The document summarizes the key discussions and presentations from the 2016 Sixteenth Population Health Colloquium. The Colloquium focused on challenges in implementing population health strategies and achieving the goals of the Affordable Care Act. Key topics included understanding patient fear, creating a new population health protection agenda to reduce costs, using data and technology to improve care for older adults, and engaging consumers in wellness programs. Presenters emphasized the need for collaborative, integrated care and addressing social determinants of health to improve population health outcomes and control rising healthcare costs.