3- Cystic fibrosis is a hereditary disorder that is recessive affectin (1).docx
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3. Cystic fibrosis is a hereditary disorder that is recessive affecting the lungs and digestive tract. People with cystic fibrosis have a mutation in the CFTR gene (transmembrane conductance regulator) that causes the CFTF protein to malfunction. Determine the genotypes of the parents and offspring for the following family scenarios in a and b below. Use ' C ' to indicate a dominant allele and ' C ' for a recessive allele). a. One parent with the recessive condition and the other parent who does not have the disorder have 2 children. Both children have Cystic fibrosis. 8 marks b. Two parents who do not have Cystic fibrosis have 4 children where 1 child has Cystic fibrosis. 10 marks NOTE: You must draw a Punnet square to determine the possible genotypes of the children. When two alternative genotypes are possible for an individual, indicate both. .
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+ 11 Explain why genetic diseases are very rare in humans.pdf
+
11. Explain why genetic diseases are very rare in humans. 3.4.U6 Many genetic diseases in
humans are due to recessive alleles of autosomal genes, although some genetic diseases are due
to dominant or co-dominant alleles. AND 3.4.A3 Inheritance of cystic fibrosis and Huntington's
disease. 12. Cystic fibrosis (CF) is caused by a mutation in the CFTR gene. Secretions (e.g.
mucus, sweat and digestive juices) which are usually thin instead become thick. The secretions
block tubes, ducts and passageways. Lung problems in most CF sufferers leads to a early death.
a. Analyse the pedigree chart below and deduce whether CF is a recessive, dominant or
codominant condition. Quote your evidence in your answer. b. What is the probability of two
parents who are both carriers of (one copy of) the recessive allele producing children affected by
CF? Show your workings. c. Deduce the genotypes of the selected individuals.d. D and $ are
planning to have another child. Using the information in the pedigree chart in the last question to
calculate the % chance that the child will suffer from CF.13. Huntington's Disease (HD) is a brain
disorder that affects a person's ability to think, talk, and move. HD is caused by a mutation in a
gene on chromosome 4 . 14. Is this a dominant or recessive condition? 15. Is this disorder
autosomal or sex-linked 16. Produce a punnett grid to explain the inheritance pattern seen in the
offspring of a normal mother and a heterozygous affected father. Don't forget to use a key to
explain the genotypes and allele symbols used..
1- Calculate the frequency of the recessive and dominant allele in the.pdf
1. Calculate the frequency of the recessive and dominant allele in the population. (round
to nearest hundredth)
1. Calculate the frequency of the recessive and dominant allele in the population. (round
to nearest hundredth)
1. Calculate the frequency of the recessive and dominant allele in the population. (round to
nearest hundredth)
2. Calculate the percentage of heterozygous and homozygous dominant individuals in the
population.
please show all your work :)
thank you
Jse the following information: Every person has two copies of the cystic fibrosis transmembrane
conductance regulator (CFTR) gene. A person must inherit two mutated copies of the CFTR
gene (one copy from each parent) to have cystic fibrosis (CF). Cystic fibrosis is an example of a
recessive disease. That means a person must have a mutation in both copies of the CFTR gene to
have CF. People who inherit one copy of the CFTR gene that contains a mutation and one
normal copy are considered CF carriers. CF carriers do not have the disease but can pass their
copy of the defective gene on to their children. In people with CF, mutations in the CFTR gene
disrupt the normal production or functioning of the CFTR protein found in the cells of the lungs
and other parts of the body. This protein is responsible for regulating the flow of salt and fluids
in and out of the cells in different parts of the body. Mutations in the CFTR gene cause the CFTR
protein to malfunction or not be made at all, preventing normal movement of salt and fluids. This
leads to a buildup of thick mucus, which in turn leads to persistent lung infections, destruction of
the pancreas, and complications in other organs. Suppose you are a doctor researching CF in
North American populations. You determined in previous research studies that the typical allele
frequency of the mutant CF allele ( f ) among Caucasians is 0.025 , while the frequency of the
normal allele ( F ) is 0.975 . You sample a population of New York City residents, and you
determined that 4,810 individuals have a normal phenotype, while 190 individuals exhibit CF.
Answer the following questions..
A new potentially disease-causing Cystic Fibrosis mutation.a) .pdf
A new potentially disease-causing \"Cystic Fibrosis\" mutation.
a) Report the position of the mutation that the PCR reaction will detect. Describe which base is
the one commonly found (also called wild-type) in the unaffected population and what it is
changed to in people with Cystic Fibrosis.
b) Explain where in the gene sequence this mutation is located and what is the predicted effect of
having this mutation. Use the +1 position as a reference for counting bases.
c) What can families learn from a genetic test that detects potential Cystic Fibrosis-causing
mutations?
d) Why is it useful to be able to test for genetic disease predisposition?
e) What should parents know about Cystic Fibrosis?
