramsarecapable ofincreasing
ability in doing daily activities and exercise
capacity; decreasing shortness of breath events,
anxiety and depression episodes to better
overall quality of life in asthmatic patients. The
higher aerobic capacity or cardiopulmonary
endurance gained is due to increased oxydative
enzymes action in muscles, density and size of
is. Patient then will fear less in doing activities.
Reduced episodes of shortness of breath were
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and psychosocial life. In addition, Mendes et al.
in causing asthma as the reason behind the
reduced symptoms of shortness of breath after
performing aerobic exercises.10
Small sample size and asthma medication
throughout the study period is admitted as the
result.
CONCLUSION
Pulmonary rehabilitation program of aerobic
exercises was proven by this study as it is able
to improve VO2
asthmatic patients with better improvements
after static ergocycle exercise compared to
asthma gymnastics routine exercise.
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