It is a perennial or biennial herb of about 1-2 meters The seed of digitalis are small in size is 100,so they are mixed with sand for sowing. Favorable temperature range 20-30 c and rainfall 30-40 cm per annum and an altitude of 1600-3000m. The seedling is than transplanted into the field. Generally the leaves are collected in the afternoon during August and September with a belief that maximum cardio active glycosides are present at that time. The leaves are immediately dried after collection below 60℃ and dried leaves are stored in airtight containers. The dried leaves should not contain more than 5% moisture, since it promotes hydrolysis of cardiac glycosides resulting in loss of cardiac activity It is a perennial or biennial herb of about 1-2 meters The seed of digitalis are small in size is 100,so they are mixed with sand for sowing. Favorable temperature range 20-30 c and rainfall 30-40 cm per annum and an altitude of 1600-3000m. The seedling is than transplanted into the field. Generally the leaves are collected in the afternoon during August and September with a belief that maximum cardio active glycosides are present at that time. The leaves are immediately dried after collection below 60℃ and dried leaves are stored in airtight containers. The dried leaves should not contain more than 5% moisture, since it promotes hydrolysis of cardiac glycosides resulting in loss of cardiac activity It is a perennial or biennial herb of about 1-2 meters The seed of digitalis are small in size is 100,so they are mixed with sand for sowing. Favorable temperature range 20-30 c and rainfall 30-40 cm per annum and an altitude of 1600-3000m. The seedling is than transplanted into the field. Generally the leaves are collected in the afternoon during August and September with a belief that maximum cardio active glycosides are present at that time. The leaves are immediately dried after collection below 60℃ and dried leaves are stored in airtight containers. The dried leaves should not contain more than 5% moisture, since it promotes hydrolysis of cardiac glycosides resulting in loss of cardiac activityIt is a perennial or biennial herb of about 1-2 meters The seed of digitalis are small in size is 100,so they are mixed with sand for sowing. Favorable temperature range 20-30 c and rainfall 30-40 cm per annum and an altitude of 1600-3000m. The seedling is than transplanted into the field. Generally the leaves are collected in the afternoon during August and September with a belief that maximum cardio active glycosides are present at that time. The leaves are immediately dried after collection below 60℃ and dried leaves are stored in airtight containers. The dried leaves should not contain more than 5% moisture, since it promotes hydrolysis of cardiac glycosides resulting in loss of cardiac activityIt is a perennial or biennial herb of about 1-2 meters The seed of digitalis are small in size is 100,so they are mixed with sand for sowing. Favorable temperatur

1. PRESENTED BY – BITAN GHOSH
UNIVERSITY ROLL NO. – 20801920091
SUBJECT CODE – PT512
SEMESTER – 5th
SEMESTER
YEAR – 3rd
YEAR

2. CONTENTS
 INTRODUCTION
 BIOLOGICAL AND GEOGRAPHICAL SOURCE OF DIGITALIS
 CULTIVATION AND COLLECTION
 MORPHOLOGICAL CHARACTERS
 MICROSCOPIC CHARACTERS
 CHEMICAL CONSTITUENTS
 CHEMICAL TESTS
 USES
 ADULTERENTS
 REFERNENCES
DIGITALIS

3. Digitalis is a drug belonging to a group of drugs
called cardiac glycoside .
The drug has ability to exert a specific and powerful
action on the cardiac muscle in animals.
It has been used in the treatment of heart conditions
ever since it’s discovery in1775.
SYNONYMS
Digitalis leave, Foxglove leave.
INTRODUCTION

4.  BIOLOGICAL SOURCE
Digitalis obtained from the dried leaves of
Digitalis purpurea.
FAMILY – Scorphuleriaceae
 GEOGRAPHICAL SOURCE
It is cultivated and collected in England, other
parts of Europe, United States and India.
BIOLOGICAL AND GEOGRAPHICAL
SOURCE OF DIGITALIS

5.  It is a perennial or biennial herb of about 1-2 meters
 The seed of digitalis are small in size is 100,so they are mixed
with sand for sowing.
 Favorable temperature range 20-30 c and rainfall 30-40 cm per
annum and an altitude of 1600-3000m.
 The seedling is than transplanted into the field.
 Generally the leaves are collected in the afternoon during
August and September with a belief that maximum cardio active
glycosides are present at that time.
 The leaves are immediately dried after collection below 60℃
and dried leaves are stored in airtight containers.
 The dried leaves should not contain more than 5% moisture,
since it promotes hydrolysis of cardiac glycosides resulting in
loss of cardiac activity
CULTIVATION AND COLLECTION

6. The herb and leaf of Digitalis purpurea

7.  Colour - Dark greyish green
 Odour – Slight
 Taste – Bitter
 Size - 10 to 40 cm long and 4 to 20 cm wide
 Shape - Ovate-lanceolate to broadly ovate; with
irregularly crenate or serrate or dentate margin.
occasionally
MORPHOLOGICAL
CHARACTERS

8.  It is dorsivental leaf.
 It has anomocytic stomata covering and glandular trichomes on
both sides
 Glandular trichomes are short,
unicellular stalk and unicellular
or bicellular head.
 Covering trichomes are uniseriate
with colapsed cells
 Digitalis is free from Ca oxalate
crystals and sclerenchyma.
 Starch grains are present and
collenchyma is present
MICROSCOPIC CHARACTERS

9.  Digitalis contain 0.2 to 0.45% of both primary
and secondary glycosides.
 Primary glycosides are Purpurea glycosides A
and B, glucogetaloxin and Secondary
glycosides are digitoxin, gitoxin and getaloxin.
 Purpurea glycosides A and B constitute the
principle active constituent of the fresh leaves.
CHEMICAL CONSTITUENTS

10. Purpurea glycoside A Purpurea glycoside B
Ezymetic Enzymetic
Hydrolysis Hydrolysis
Digitoxin+Glucose Gitoxin+Glucose
Hydrolysis Hydrolysis
Digitoxigenin+ 3 Digitoxose Gitoxigenin+3 Digitoxose

11. CHEMICAL TESTS
 LEGAL TEST – Digitalis extract dissolved in pyridine
+ sodium nitroprusside
The pink and red colour is produced
 BALGET TEST – Section of Digitalis leaf + sodium picrate sol.
Yellow to orange colour produced
 KILLER KILLANI TEST –

12.  It is used in the treatment of congestive heart failure
 It increase excitability of cardiac muscle and produce
more powerful contractions.
 The major disadvantage of digitalis is that it has
cumulative effect so administration of drug should
be under strict medical supervision.
DOSAGE - 1-2 gm in 24-48 hours.
USES

13.  Primula vulgaris - (belonging to the Family-
Primulaceae) leaves are added to digitalis leaves.
 Symphytum officinale - (belonging to the Family-
Boraginaceae) leaves are added for adulteration
purposes.
 Verbascum thapsus - (belonging to the Family-
Scrophulariaceae) leaves are mixed with the genuine
drug of digitalis.
 ALLIED DRUGS - Digitalis lanta
ADULTARENTS

14.  Kokate. C. K, Purohit.A.P, Gokhale.S.B, Text book
of Pharmacognosy, 57th Edition, May, 2021,
Nirali Prakashani, page no:-9.31-9.35.
 Kabra.A, Ashok.P.K, Setia.S, Text book of
Pharmacognosy &Phytochemstry-11,2nd
Edition,2022, Pee Vee, page no:-7.44-7.47
REFERENCES

15. THANK YOU