Solution
b) Mutations at the 508th position (DF508) in the CFTR gene located on human chromosome 7
cause CF . The effects of having this mutation include affected liver, kidney, pancreas and
intestine. Lung infections occur as the airways are clogged with mucus resulting in breathing
problems. Mucus secreted in pancreas does not allow the release of the important digestive
enzymes needed by the body to breakdown food and absorb vital nutrients. Other symptoms
include clubbing of fingers and toes, affected growth, infection in sinus.
d) Testing for genetic disease like CF beforehand determines the presence or absence of certain
mutations in the gene that can cause CF. So, it is useful to be able to test for genetic disease
predisposition.
e) A child that has inherited 1 copy of mutated CF gene inherited from each parent suffers from
Cystic Fibrosis. When any one of the parents is a carrier or have a family history of CF, they
must be genetically tested. Parents should be aware about this and go though the test..
CYSTIC FIBROSIS KNOW IT NOW!
Cystic fibrosis (also known as CF or mucoviscidosis) is a recessive multi-system genetic disease characterized by abnormal transport of chloride and sodium across epithelium, leading to thick, viscous secretions in the lungs, pancreas, liver, intestine.[Yankas JR, et al. (2004). "Cystic fibrosis adult care consensus conference report". Chest 125: 1-39.]
Little changes make a big difference case study
A case study designed for a first year undergraduate genetics course. Interrmittent iClicker questions enable students to recall information from previous slides and apply it through progression of the case study.
This case study was prepared as part of a pedagogical project to examine the effects of active learning versus passive learning. Animations included were independently designed using novice techniques in 3D MAX; as such they may contain inaccuracies and/or a few continuity errors.
5- Use the following pedigree to determine the probability that IV-1 (.docx
5. Use the following pedigree to determine the probability that IV-1 (child yet to be born) will have albinism. = has cystic fibrosis = = consanguineous marriage (cousins) 6. Using the following pedigrees, mark the genotype of each member and determine the mode of inheritance: B) C) I II III IV 1 2 0. Achondroplasia is an autosomal dominant form of dwarfism. People with achondroplasia are heterozygotes because carrying two copies of the dominant, mutant allele is fatal during embryogenesis. Two people with achondroplasia decide to start a family. A) Fill out a Punnett square for this couple. A) What is the probability that their first child born will be of average stature? B) What is the probability that this couple has two daughters with achondroplasia and one son of average stature in that order? C) What is the probability that this couple has two children with achondroplasia and one of average stature in any order?
.
7- Which of the following mutation types is expected to produce the mi.docx
7. Which of the following mutation types is expected to produce the mildest form of disease? A. Transposon insertion. B. Missense mutation. C. Nonsense mutation. D. Frameshift mutation. E. Deletion. 8. In cystic fibrosis, deletion mutation in the CFTR gene results in pancreatic insufficiency while missense mutation causes no pancreatic sufficiency. This is an example of A. locus heterogeneity. B , allelic heterogeneity. C. delayed age of onset. D. genome imprinting. E. anticipation. 9. In schizophrenia, symptom is more severe and has an earlier age of onset in the more recent generations of schizophrenia families. This is an example of A. locus heterogeneity. B. anticipation. C. delayed age of onset. D. allele heterogeneity. E. genome imprinting. 10. In the following list, wild type amino acid sequence is followed by sequences produced by different types of mutations. Identify the type of mutation most likely to cause each altered amino acid sequence. Wild type: Phe-Asn-Pro-Thr-Arg Mutation 1: Phe-Asn-Pro Mutation 2: Phe-Asn-Ala-His-Thr Mutation 3: Phe-His-Pro-Thr-Arg A. Mutations 1 is nonsense; 2 is missense and 3 is frameshift. B. Mutations 1 is missense; 2 is nonsense and 3 is frameshift. C. Mutations 1 is missense; 2 is frameshift and 3 is missense. D. Mutations 1 is nonsense; 2 is frameshift and 3 is missense. E. Mutations 1 is frameshift; 2 is missense and 3 is nonsense. 11. A 30 -year-old woman had a sister who died from infantile Tay-Sachs disease, an autosomal recessive disorder that is fatal by age 5 years. What is the probability that this woman is a heterozygous carrier? A. 1/2 B. 1/3 C. 1/4 D. 2/3 E. 3/4 12. The pedigree below shows inheritance of hemophilia A , an X -linked recessive disorder. What is the probability that any children between III-1 and III-2 is affected? Assume that individuals married into the family are homozygous or hemizygous normal. A. 1/2 B. 1/3 C. 1/4 D. 2/3 E. 3/4 13. A female carrier of an X-linked recessive condition marries a phenotypically normal man. What is the probability that their first child will be unaffected? A. 1/2 B. 1/3 C. 1/4 D. 2/3 E. 3/4 14. Marfan syndrome is caused by mutations in fibrillin gene. So far, several hundred mutations have been found in the gene and most of them are missense. Mutation in the gene affects eye (myopia), skeleton (dolichostenomelia), and heart (dilatation of aorta). Which of the following correctly describe this phenomenon? A. Locus heterogeneity and variable expression. B. Anticipation and allelic heterogeneity. C. Age-dependent penetrance and pleiotropy. D. Allelic heterogeneity and pleiotropy. E. Pleiotropy and incomplete penetrance.
