Subject-matter experts from different disciplines gathered to provide relevant insights into stem cell and developmental biology, organ system function, and innovative approaches to regenerate or bioengineer a kidney.

1. OPENING PRESENTATION
Kidney Regeneration & Bioengineering
State-of-the-Science Summit

2. 6:15 p.m.
Structural Basis of Essential Kidney Functions
Dennis Brown, Harvard University
6:30 p.m.
Experience with Renal Assist Devices
Christopher J. Pino, University of Michigan
6:45 p.m.
Current State of Transplantation
John P. Vella, Maine Medical Center
7:00 p.m.
Q&A + Group Discussion
Led by SOS Chief Science Coordinators
Realistic Expectations:
What Clinicians Need
Right Now
Module 1
Tonight’s clinical perspective is
designed to lay the foundation for
tomorrow’s discussion.

3. Thomas Carroll, PhD
Department of Nephrology,
UT Southwestern Medical Center
Leif Oxburgh, DVM, PhD
Center for Molecular Medicine,
Maine Medical Centre Research Institute
How to think about
Phase One Strategic
Research Goals
Module 1
KIDNEY COORDINATORS

4. SEPT. 14 & 15, 2015 - AUSTIN, TX
Kidney Regeneration & Bioengineering
State-of-the-Science Summit

5. Laying the Foundation
Thank you for participating in the
first SOS Kidney Summit, a gathering
specifically focused on what it’s
going to take to regenerate or
bioengineer a kidney for human
transplantation.
Identify challenges we need to overcome to
advance the science.
Prepare a meeting report for stakeholders.
Form a working group focused on Phase One
Strategic Research Goals.
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6. Rapid-Learning Modules
The Summit is organized into four
Rapid-Learning Modules covering
key topics. Each module is comprised
of 15-minute presentations from
subject-matter experts and concludes
with a Q&A session.
MODULE 1
Realistic Expectations: What Clinicians
Need Right Now
MODULE 2
Repair: Is It Possible to Build Kidney Tissue
In Situ?
MODULE 3
Building Blocks: Cell Sources for Tissue
Generation
MODULE 4
Biological Structure: Issues to Consider in
Engineering De Novo Kidney Tissue

7. Repair: Is It Possible to Build Kidney Tissue In Situ?
Module 2
9:30 a.m.
Cellular Approaches Used to Enhance
Regeneration in Injured Kidneys
Lloyd G. Cantley, MD
9:15 a.m.
Lessons Learned From Zebrafish About
Regenerating Kidney Tissue
Iain A. Drummond, PhD
Q&A / Group Discussion
9:45 a.m.
9:00 - 10:30 a.m. | 1HR 30M
9:00 a.m.
How Cell Developmental Processes Can Be
Reactivated to Repair Damaged Organs
Manuel Serrano, PhD

8. Module 3
Building Blocks: Cell Sources for Tissue Generation
10:30 a.m. - Noon | 1HR 30M
Q&A / Group Discussion
11:15 a.m.
10:30 a.m.
Status of Reproducibility, Genetic State and
Immune Tolerance of iPSCs and hESCs
Samantha Morris, PhD
10:45 a.m.
Generating Cell Types Needed for De Novo
Nephrogenesis
Andrew McMahon, PhD
11:00 a.m.
Scientific and Ethical Challenges of
Xenotransplantation
David K.C. Cooper, MD, PhD, FRCS

9. Please enjoy lunch and plan to be back in your seat
by 12:55 p.m. We will resume promptly at 1 p.m.
LUNCH Noon - 1 p.m. | 1HR

10. Module 4 1:00 - 3:45 p.m. | 2HR 45M
Biological Structure: Issues to Consider in Engineering De Novo
Kidney Tissue
1:00 p.m.
Essential Angiogenesis Parameters for De
Novo Tissue Generation
Ondine Cleaver, PhD
1:15 p.m.
Key Glomerulus Features to be Included in
Engineered Kidney Tissue
Stuart Shankland, MD
1:30 p.m.
Pros and Cons of Using a Decellularized ECM
to Engineer a De Novo Kidney
Jason A. Wertheim, MD, PhD
1:45 p.m.
Pros and Cons of Using Artificial Scaffolds to
Engineer De Novo Kidney Tissue
David Kaplan, PhD
2:00 p.m.
Group Discussion
2:45 p.m.
Phase One Strategic Research Goals

11. Identify
Phase One Strategic Research Goals

12. Form the Whole Kidney Research Community Please complete the
form in your registration packet and give it to an SOS staff member.
Disseminate Meeting Report This report will define our starting line
and will be shared with a variety of stakeholders.
Secure Funding for Research Initiatives Our mission is to raise
money to fund high impact research initiatives.
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NEXT STEPS

13. Thanks to Dr. Carroll and Dr. Oxburgh for their help in
organizing and leading today’s Summit. And thank you for
your participation!
Thomas Carroll
Chief Science Coordinator, Kidney
UT Southwestern University
Leif Oxburgh
Chief Science Coordinator, Kidney
Maine Medical Center Research Institute