.
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+ 11 Explain why genetic diseases are very rare in humans.pdf
+
11. Explain why genetic diseases are very rare in humans. 3.4.U6 Many genetic diseases in
humans are due to recessive alleles of autosomal genes, although some genetic diseases are due
to dominant or co-dominant alleles. AND 3.4.A3 Inheritance of cystic fibrosis and Huntington's
disease. 12. Cystic fibrosis (CF) is caused by a mutation in the CFTR gene. Secretions (e.g.
mucus, sweat and digestive juices) which are usually thin instead become thick. The secretions
block tubes, ducts and passageways. Lung problems in most CF sufferers leads to a early death.
a. Analyse the pedigree chart below and deduce whether CF is a recessive, dominant or
codominant condition. Quote your evidence in your answer. b. What is the probability of two
parents who are both carriers of (one copy of) the recessive allele producing children affected by
CF? Show your workings. c. Deduce the genotypes of the selected individuals.d. D and $ are
planning to have another child. Using the information in the pedigree chart in the last question to
calculate the % chance that the child will suffer from CF.13. Huntington's Disease (HD) is a brain
disorder that affects a person's ability to think, talk, and move. HD is caused by a mutation in a
gene on chromosome 4 . 14. Is this a dominant or recessive condition? 15. Is this disorder
autosomal or sex-linked 16. Produce a punnett grid to explain the inheritance pattern seen in the
offspring of a normal mother and a heterozygous affected father. Don't forget to use a key to
explain the genotypes and allele symbols used..
1- Calculate the frequency of the recessive and dominant allele in the.pdf
1. Calculate the frequency of the recessive and dominant allele in the population. (round
to nearest hundredth)
1. Calculate the frequency of the recessive and dominant allele in the population. (round
to nearest hundredth)
1. Calculate the frequency of the recessive and dominant allele in the population. (round to
nearest hundredth)
2. Calculate the percentage of heterozygous and homozygous dominant individuals in the
population.
please show all your work :)
thank you
Jse the following information: Every person has two copies of the cystic fibrosis transmembrane
conductance regulator (CFTR) gene. A person must inherit two mutated copies of the CFTR
gene (one copy from each parent) to have cystic fibrosis (CF). Cystic fibrosis is an example of a
recessive disease. That means a person must have a mutation in both copies of the CFTR gene to
have CF. People who inherit one copy of the CFTR gene that contains a mutation and one
normal copy are considered CF carriers. CF carriers do not have the disease but can pass their
copy of the defective gene on to their children. In people with CF, mutations in the CFTR gene
disrupt the normal production or functioning of the CFTR protein found in the cells of the lungs
and other parts of the body. This protein is responsible for regulating the flow of salt and fluids
in and out of the cells in different parts of the body. Mutations in the CFTR gene cause the CFTR
protein to malfunction or not be made at all, preventing normal movement of salt and fluids. This
leads to a buildup of thick mucus, which in turn leads to persistent lung infections, destruction of
the pancreas, and complications in other organs. Suppose you are a doctor researching CF in
North American populations. You determined in previous research studies that the typical allele
frequency of the mutant CF allele ( f ) among Caucasians is 0.025 , while the frequency of the
normal allele ( F ) is 0.975 . You sample a population of New York City residents, and you
determined that 4,810 individuals have a normal phenotype, while 190 individuals exhibit CF.
Answer the following questions..
A new potentially disease-causing Cystic Fibrosis mutation.a) .pdf
A new potentially disease-causing \"Cystic Fibrosis\" mutation.
a) Report the position of the mutation that the PCR reaction will detect. Describe which base is
the one commonly found (also called wild-type) in the unaffected population and what it is
changed to in people with Cystic Fibrosis.
b) Explain where in the gene sequence this mutation is located and what is the predicted effect of
having this mutation. Use the +1 position as a reference for counting bases.
c) What can families learn from a genetic test that detects potential Cystic Fibrosis-causing
mutations?
d) Why is it useful to be able to test for genetic disease predisposition?
e) What should parents know about Cystic Fibrosis?
Solution
b) Mutations at the 508th position (DF508) in the CFTR gene located on human chromosome 7
cause CF . The effects of having this mutation include affected liver, kidney, pancreas and
intestine. Lung infections occur as the airways are clogged with mucus resulting in breathing
problems. Mucus secreted in pancreas does not allow the release of the important digestive
enzymes needed by the body to breakdown food and absorb vital nutrients. Other symptoms
include clubbing of fingers and toes, affected growth, infection in sinus.
d) Testing for genetic disease like CF beforehand determines the presence or absence of certain
mutations in the gene that can cause CF. So, it is useful to be able to test for genetic disease
predisposition.
e) A child that has inherited 1 copy of mutated CF gene inherited from each parent suffers from
Cystic Fibrosis. When any one of the parents is a carrier or have a family history of CF, they
must be genetically tested. Parents should be aware about this and go though the test..
CYSTIC FIBROSIS KNOW IT NOW!
Cystic fibrosis (also known as CF or mucoviscidosis) is a recessive multi-system genetic disease characterized by abnormal transport of chloride and sodium across epithelium, leading to thick, viscous secretions in the lungs, pancreas, liver, intestine.[Yankas JR, et al. (2004). "Cystic fibrosis adult care consensus conference report". Chest 125: 1-39.]
Little changes make a big difference case study
A case study designed for a first year undergraduate genetics course. Interrmittent iClicker questions enable students to recall information from previous slides and apply it through progression of the case study.
This case study was prepared as part of a pedagogical project to examine the effects of active learning versus passive learning. Animations included were independently designed using novice techniques in 3D MAX; as such they may contain inaccuracies and/or a few continuity errors.
5- Use the following pedigree to determine the probability that IV-1 (.docx
5. Use the following pedigree to determine the probability that IV-1 (child yet to be born) will have albinism. = has cystic fibrosis = = consanguineous marriage (cousins) 6. Using the following pedigrees, mark the genotype of each member and determine the mode of inheritance: B) C) I II III IV 1 2 0. Achondroplasia is an autosomal dominant form of dwarfism. People with achondroplasia are heterozygotes because carrying two copies of the dominant, mutant allele is fatal during embryogenesis. Two people with achondroplasia decide to start a family. A) Fill out a Punnett square for this couple. A) What is the probability that their first child born will be of average stature? B) What is the probability that this couple has two daughters with achondroplasia and one son of average stature in that order? C) What is the probability that this couple has two children with achondroplasia and one of average stature in any order?
.
7- Which of the following mutation types is expected to produce the mi.docx
7. Which of the following mutation types is expected to produce the mildest form of disease? A. Transposon insertion. B. Missense mutation. C. Nonsense mutation. D. Frameshift mutation. E. Deletion. 8. In cystic fibrosis, deletion mutation in the CFTR gene results in pancreatic insufficiency while missense mutation causes no pancreatic sufficiency. This is an example of A. locus heterogeneity. B , allelic heterogeneity. C. delayed age of onset. D. genome imprinting. E. anticipation. 9. In schizophrenia, symptom is more severe and has an earlier age of onset in the more recent generations of schizophrenia families. This is an example of A. locus heterogeneity. B. anticipation. C. delayed age of onset. D. allele heterogeneity. E. genome imprinting. 10. In the following list, wild type amino acid sequence is followed by sequences produced by different types of mutations. Identify the type of mutation most likely to cause each altered amino acid sequence. Wild type: Phe-Asn-Pro-Thr-Arg Mutation 1: Phe-Asn-Pro Mutation 2: Phe-Asn-Ala-His-Thr Mutation 3: Phe-His-Pro-Thr-Arg A. Mutations 1 is nonsense; 2 is missense and 3 is frameshift. B. Mutations 1 is missense; 2 is nonsense and 3 is frameshift. C. Mutations 1 is missense; 2 is frameshift and 3 is missense. D. Mutations 1 is nonsense; 2 is frameshift and 3 is missense. E. Mutations 1 is frameshift; 2 is missense and 3 is nonsense. 11. A 30 -year-old woman had a sister who died from infantile Tay-Sachs disease, an autosomal recessive disorder that is fatal by age 5 years. What is the probability that this woman is a heterozygous carrier? A. 1/2 B. 1/3 C. 1/4 D. 2/3 E. 3/4 12. The pedigree below shows inheritance of hemophilia A , an X -linked recessive disorder. What is the probability that any children between III-1 and III-2 is affected? Assume that individuals married into the family are homozygous or hemizygous normal. A. 1/2 B. 1/3 C. 1/4 D. 2/3 E. 3/4 13. A female carrier of an X-linked recessive condition marries a phenotypically normal man. What is the probability that their first child will be unaffected? A. 1/2 B. 1/3 C. 1/4 D. 2/3 E. 3/4 14. Marfan syndrome is caused by mutations in fibrillin gene. So far, several hundred mutations have been found in the gene and most of them are missense. Mutation in the gene affects eye (myopia), skeleton (dolichostenomelia), and heart (dilatation of aorta). Which of the following correctly describe this phenomenon? A. Locus heterogeneity and variable expression. B. Anticipation and allelic heterogeneity. C. Age-dependent penetrance and pleiotropy. D. Allelic heterogeneity and pleiotropy. E. Pleiotropy and incomplete penetrance.
.
Clearly explaination plsss!!! 1- Cystic fibrosis (CF) is an inherited.pdf
Clearly explaination plsss!!!
1. Cystic fibrosis (CF) is an inherited chronic disease that affects the lungs and digestive
system of about 30,000 children and adults in the United States. It is caused by a recessive
allele that encodes a defective chloride channel. Genetic screening has determined that two
parents are carriers (heterozygous for CF). What is the probability that they have a child with
CF?
2. When crossing true-breeding yellow seeded peas with true-breeding green seeded peas,
the F1 generation all have yellow seeds. What genotypic and phenotypic ratio would you
expect in the F2 generation?
3.You work in a fruit fly lab. Every once in a while you notice a fly that has a golden body
color. Early one morning, you have the great fortune of finding two such flies: one a male,
and the other (in another culture) a female. Delighted, you cross one with the other and 48
progeny result: 34 golden and 14 normal color.
a. Which trait do you think is dominant: golden or normal color?
b. What do you think are the genotypes of the parents and their progeny?
c. What phenotypic ratios would you have expected from your answers to a and b?
d. How could you test your answer to b by genetic crosses?.
Clearly explaination plsss!!! 1- Cystic fibrosis (CF) is an inherited.pdf
Clearly explaination plsss!!!
1. Cystic fibrosis (CF) is an inherited chronic disease that affects the lungs and digestive
system of about 30,000 children and adults in the United States. It is caused by a recessive
allele that encodes a defective chloride channel. Genetic screening has determined that two
parents are carriers (heterozygous for CF). What is the probability that they have a child with
CF?
2. When crossing true-breeding yellow seeded peas with true-breeding green seeded peas,
the F1 generation all have yellow seeds. What genotypic and phenotypic ratio would you
expect in the F2 generation?
3.You work in a fruit fly lab. Every once in a while you notice a fly that has a golden body
color. Early one morning, you have the great fortune of finding two such flies: one a male,
and the other (in another culture) a female. Delighted, you cross one with the other and 48
progeny result: 34 golden and 14 normal color.
a. Which trait do you think is dominant: golden or normal color?
b. What do you think are the genotypes of the parents and their progeny?
c. What phenotypic ratios would you have expected from your answers to a and b?
d. How could you test your answer to b by genetic crosses?.
Preimplantation genetic diagnosis
An overview of the technique Pre-Implantation Genetic Diagnosis along with a case study on its use in diagnosing cystic fibrosis.
Gregor Mendel used pea plants to study heredity in a series of exper.docx
Gregor Mendel used pea plants to study heredity in a series of experiments. Mendel worked by carefully observing and recording traits in successive generations of plants. Knowledge about DNA and chromosomes came later.
This lab will apply genetic laws to human inheritance using Punnett squares.
Recall that DNA is wound tightly into chromosomes. Cells with only one set of chromosomes, such as sex cells, are
haploid
. When two haploid cells fuse during fertilization, a diploid zygote with two full sets of chromosomes is formed. Most cells of a mature individual are diploid.
Homologous chromosomes
have the same genes, but they might have different versions (
alleles
) of those genes.
Diploid
cells have two alleles for each gene. These alleles might be identical (gene A) or different (gene B). Each gene’s
locus
is its location on a chromosome.
Human traits come through dominant or recessive inheritance. For example, the cystic fibrosis traits carried by a dominant allele are always expressed, even if the recessive gene is present (FF or Ff). The recessive is only expressed when two copies of the recessive allele are present (ff).
Mother: Healthy carrier
F
f
Father: Healthy carrier
F
FF
Healthy non-carrier
Ff
Healthy carrier
f
Ff
Healthy carrier
FF
Affected
Human gender is carried on the X and Y chromosomes. Females are XX and males are XY. Heredity traits such as color blindness, which is the inability to distinguish among some colors, are carried on the X chromosome (X
c
). The presence of one normal X
C
will allow normal vision.
In this next set of exercises, you will determine the genotypes of the parents by considering the inheritance patterns of traits in their children. The following is a table of the phenotypes of the family members:
Phenotype
Alleles
Parents
Mother
Not color blind
Freckles
Type B blood
X
c
X
C
Ff
I
B
i
Father
Color blind
No freckles
Type A blood
X
c
Y
Ff
I
A
i
Children
Abby
Color blind
Freckles
X
c
X
c
Ff or ff
Brady
Not color blind
No freckles
X
C
Y
ff
Carly
Not color blind
No freckles
X
c
X
C
ff
Dennis
Color blind
Freckles
X
c
Y
Ff or ff
Exercise 1: Color Blindness
Using the alleles XC (not color blind) and Xc (color blind), distribute the gametes from each parent to the outside of the Punnett square. Drag and drop the child with the correct phenotype to the box within the Punnett square that has the corresponding genotype that would occur from the fusion of egg and sperm as indicated by your placement of the gametes.
Exercise 2: Freckles
Freckles are groups of cells on the skin that produce the pigment melanin, often in response to exposure to ultraviolet (UV) light. The gene for freckles is inherited in a dominant/recessive pattern. A person carrying even a single copy of the dominant allele (F) will have freckles. A person who is homozygous recessive (ff) will have no freckles.
Using the alleles F (freckles) and f (no freckles), distribute the gametes from each parent to the outside of the Punne.
Respond to your colleagues and respectfully agree or disagree with.docx
Respond
to your colleagues and respectfully agree or disagree with your colleague’s assessment and explain your reasoning. In your explanation, include why their explanations make physiological sense or why they do not
At least 2 references in each peer responses!
Cystic Fibrosis is an autosomal recessive disease that affects chromosome 7 on the DNA helix. The parents of the child with cystic fibrosis are both carriers of the disorder and likely have no symptoms and have no idea they are carriers. The disease is caused by a mutation in cystic fibrosis transmembrane regulator (CFTR). The CFTR regulates the flow of salt and fluids in and out of the cell. The CFTR protein provides instructions for the channel than transports negatively charged particles called chloride ions in and out of the cell and across the tissues. The lack of this channel causes the build-up of thick and sticky mucus because chloride helps with the movement of water across the tissues that assist with thinning the mucus. (CF Genetics: The Basics, 2020)
The organs that are affected most frequently are the lungs, digestive organs, pancreas, and reproductive organs. The thick mucus causes frequent lung infections and the cyst in the lungs. The thick mucus blocks the ducts of the pancreas and prevents the transport of digestive enzymes leading to malnutrition. The production of insulin is also affected by the thick mucus and cystic fibrosis patients can develop diabetes-related to this. Males with cystic fibrosis are infertile due to mucus plugging the vas deferens. Female with cystic fibrosis frequently have difficulty during pregnancy (Cystic Fibrosis, 2020).
Cystic fibrosis is a recessive disease and both parents must be carries to produce a child who has cystic fibrosis. The chances of two carriers having a child with cystic fibrosis are 25% and the chances that the child will have a 50% chance they are a carrier of the mutation and a 25% chance that the child will not be a carrier or have the disease. The person with cystic fibrosis has a child with a cystic fibrosis carrier then they have a 50% chance the child will have cystic fibrosis and a 50% chance they will be a carrier (Cystic Fibrosis, n.d.).
Cystic fibrosis is common in the Caucasian population with a frequency rate of 1 in 2500-3500 births. African American have a frequency rate of 1-17000 and Asian population have a frequency rate of 1-3100 births (CF Genetics: The Basics, 2020)
.
Genetic Diseases
It mainly describes three diseases
Duchnne Muscular dystrophy
SCID
Sickle Cell Anemia
On the supply side- a city- state or nation's biocapacity represents t.docx
On October 31, 2024, Affleck Company's general ledger shows a cash account balance of $8 , 451 . The company's cash receipts for the month total $74 , 680 , of which $71 , 385 has been deposited in the bank. In addition, the company has written checks for $72 , 521 , of which $71 , 306 has been processed by the bank. The bank statement reveals an ending balance of $13 , 041 and includes the following items not yet recorded ty Affleck: bank service fees of $330 , note receivable collected by the bank of $6 , 800 , and interest earned on the note of $1 , 220 . After closer inspection, Affieck realizes that the bank incorrectly charged the company's account $1 , 020 for an automatic withdrawal that should have been charged to another customer's account. The bank agrees to the error. Required: 1. Prepare a bank reconciliation to calculate the correct ending balance of cash on October 31, 2024. 2. Record the necessary entries to adjust the balance for cash. Complete this question by entering your answers in the tabs below. Prepare a bank reconcliation to calculate the correct ending balance of cash on October 31, 2024. (Amounts to be deducted should be indicated with a minus sign.) Record the necessary entries to adjust the balance for cash. (If no entry is required for a transaction/event, select Required" in the first account field.) Journal entry worksheet Note: Enter debits before credits.
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On the Internet or using academic sources- research the design of mult.docx
On November 1, 2022, the account balances of Splish Brothers Inc. were as follows. During November, the following summary transactions were completed. Nov. 8 Paid $2 , 108 for salaries due employees, of which $868 is for October salaries. 10 Received $4 , 232 cash from customers on account. 12 Received $3 , 844 cash for services performed in November. 15 Purchased equipment on account $2 , 480 , 17 Purchased supplies on account $868 . During November, the following summary transactions were completed. Nov. 8 Paid $2 , 108 for salaries due employees, of which $868 is for October salaries. 10 Received $4 , 232 cash from customers on account. 12 Received $3 , 844 cash for services performed in November. 15 Purchased equipment on account $2 , 480 . 17 Purchased supplies on account $868 . 20 Paid creditors on account $3 , 348 . 22 Paid November rent $496 . 25 Paid salaries $2 , 108 . 27 Performed services on account and billed customers $2 , 356 for these services. 29 Received $744 from customers for future service. Prepare a trial balance at November 30. (Do not list those accounts that have zero ending balance.)
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Similar to 3- Cystic fibrosis is a hereditary disorder that is recessive affectin (1).docx
Clearly explaination plsss!!! 1- Cystic fibrosis (CF) is an inherited.pdf
Clearly explaination plsss!!!
1. Cystic fibrosis (CF) is an inherited chronic disease that affects the lungs and digestive
system of about 30,000 children and adults in the United States. It is caused by a recessive
allele that encodes a defective chloride channel. Genetic screening has determined that two
parents are carriers (heterozygous for CF). What is the probability that they have a child with
CF?
2. When crossing true-breeding yellow seeded peas with true-breeding green seeded peas,
the F1 generation all have yellow seeds. What genotypic and phenotypic ratio would you
expect in the F2 generation?
3.You work in a fruit fly lab. Every once in a while you notice a fly that has a golden body
color. Early one morning, you have the great fortune of finding two such flies: one a male,
and the other (in another culture) a female. Delighted, you cross one with the other and 48
progeny result: 34 golden and 14 normal color.
a. Which trait do you think is dominant: golden or normal color?
b. What do you think are the genotypes of the parents and their progeny?
c. What phenotypic ratios would you have expected from your answers to a and b?
d. How could you test your answer to b by genetic crosses?.
Clearly explaination plsss!!! 1- Cystic fibrosis (CF) is an inherited.pdf
Clearly explaination plsss!!!
1. Cystic fibrosis (CF) is an inherited chronic disease that affects the lungs and digestive
system of about 30,000 children and adults in the United States. It is caused by a recessive
allele that encodes a defective chloride channel. Genetic screening has determined that two
parents are carriers (heterozygous for CF). What is the probability that they have a child with
CF?
2. When crossing true-breeding yellow seeded peas with true-breeding green seeded peas,
the F1 generation all have yellow seeds. What genotypic and phenotypic ratio would you
expect in the F2 generation?
3.You work in a fruit fly lab. Every once in a while you notice a fly that has a golden body
color. Early one morning, you have the great fortune of finding two such flies: one a male,
and the other (in another culture) a female. Delighted, you cross one with the other and 48
progeny result: 34 golden and 14 normal color.
a. Which trait do you think is dominant: golden or normal color?
b. What do you think are the genotypes of the parents and their progeny?
c. What phenotypic ratios would you have expected from your answers to a and b?
d. How could you test your answer to b by genetic crosses?.
Preimplantation genetic diagnosis
An overview of the technique Pre-Implantation Genetic Diagnosis along with a case study on its use in diagnosing cystic fibrosis.
Gregor Mendel used pea plants to study heredity in a series of exper.docx
Gregor Mendel used pea plants to study heredity in a series of experiments. Mendel worked by carefully observing and recording traits in successive generations of plants. Knowledge about DNA and chromosomes came later.
This lab will apply genetic laws to human inheritance using Punnett squares.
Recall that DNA is wound tightly into chromosomes. Cells with only one set of chromosomes, such as sex cells, are
haploid
. When two haploid cells fuse during fertilization, a diploid zygote with two full sets of chromosomes is formed. Most cells of a mature individual are diploid.
Homologous chromosomes
have the same genes, but they might have different versions (
alleles
) of those genes.
Diploid
cells have two alleles for each gene. These alleles might be identical (gene A) or different (gene B). Each gene’s
locus
is its location on a chromosome.
Human traits come through dominant or recessive inheritance. For example, the cystic fibrosis traits carried by a dominant allele are always expressed, even if the recessive gene is present (FF or Ff). The recessive is only expressed when two copies of the recessive allele are present (ff).
Mother: Healthy carrier
F
f
Father: Healthy carrier
F
FF
Healthy non-carrier
Ff
Healthy carrier
f
Ff
Healthy carrier
FF
Affected
Human gender is carried on the X and Y chromosomes. Females are XX and males are XY. Heredity traits such as color blindness, which is the inability to distinguish among some colors, are carried on the X chromosome (X
c
). The presence of one normal X
C
will allow normal vision.
In this next set of exercises, you will determine the genotypes of the parents by considering the inheritance patterns of traits in their children. The following is a table of the phenotypes of the family members:
Phenotype
Alleles
Parents
Mother
Not color blind
Freckles
Type B blood
X
c
X
C
Ff
I
B
i
Father
Color blind
No freckles
Type A blood
X
c
Y
Ff
I
A
i
Children
Abby
Color blind
Freckles
X
c
X
c
Ff or ff
Brady
Not color blind
No freckles
X
C
Y
ff
Carly
Not color blind
No freckles
X
c
X
C
ff
Dennis
Color blind
Freckles
X
c
Y
Ff or ff
Exercise 1: Color Blindness
Using the alleles XC (not color blind) and Xc (color blind), distribute the gametes from each parent to the outside of the Punnett square. Drag and drop the child with the correct phenotype to the box within the Punnett square that has the corresponding genotype that would occur from the fusion of egg and sperm as indicated by your placement of the gametes.
Exercise 2: Freckles
Freckles are groups of cells on the skin that produce the pigment melanin, often in response to exposure to ultraviolet (UV) light. The gene for freckles is inherited in a dominant/recessive pattern. A person carrying even a single copy of the dominant allele (F) will have freckles. A person who is homozygous recessive (ff) will have no freckles.
Using the alleles F (freckles) and f (no freckles), distribute the gametes from each parent to the outside of the Punne.
Respond to your colleagues and respectfully agree or disagree with.docx
Respond
to your colleagues and respectfully agree or disagree with your colleague’s assessment and explain your reasoning. In your explanation, include why their explanations make physiological sense or why they do not
At least 2 references in each peer responses!
Cystic Fibrosis is an autosomal recessive disease that affects chromosome 7 on the DNA helix. The parents of the child with cystic fibrosis are both carriers of the disorder and likely have no symptoms and have no idea they are carriers. The disease is caused by a mutation in cystic fibrosis transmembrane regulator (CFTR). The CFTR regulates the flow of salt and fluids in and out of the cell. The CFTR protein provides instructions for the channel than transports negatively charged particles called chloride ions in and out of the cell and across the tissues. The lack of this channel causes the build-up of thick and sticky mucus because chloride helps with the movement of water across the tissues that assist with thinning the mucus. (CF Genetics: The Basics, 2020)
The organs that are affected most frequently are the lungs, digestive organs, pancreas, and reproductive organs. The thick mucus causes frequent lung infections and the cyst in the lungs. The thick mucus blocks the ducts of the pancreas and prevents the transport of digestive enzymes leading to malnutrition. The production of insulin is also affected by the thick mucus and cystic fibrosis patients can develop diabetes-related to this. Males with cystic fibrosis are infertile due to mucus plugging the vas deferens. Female with cystic fibrosis frequently have difficulty during pregnancy (Cystic Fibrosis, 2020).
Cystic fibrosis is a recessive disease and both parents must be carries to produce a child who has cystic fibrosis. The chances of two carriers having a child with cystic fibrosis are 25% and the chances that the child will have a 50% chance they are a carrier of the mutation and a 25% chance that the child will not be a carrier or have the disease. The person with cystic fibrosis has a child with a cystic fibrosis carrier then they have a 50% chance the child will have cystic fibrosis and a 50% chance they will be a carrier (Cystic Fibrosis, n.d.).
Cystic fibrosis is common in the Caucasian population with a frequency rate of 1 in 2500-3500 births. African American have a frequency rate of 1-17000 and Asian population have a frequency rate of 1-3100 births (CF Genetics: The Basics, 2020)
.
Genetic Diseases
It mainly describes three diseases
Duchnne Muscular dystrophy
SCID
Sickle Cell Anemia
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Clearly explaination plsss!!! 1- Cystic fibrosis (CF) is an inherited.pdf
Clearly explaination plsss!!! 1- Cystic fibrosis (CF) is an inherited.pdf
Clearly explaination plsss!!! 1- Cystic fibrosis (CF) is an inherited.pdf
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Wednesday 22 May 2024, 14:00-15:00.
Mule 4.6 & Java 17 Upgrade | MuleSoft Mysore Meetup #46
Mule 4.6 & Java 17 Upgrade | MuleSoft Mysore Meetup #46
Event Link:-
https://meetups.mulesoft.com/events/details/mulesoft-mysore-presents-exploring-gemini-ai-and-integration-with-mulesoft/
Agenda
● Java 17 Upgrade Overview
● Why and by when do customers need to upgrade to Java 17?
● Is there any immediate impact to upgrading to Mule Runtime 4.6 and beyond?
● Which MuleSoft products are in scope?
For Upcoming Meetups Join Mysore Meetup Group - https://meetups.mulesoft.com/mysore/
YouTube:- youtube.com/@mulesoftmysore
Mysore WhatsApp group:- https://chat.whatsapp.com/EhqtHtCC75vCAX7gaO842N
Speaker:-
Shubham Chaurasia - https://www.linkedin.com/in/shubhamchaurasia1/
Priya Shaw - https://www.linkedin.com/in/priya-shaw
Organizers:-
Shubham Chaurasia - https://www.linkedin.com/in/shubhamchaurasia1/
Giridhar Meka - https://www.linkedin.com/in/giridharmeka
Priya Shaw - https://www.linkedin.com/in/priya-shaw
Shyam Raj Prasad-
https://www.linkedin.com/in/shyam-raj-prasad/
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